Corpus overview


Overview

MeSH Disease

Human Phenotype

Bronchiectasis (6)

Pneumonia (4)

Cough (4)

Fever (3)

Falls (1)


Transmission

Seroprevalence
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    A nomogram for predicting the severity of COVID-19 using laboratory examination and CT findings

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Jian Wang; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-46841/v1 Date: 2020-07-21 Source: ResearchSquare

    Background: The outbreak of COVID-19 has a significant impact on the health of people around the world. In the clinical condition of COVID-19, the condition of critical cases changes rapidly with a high mortality rate. Therefore, early prediction of disease MESHD severity and active intervention play an important role in the prognosis of severe patients.Methods: All the patients with COVID-19 in Taizhou city were retrospectively included and segregated into the non-severe and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examination results, and imaging findings of the 2 groups were analysed for comparing the differences between the 2 groups. Univariate and multivariate logistic regression were used for screening the factors that could predict the disease MESHD, and the nomogram was constructed.Results: A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 years (range, 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. By using the method of multivariate logistic regression, the variables to construct nomogram include age TRANS (OR: 1.052, 95% CI: 1.020–1.086, P = 0.001), body temperature (OR: 2.252, 95% CI: 1.139–4.450, P = 0.020), lymphocyte count (OR: 1.128, 95% CI: 1.000–1.272, P = 0.049), ADA (OR: 1.163, 95% CI: 1.023–1.323, P = 0.021), PaO2 (OR: 0.972, 95% CI: 0.953–0.992, P = 0.007), IL-10 (OR: 1.184, 95% CI: 1.037–1.351, P = 0.012), and bronchiectasis MESHD bronchiectasis HP (OR: 3.818, 95% CI: 1.694–8.605, P = 0.001). The AUC of the established nomogram was 0.877.Conclusions: This study established a stable nomogram for predicting the severity of COVID-19, and the clinicians can use the established nomogram for predicting the severity of newly diagnosed COVID-19 patients and to conduct active intervention for minimising the mortality rate and improving the prognosis of severe patients.

    Impact of the COVID-19 epidemic on outpatient visits of common respiratory diseases MESHD

    Authors: Weiyi Wang; Yulu Zheng; Libin Jiang

    doi:10.21203/rs.3.rs-34656/v1 Date: 2020-06-11 Source: ResearchSquare

    Background/Purpose The outbreak of corona virus disease MESHD 2019 (COVID-19) has become a worldwide threat to public health. The purpose of this study is to analyze the impact of COVID-19 epidemic on outpatient visits of common respiratory diseases MESHD. Methods Through statistics and comparing the data with the same period last year,we present the changes of outpatient visits of 14 common respiratory diseases MESHD in an upper first-class hospital in China from January to May,2020. Results From January to May,2020, the number of outpatient visits of most common respiratory diseases MESHD fell HP below the previous year,and total number of outpatient visits of 14 common respiratory diseases MESHD decreased by 58.07% year-on-year. Bronchitis MESHD Bronchitis HP, pneumonia MESHD pneumonia HP, cough MESHD cough HP, acute upper respiratory infection MESHD and bronchiectasis MESHD bronchiectasis HP infection MESHD are in our top 5 drop list,decreased by 76.79%,71.03%,66.51%56.87% and 56.31% respectively. Conclusion COVID-19 epidemic had a strong influence on the outpatient visits of common respiratory diseases MESHD, particularly for infectious diseases MESHD.

    CT features of COVID-19 patients with two consecutive negative RT-PCR tests after treatment

    Authors: Zhao Fu; Ningning Tang; Yanqing Chen; Longbai Ma; Youyong Wei; Yumin Lu; Kun Ye; Hang Liu; Fen Tang; Guangyi Huang; Yingxia Yang; Fan Xu

    doi:10.21203/rs.3.rs-33163/v1 Date: 2020-06-02 Source: ResearchSquare

    Purpose: The objective of this study is to expound the CT features of COVID-19 patients whose nucleic acid tests converted to negative after treatment.Materials and Methods: We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. The cases were divided into moderate group and severe/critical group according to disease MESHD severity. Clinical and CT scanning data were collected. CT signs of pulmonary lesions and the score of long involvement were expounded.Results: 39 moderate cases and 7 severe/critical cases were included. All moderate patients showed peripheral lesions while severe/critical cases exhibited both central and peripheral lesions with all lobes involvement. Ground glass opacity (GGO) and mixed GGO were observed. Aberrant pulmonary interstitium manifested as reticular and thin linear pattern. Thickened blood SERO vessels and pleural thickening HP were found. Pulmonary fibrosis MESHD Pulmonary fibrosis HP, annular thickening of the bronchial wall, bronchiectasis MESHD bronchiectasis HP, air bronchogram and small amount of bilateral pleural effusion MESHD pleural effusion HP were observed in severe/critical patients. The severe/critical group showed higher CT score of involvement.Conclusions: Pulmonary lesions persisted even after twice consecutive nucleic acid tests converted to negative. We strongly recommended regular follow-up of CT scans after nucleic acid tests conversion. Evaluation of complete remission should base on chest CT.

    Clinical Characteristics and CT Manifestations of 143 Patients With 2019 Novel Coronavirus Disease MESHD (COVID-19) in Taizhou City, Zhejiang, China

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Shuying Ying; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-32895/v1 Date: 2020-06-01 Source: ResearchSquare

    Background: In December 2019, the first case of pneumonia MESHD pneumonia HP associated with the SARS-CoV-2 was found in Wuhan and rapidly spread throughout China, so data are needed on the affected patients. The purpose of our study was to find the clinical manifestations and CT features of COVID-19.Methods: All patients with COVID-19 in Taizhou city were retrospectively included and divided into non-severe group and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examinations and imaging features of COVID-19 patients were analyzed, and the differences between the two groups were compared.Results: A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 (range 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. Between two groups of cases, the results of aspartate transaminase, creatine kinase and lactate dehydrogenase, serum SERO albumin, CR, glomerular filtration rate, amyloid protein A, fibrinogen, calcitonin level and oxygen partial pressure, IL – 10, absolute value of CD3, CD4, CD8 were different, and the difference was statistically significant (P < 0.05). Therefore, these quantitative indicators can be used to help assess the severity. On admission, the CT showed that the lesions were mostly distributed in the periphery of the lung or subpleural (135 cases (98%)), and most of lesions presented as patchy (81%), mixed density (63%) shadow. Consolidation (68% vs 41%), bronchial inflation signs (59% vs 41%), and bronchiectasis MESHD bronchiectasis HP (71% vs 39%) were more common in the severe group.Conclusions: Most of the cases of COVID-19 in Taizhou have mild symptoms and no death MESHD. In addition to clinical symptoms, some laboratory tests (such as absolute values of CD4 and CD8) and CT findings can be used to assess the severity of the disease MESHD.

    Early fibroproliferative changes on high-resolution CT predict mortality in COVID-19 pneumonia MESHD pneumonia HP patients with ARDS

    Authors: Zhilin Zeng; Min Xiang; Hanxiong Guan; Yiwen liu; huilan Zhang; Liming Xia; Zhan Juan; Qiongjie Hu

    doi:10.21203/rs.3.rs-32245/v1 Date: 2020-05-28 Source: ResearchSquare

    Objectives: To investigate the chest high-resolution CT (HRCT) findings in coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP patients with acute respiratory distress HP syndrome MESHD (ARDS) and to evaluate its relationship with clinical outcome.Materials and Methods In this retrospective study, seventy-nine COVID-19 patients with ARDS were recruited. Clinical data were extracted from electronic medical records and analyzed. HRCT scans, obtained within 3 days before clinical ARDS onset, were evaluated by three independent observers and graded into six findings according to the extent of fibroproliferation. Multivariable Cox proportional hazard regression analysis was used to assess the independent predictive value of the CT score and radiologically fibroproliferation. Patient survival was determined by Kaplan-Meier analysis.Results: Compared with survivors, non-survivors showed higher of lung fibroproliferation, whereas there no significant differences in the area of increased attenuation without traction bronchiolectasis HP or bronchiectasis MESHD bronchiectasis HP. A HRCT score <230 enabled prediction of survival with 73.5% sensitivity SERO and 93.3% specificity (AUC= 0.9; 95% CI 0.831 to 0.968). Multivariate Cox proportional hazards model showed that the HRCT score is a significant independent risk factor for mortality (HR 13.007; 95% CI 3.935 to 43.001). Kaplan-Meier analysis revealed HRCT score≥230 was associated with higher fatality rate. Organ injury occurred less frequently in patients with HRCT score<230 compared to those with HRCT score≥230.Conclusion: Early pulmonary fibroproliferative changes in HRCT predicts increased mortality and susceptibility to organ injury in COVID-19 pneumonia MESHD pneumonia HP patients with early ARDS.

    Clinical Characteristics and CT Manifestations of 143 Patients With 2019 Novel Coronavirus Disease MESHD (COVID-19) in Taizhou City, Zhejiang, China

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Shuying Ying; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-23614/v1 Date: 2020-04-17 Source: ResearchSquare

    Background In December 2019, the first case of pneumonia MESHD pneumonia HP associated with the SARS-CoV-2 was found in Wuhan and rapidly spread throughout China, so data are needed on the affected patients. The purpose of our study was to find the clinical manifestations and CT features of COVID-19.Methods All patients with COVID-19 in Taizhou city were retrospectively included and divided into non-severe group and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examinations and imaging features of COVID-19 patients were analyzed, and the differences between the two groups were compared.Results A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 (range 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. Between two groups of cases, the results of aspartate transaminase, creatine kinase and lactate dehydrogenase, serum SERO albumin, CPR, glomerular filtration rate, amyloid protein A, fibrinogen, calcitonin level and oxygen partial pressure, red protein, IL – 10, absolute value of CD3, CD4, CD8 were different, and the difference was statistically significant (P < 0.05). On admission, the CT showed that the lesions were mostly distributed in the external lung or under the pleura (135 cases (98%)), and most of lesions presented as patchy (81%), heterogeneous (73%) and mixed density (63%) shadow. Consolidation (68% vs 41%), bronchial inflation signs (59% vs 41%), and bronchiectasis MESHD bronchiectasis HP (71% vs 39%) were more common in the severe group.Conclusions Most of the cases of COVID-19 in Taizhou have mild symptoms and no death MESHD. In addition to clinical symptoms, some laboratory tests (such as absolute values of CD4 and CD8) and CT findings can be used to assess the severity of the disease MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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