Corpus overview


Overview

MeSH Disease

Human Phenotype

Delirium (1)

Stroke (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Clinical features and outcomes of inpatients with neurological disease MESHD and COVID-19

    Authors: Alberto Benussi; Andrea Pilotto; Enrico Premi; Ilenia Libri; Marcello Giunta; Chiara Agosti; Antonella Alberici; Enrico Baldelli; Matteo Benini; Sonia Bonacina; Laura Brambilla; Salvatore Caratozzolo; Matteo Cortinovis; Angelo Costa; Stefano Cotti Piccinelli; Elisabetta Cottini; Viviana Cristillo; Ilenia Delrio; Massimiliano Filosto; Massimo Gamba; Stefano Gazzina; Nicola Gilberti; Stefano Gipponi; Alberto Imarisio; Paolo Invernizzi; Ugo Leggio; Matilde Leonardi; Paolo Liberini; Martina Locatelli; Stefano Masciocchi; Loris Poli; Renata Rao; Barbara Risi; Luca Rozzini; Andrea Scalvini; Francesca Schiano di Cola; Raffaella Spezi; Veronica Vergani; Irene Volonghi; Nicola Zoppi; Barbara Borroni; Mauro Magoni; Alessandro Pezzini; Alessandro Padovani

    doi:10.1101/2020.04.28.20082735 Date: 2020-05-02 Source: medRxiv

    Objective: To report the clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurological diseases MESHD with and without COVID-19. Methods: In this retrospective, single center cohort study, we included all adult TRANS inpatients with confirmed COVID-19, admitted to a Neuro-COVID Unit from February 21, 2020, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records and compared (FDR-corrected) to those of neurological patients without COVID-19 admitted in the same period. Results: 173 patients were included in this study, of whom 56 were positive for COVID-19 while 117 were negative for COVID-19. Patients with COVID-19 were older, had a different distribution regarding admission diagnoses, including cerebrovascular disorders MESHD, and had a higher quick Sequential Organ Failure Assessment (qSOFA) score on admission (all p<0.05). In-hospital mortality rates and incident delirium MESHD delirium HP were significantly higher in the COVID-19 group (all p<0.005). COVID-19 and non-COVID patients with stroke MESHD stroke HP had similar baseline characteristics but patients with COVID-19 had higher modified Rankin scale scores at discharge, with a significantly lower number of patients with a good outcome (all p<0.001). In patients with COVID-19, multivariable regressions showed increasing odds of in-hospital death MESHD associated with higher qSOFA scores (odds ratio 4.47, 95% CI 1.21-16.5; p=0.025), lower platelet count (0.98, 0.97-0.99; p=0.005) and higher lactate dehydrogenase (1.01, 1.00-1.03; p=0.009) on admission. Conclusions: COVID-19 patients admitted with neurological disease MESHD, including stroke MESHD stroke HP, have a significantly higher in-hospital mortality, incident delirium MESHD delirium HP and higher disability than patients without COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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