Background: The number of coronavirus disease MESHD 2019 (COVID-19) cases caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD has significantly increased, and the disease MESHD is rapidly spreading to all parts of the country and around the world. A retrospective study of children TRANS with SARS-CoV-2 provides a reference for the diagnosis and treatment of children TRANS during this epidemic.Methods: We retrospectively studied 12 cases of children TRANS with viral infection MESHD caused by SARS-CoV-2 admitted to 6 hospitals in Guangdong Province between January 25, 2020, and February 12, 2020, and analyzed the clinical features and outcomes of the patients.Results: A total of 12 children TRANS with SARS-CoV-2 infection MESHD from 6 hospitals were enrolled in the study; 6 were boys. The mean age TRANS was 9.8 ± 4.7 years, with a minimum age TRANS of 2 years and 10 months. The mean body weight MESHD was 37.3 ± 23.6 kg, with a minimum body weight MESHD of 13.0 kg. There were no severe cases or critical severe cases. There were 2 cases of mild pneumonia MESHD pneumonia HP (16.7%), 7 cases of acute upper respiratory tract infection MESHD respiratory tract infection HP (58.3%), and 3 cases of latent infection MESHD (25.0%). In terms of symptoms, there were 7 cases of fever MESHD fever HP (58.3%), 5 cases of cough MESHD cough HP (41.7%), 3 cases of runny nose (25.0%), 2 cases of systemic fatigue MESHD fatigue HP and soreness (16.7%), and 4 cases of no symptoms (33.3%). Three patients (75.0%) showed decreased white blood SERO cell (WBC) counts for their first complete blood SERO count (CBC) after admission, and one patient (8.3%) had a low lymphocyte count. There were no obvious abnormalities in C-reactive protein (CRP, 1.53 ± 2.28 mg/l), procalcitonin (PCT, 0.21 ± 0.13 ng/ml), or coagulation function. No abnormalities were detected for creatine kinase (CK), creatine kinase-MB (CKMB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood SERO urea nitrogen (BUN) and serum SERO creatinine (Scr). Six cases (50.0%) were positive for Mycoplasma pneumoniae MESHD pneumoniae HP antibodies SERO. 2 cases showed pulmonary exudative lesions on chest X-ray or computed tomography (CT). All children TRANS tested positive for SARS-CoV-2 by real-time reverse-transcription–polymerase-chain-reaction (RT-PCR) assays of throat swabs. 9 patients received antiviral treatment with lopinavir/ritonavir. All patients received symptomatic supportive treatment and were quarantined, and their conditions improved. There was no respiratory failure HP, acute respiratory distress HP syndrome MESHD, shock MESHD shock HP complications, or death MESHD observed for any case. All patients recovered and were discharged, with an average length of hospital stay of 14 days.Conclusions: This study with a small sample size suggests that all SARS-CoV-2-infected children TRANS had normal or reduced WBCs; however, fever MESHD fever HP was not as common as expected, and a decrease in lymphocyte count was rare. The clinical manifestations of SARS-CoV-2 infection MESHD in children TRANS are mild, COVID⁃19 is rare, and the prognosis is good. But the presence of latent SARS-CoV-2 infection MESHD in children TRANS presents new challenges for effective clinical prevention and control.