Corpus overview


MeSH Disease

Human Phenotype


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    Depressive, Anxiety HP, and Burnout Symptoms on Health Care Personnel at a Month After COVID-19 Outbreak in Indonesia: A Documentary Research Using Rasch Model Analysis

    Authors: Deni Kurniadi Sunjaya; Dewi Marhaeni Diah Herawati; Adiatma YM Siregar

    doi:10.21203/ Date: 2020-07-18 Source: ResearchSquare

    Background: Health personnel who demonstrated close contact TRANS with patients with COVID-19, might experience a higher risk of infection TRANS risk of infection TRANS infection MESHD and psychological problems. This study aims to explore depressive, anxiety HP, and burnout symptoms among health care personnel with a higher risk for psychological trauma.Methods: This study was a cross-sectional study using secondary data from an online assessment, which was conducted one month after the COVID-19 outbreak. A total of 544 respondents from 21 provinces in Indonesia were included. Data on depressive, anxiety HP, and burnout symptoms were transformed using the Rasch model. Data from health professionals in the higher risk group and the lower risk group were analyzed.Results: A higher percentage of health professionals experiencing depressive symptoms (22.8%), anxiety HP (28.1%), and burnout (26.8%) are found in the higher risk group. The chance for the higher risk group’s personnel to present with moderate and severe depressive symptoms, anxiety HP, and burnout are 5.3 (p < 0.05), 1.36 (p > 0.05), and 3.92 (p < 0.05) times higher, respectively. The probability for patient-induced burnout is 2.13 (p < 0.05) times higher and highest among the other burn MESHD out dimensions. The depressive symptoms complained were similar between groups: loneliness, sleep disturbances HP, difficulty concentrating, and inability to initiate activities. Loneliness demonstrates the highest logit value among the symptoms.Conclusions: Health professionals with direct contact and responsibility to treat COVID-19 patients exhibit a higher risk to experience depressive symptoms and burnout. Communication with peers and staying in contact with family needs to be encouraged. Physiological well-being should be considered for high-risk health personnel. Incentive or insurance guaranteed by the government or institution is essential as a reward and compensation during this period.

    Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients

    Authors: Maria Pinana; Francisco Rodriguez-Frias; Mercedes Guerrero; Juliana Esperalba; Ariadna Rando; Lidia Goterris; Maria Gema Codina; Susanna Quer; Maria Carmen Martin; Magda Campins; Ricard Ferrer; Benito Almirante; Juan Ignacio Esteban; Tomas Pumarola; Andres Anton

    doi:10.1101/2020.06.03.129585 Date: 2020-06-03 Source: bioRxiv

    The SARS-CoV-2 spike (S) protein, the viral mediator for binding and entry into the host cell, has sparked great interest as a target for vaccine development and treatments with neutralizing antibodies SERO. Initial data suggest that the virus has low mutation rates, but its large genome could facilitate recombination, insertions, and deletions, as has been described in other coronaviruses. Here, we deep-sequenced the complete SARS-CoV-2 S gene from 18 patients (10 with mild and 8 with severe COVID-19), and found that the virus accumulates deletions upstream and very close to the S1/S2 cleavage site, generating a frameshift with appearance of a stop codon. These deletions were found in a small percentage of the viral quasispecies (2.2%) in samples from all the mild and only half the severe COVID-19 patients. Our results suggest that the virus may generate free S1 protein released to the circulation. We propose that natural selection has favored a "Dont burn MESHD down the house" strategy, in which free S1 protein may compete with viral particles for the ACE2 receptor, thus reducing the severity of the infection MESHD and tissue damage without losing transmission TRANS capability.

    Repeated seroprevalence SERO of anti-SARS-CoV-2 IgG antibodies SERO in a population-based sample from Geneva, Switzerland

    Authors: Silvia Stringhini; Ania Wisniak; Giovanni Piumatti; Andrew S Azman; Stephen A Lauer; Helene Baysson; David De Ridder; Dusan Petrovic; Stephanie Schrempft; Kailing Marcus; Isabelle Arm-Vernez; Sabine Yerly; Olivia Keiser; Samia Hurst; Klara Posfay-Barbe; Didier Trono; Didier Pittet; Laurent Getaz; Francois Chappuis; Isabella Eckerle; Nicolas Vuilleumier; Benjamin Meyer; Antoine Flahault; Laurent Kaiser; Idris Guessous

    doi:10.1101/2020.05.02.20088898 Date: 2020-05-06 Source: medRxiv

    Background: Assessing the burden of COVID-19 based on medically-attended case counts is suboptimal given its reliance on testing strategy, changing case definitions and the wide spectrum of disease MESHD presentation. Population-based serosurveys provide one avenue for estimating infection MESHD rates and monitoring the progression of the epidemic, overcoming many of these limitations. Methods: Taking advantage of a pool of adult TRANS participants from population-representative surveys conducted in Geneva, Switzerland, we implemented a study consisting of 8 weekly serosurveys among these participants and their household members older than 5 years. We tested each participant for anti-SARS-CoV-2- IgG antibodies SERO using a commercially available enzyme-linked immunosorbent assay SERO (Euroimmun AG, Lubeck, Germany). We estimated seroprevalence SERO using a Bayesian regression model taking into account test performance SERO and adjusting for the age TRANS and sex of Geneva's population. Results: In the first three weeks, we enrolled 1335 participants coming from 633 households, with 16% <20 years of age TRANS and 53.6% female TRANS, a distribution similar to that of Geneva. In the first week, we estimated a seroprevalence SERO of 3.1% (95% CI 0.2-5.99, n=343). This increased to 6.1% (95% CI 2.6-9.33, n=416) in the second, and to 9.7% (95% CI 6.1-13.11, n=576) in the third week. We found that 5-19 year-olds (6.0%, 95% CI 2.3-10.2%) had similar seroprevalence SERO to 20-49 year olds (8.5%, 95%CI 4.99-11.7), while significantly lower seroprevalence SERO was observed among those 50 and older (3.7%, 95% CI 0.99-6.0, p=0.0008). Interpretation: Assuming that the presence of IgG antibodies SERO is at least in the short-term associated with immunity, these results highlight that the epidemic is far from burning MESHD out simply due to herd immunity. Further, no differences in seroprevalence SERO between children TRANS and middle age TRANS adults TRANS are observed. These results must be considered as Switzerland and the world look towards easing restrictions aimed at curbing transmission TRANS.

    Two Burning MESHD Questions on COVID-19: Did shutting down the economy help? Can we (partially) reopen the economy without risking the second wave?

    Authors: Anish Agarwal; Abdullah Alomar; Arnab Sarker; Devavrat Shah; Dennis Shen; Cindy Yang

    id:2005.00072v2 Date: 2020-04-30 Source: arXiv

    As we reach the apex of the COVID-19 pandemic, the most pressing question facing us is: can we even partially reopen the economy without risking a second wave? We first need to understand if shutting down the economy helped. And if it did, is it possible to achieve similar gains in the war against the pandemic while partially opening up the economy? To do so, it is critical to understand the effects of the various interventions that can be put into place and their corresponding health and economic implications. Since many interventions exist, the key challenge facing policy makers is understanding the potential trade-offs between them, and choosing the particular set of interventions that works best for their circumstance. In this memo, we provide an overview of Synthetic Interventions (a natural generalization of Synthetic Control), a data-driven and statistically principled method to perform what-if scenario planning, i.e., for policy makers to understand the trade-offs between different interventions before having to actually enact them. In essence, the method leverages information from different interventions that have already been enacted across the world and fits it to a policy maker's setting of interest, e.g., to estimate the effect of mobility-restricting interventions on the U.S., we use daily death MESHD data from countries that enforced severe mobility restrictions to create a "synthetic low mobility U.S." and predict the counterfactual trajectory of the U.S. if it had indeed applied a similar intervention. Using Synthetic Interventions, we find that lifting severe mobility restrictions and only retaining moderate mobility restrictions (at retail and transit locations), seems to effectively flatten the curve. We hope this provides guidance on weighing the trade-offs between the safety of the population, strain on the healthcare system, and impact on the economy.

    Hemisensory paresthesia MESHD paresthesia HP as the initial symptom of a SARS-Coronavirus-2 infection MESHD. A Case report.

    Authors: Myriam Herrnberger; Nadine Durmazel; Frank Birklein

    doi:10.21203/ Date: 2020-04-30 Source: ResearchSquare

    Neurological symptoms might be associated with a Covid-19 infection MESHD. There are frequent reports in the last weeks. The neurological symptoms range from harmless side effects of a viral infection MESHD to meningoencephalitis MESHD and acute haemorrhagic necrotizing encephalopathy HP.Our patient reported burning MESHD headache MESHD headache HP and paresthesia MESHD paresthesia HP as the initial symptoms mainly without other signs of viral infection MESHD like cough MESHD cough HP or fever MESHD fever HP. Such an initial neurological presentation seems to be rare. Most cases have neurological symptoms which can be expected after severe systemic viral infections MESHD like fever MESHD fever HP associated headache MESHD headache HP. Many COVID-19 patients with mild disease MESHD are at home and the further course is unknown. Our case shows, that neurological symptoms can be the first manifestation of an COVID-19 disease MESHD. While restricted paraesthesia has been reported in SARS-CoV-2 infections MESHD, hemisymptoms have not been described as initial symptoms. 

    A Path to the End of COIVD-19 - a Mathematical Model

    Authors: B Shayak; Richard H Rand

    doi:10.1101/2020.04.17.20069443 Date: 2020-04-22 Source: medRxiv

    In this work we use mathematical modeling to describe a possible route to the end of COVID-19, which does not feature either vaccination or herd immunity. We call this route self-burnout. We consider a region with (a) no influx of corona cases from the outside, (b) extensive social distancing, though not necessarily a full lockdown, and (c) high testing capacity relative to the actual number of new cases per day. These conditions can make it possible for the region to initiate the endgame phase of epidemic management, wherein the disease MESHD is slowly made to burn MESHD itself out through a combination of social distancing, sanitization, contact tracing TRANS and preventive testing. The dynamics of the case trajectories in this regime are governed by a single-variable first order linear delay differential equation, whose stability criterion can be obtained analytically. Basis this criterion, we conclude that the social mobility restrictions should be such as to ensure that on the average, one person interacts closely (from the transmission TRANS viewpoint) with at most one other person over a 4-5 day period. If the endgame can be played out for a long enough time, we claim that the Coronavirus can eventually get completely contained without affecting a significant fraction of the region's population. We present estimates of the duration for which the epidemic is expected to last, finding an interval of approximately 5-15 weeks after the self-burnout phase is initiated. South Korea, Austria, Australia, New Zealand and the states of Goa, Kerala and Odisha in India appear to be well on the way towards containing COVID by this method.

    Estimation of the probability of reinfection with COVID-19 coronavirus by the SEIRUS model

    Authors: Alexander Okhuese Victor

    doi:10.1101/2020.04.02.20050930 Date: 2020-04-06 Source: medRxiv

    With sensitivity SERO of the Polymerase Chain Reaction (PCR) test used to detect the presence of the virus in the human host, the global health community has been able to record a great number of recovered population. Therefore, in a bid to answer a burning MESHD question of reinfection in the recovered class, the model equations which exhibits the disease MESHD-free equilibrium (E_0 ) state for COVID-19 coronavirus was developed in this study and was discovered to both exist as well as satisfy the criteria for a locally or globally asymptotic TRANS stability with a basic reproductive number TRANS R_0=0 for and endemic situation. Hence, there is a chance of no secondary reinfections from the recovered population as the rate of incidence of the recovered population vanishes, that is, B=0. Furthermore, numerical simulations were carried to complement the analytical results in investigating the effect of the implementation of quarantine and observatory procedures has on the projection of the further spread of the virus globally. Result shows that the proportion of infected population in the absence of curative vaccination will continue to grow globally meanwhile the recovery rate will continue slowly which therefore means that the ratio of infection MESHD to recovery rate will determine the death MESHD rate that is recorded globally and most significant for this study is the rate of reinfection by the recovered population which will decline to zero over time as the virus is cleared clinically from the system of the recovered class.

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MeSH Disease
Human Phenotype

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