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    The influence of pH on SARS-CoV-2 infection MESHD and COVID-19 severity

    Authors: Leandro Jimenez; Ana C Codo; Vanderson S Sampaio; Antonio E.R. Oliveira; Lucas KK Ferreira; Gustavo G Davanzo; Lauar B Monteiro; Joao V Virgilio-da-Silva; Mayla GS Borba; Gabriela F Souza; Nathalia Zini; Flora A Gandolfi; Stefanie P Murano; Jose L Proenca-Modena; Fernando A Val; Gisely C Melo; Wuelton M Monteiro; Mauricio L Nogueira; Marcus VG Lacerda; Pedro M Moraes-Vieira; Helder I Nakaya; Qiao Wang; Hongbin Ji; Youhua Xie; Yihua Sun; Lu Lu; Yunjiao Zhou

    doi:10.1101/2020.09.10.20179135 Date: 2020-09-11 Source: medRxiv

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect MESHD a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia MESHD may also increase the expression of ACE2. Here we showed that patients with Barrett's esophagus MESHD ( BE MESHD) have a higher expression of ACE2 in BE MESHD tissues compared to normal squamous esophagus MESHD, and that the lower pH associated with BE MESHD may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased ACE2 expression and viral load upon SARS-CoV-2 infection MESHD. We also showed in two independent cohorts of COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death MESHD compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection MESHD and COVID-19 severity.

    Pulmonary alveolar MESHD regrowth in an adult TRANS COVID-19 patient

    Authors: Jingyu Chen; Huijuan Wu; Yuanyuan Yu; Nan Tang

    doi:10.1101/2020.05.10.20097634 Date: 2020-06-01 Source: medRxiv

    We detected active alveolar MESHD regrowth in the lung of a 58-year-old COVID-19 patient who underwent lung transplantation due to severe lung hemorrhage MESHD. Specifically, immunohistological and scanning electronic microscopy analyses revealed that alveolar type II epithelial MESHD cells (AT2 cells) accumulate in response to viral pneumonia HP pneumonia MESHD and that these AT2 cells actively proliferate and differentiate into squamous MESHD AT1-like alveolar MESHD epithelial cells. Thus, our work establishes that alveolar MESHD regrowth does occur in post-COVID-19 injury adult TRANS human lungs.

    Analysis the susceptibility of lung cancer MESHD patients to SARS-CoV-2 infection MESHD

    Authors: Qi Kong

    doi:10.21203/rs.3.rs-17713/v1 Date: 2020-03-17 Source: ResearchSquare

    Recent studies have reported that 2019 novel coronavirus disease MESHD (COVID-19) patients with lung cancer MESHD have a higher risk of severe events than patients without cancer MESHD. In this study, we investigated the expression of severe acute respiratory syndrome coronavirus 2 MESHD ( SAR TRANS-CoV-2) receptor angiotensin I-converting enzyme 2 (ACE2) and the cellular protease transmembrane serine protease 2 (TMPRSS2) and their associations with prognosis in lung adenocarcinoma HP (LUAD) and lung squamous cell carcinoma HP lung squamous cell carcinoma MESHD ( LUSC MESHD). We found that there are significant differences in susceptibility to SAR TRANS-CoV-2 among each age TRANS stages of individuals with the expression of ACE2. ACE2 was also high expressed in LUAD and LUSC MESHD, and this suggests that COVID-19 patients with lung cancers MESHD are susceptible to SAR TRANS SAR MESHD-CoV-2 infection. Our data showed the differential gene expression level and gene coexpression of ACE2 and TMPRSS2 among each subtypes and pathological stages of LUAD and LUSC MESHD and the data were verified by meta-analysis, gene expression omnibus (GEO) data and animal models results. 

    Clinical Pathology of Critical Patient with Novel Coronavirus Pneumonia HP (COVID-19)

    Authors: Weiren Luo; Hong Yu; Jizhou Gou; Xiaoxing Li; Yan Sun; Jinxiu Li; Lei Liu

    id:202002.0407/v4 Date: 2020-03-09 Source: Preprints.org

    Background Critical patients with novel coronavirus pneumonia MESHD pneumonia HP ( COVID-19) have worse outcome and high mortality. However, the histopathology of critical patient with COVID-19 remains undisclosed. Methods We performed the whole lung biopsy, and described the pathological changes of critical COVID-19 patient done with transplant by HE staining, immunohistochemistry and special staining observed under the microscopy. Findings The whole lungs displayed diffuse congestive appearance and partly haemorrhagic necrosis MESHD on gross examination. The haemorrhagic necrosis MESHD was prominently present in outer edge of the right lower lung. The cut surfaces of the lung displayed severe congestive and haemorrhagic changes. The main pathological changes showed massive pulmonary interstitial fibrosis MESHD, and partly hyaline degeneration MESHD, variable degrees of hemorrhagic pulmonary infarction MESHD. Small vessels hyperplasia MESHD, vessel wall thickening, lumen stenosis, occlusion and microthrombosis MESHD formation. Focal monocytes, lymphocytes and plasma SERO cells infiltrating into pulmonary HP interstitium. Bronchiolitis HP Bronchiolitis MESHD and alveolitis with proliferation, atrophy MESHD, desquamation MESHD and squamous MESHD metaplasia of epithelial cells. Atrophy MESHD, vacuolar degeneration, proliferation, desquamation MESHD and squamous MESHD metaplasia in alveolar epithelial MESHD cells. Alveolar MESHD cavity congestion was prominent, and contained mucus, edema HP edema MESHD fluid, desquamated epithelial cells, and inflammatory cells. We also found several multinucleate giant cells and intracytoplasmic viral inclusion bodies. Special stains including Masson stain, sirius red staining, reticular fibers staining indicated massive pulmonary interstitial fibrosis MESHD. Immunohistochemistry showed positive for immunity cells including CD3, CD4, CD8, CD20, CD79a, CD5, CD38 and CD68. Interpretation We demonstrate the pathological findings of critical patient with COVID-19, which might provide a deep insight of the pathogenesis and severity of this disease.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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