Corpus overview


Overview

MeSH Disease

Chest Pain (7)

Cough (6)

Fatigue (6)

Fever (5)

Infections (5)


Human Phenotype

Chest pain (7)

Cough (6)

Fatigue (6)

Fever (5)

Myalgia (3)


Transmission

Seroprevalence
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    SARS-CoV-2 Serology Results in the First COVID-19 Case in California: A Case Report and Recommendations for Serology Testing and Interpretation

    Authors: Richard B. Lanman, MD; Todd H. Lanman

    doi:10.21203/rs.3.rs-35358/v1 Date: 2020-06-12 Source: ResearchSquare

    Background: As countries in COVID-19 pandemic lockdown begin relaxation of shelter-in-place mitigation strategies, the role of serology testing escalates in importance. However, there are no clear guidelines as to when to use qualitative rapid diagnostic serology tests (RDTs) vs. SARS-CoV-2 viral RNA load (PCR) tests as an aid in acute diagnosis of patients presenting with flu-like symptoms, nor how to interpret serology test results in asymptomatic TRANS individuals or those with atypical COVID-19 symptomatology. Here we describe, in the context of the likely first case of COVID-19 in California, with an atypical presentation and not tested acutely, who nearly 3 months later was found to be IgM- and IgG+ positive for SARS-CoV-2 antibodies SERO, highlighting the role of RDT- based serology testing SERO and interpretation in retrospective diagnosis.Case Presentation: A 62-year-old male TRANS practicing neurosurgeon had onset of flu-like symptoms on January 20 with fatigue MESHD fatigue HP, slight cough MESHD cough HP only on deep inspiration, intermittent pleuritic chest pain MESHD chest pain HP unrelated to exertion, dyspnea MESHD dyspnea HP, and night sweats HP but without fever MESHD fever HP, sore throat or rhinorrhea HP. He had recently traveled TRANS abroad but not to China. CT scan revealed right lower lobe infiltrate and effusion. Because of atypical symptoms, and low prevalence SERO of COVID-19 in January, community acquired pneumonia MESHD pneumonia HP was diagnosed and one week of doxycycline was prescribed without relief, followed by a second week of azithromycin with symptom remission. Three months later the physician-patient (author THL), tested positive for SARS-CoV-2 antibodies SERO by a serology point-of-care rapid diagnostic test (RDT).Conclusions: Serology testing may be an aid in acute diagnosis of COVID-19, especially in patients with atypical presentations, as well as in assessment of asymptomatic TRANS higher-risk persons such as healthcare workers for prior infection MESHD. Recommendations for serology testing and interpretation are explicated.

    Comparison of Clinical, Laboratory and Radiological Findings in Iranian Smokers and non- Smokers Patients with COVID-19: A Case Control Study

    Authors: Mohamad Nikpouraghdam; Ali Bahramifar; Ali Ahmadi; Dariuosh Ghasemi Vanegh Oliya; Abolfazl Jahangiri; Masour Babaei; Ali Mehdi Gholian; Seyed Reza Hosseini Zijoud; Hossein Aghamollaei

    doi:10.21203/rs.3.rs-34243/v1 Date: 2020-06-08 Source: ResearchSquare

    Objective: The current study compared the clinical, laboratory and radiological findings between groups of smokers and non- smokers Iranian patients with COVID-19. Methods: This was a case-control study done on 120 patients with COVID-19 that were admitted to Baqiyatallah hospital, Tehran, Iran during March to May 2020. Our patients were categorized into two groups: smokers (40 patients) and non-smokers (80 age TRANS and sex matched controls). Demographic and clinical characteristics, laboratory findings, imaging manifestations, and outcomes were compared between two age groups TRANS. Results: Regarding the comorbidities, no significant difference was observed between the smoker and non-smoker patients. The distribution of COVID-19 symptoms was not significantly different between smokers and non-smokers, except for chest pain MESHD chest pain HP and weakness, which were significantly more common in smokers with COVID-19. A significantly lower white blood SERO cell count and neutrophils in peripheral blood SERO sample of smokers however, no difference was found concerning lymphocyte count. Moreover, the RDW of smokers was significantly lower. Regarding the findings on CT scan of COVID-19 patients, no significant difference was found between smoker and non-smoker COVID-19 patients. One (2.5%) of deaths MESHD occurred in the smoker and 3 (3.8%) occurred in the non- smoker groups.Conclusion: Current findings showed that the clinical picture of smoker and non-smoker COVID-19 patients does not differ significantly. 

    Sociodemographic profile, clinical characteristics, anxiety HP, and depression of 74 patients infected with COVID-19: first report from Bangladesh

    Authors: Dr. Mohammad Jahid Hasan; Dr. Md. Abdullah Saeed Khan; Dr. Monjur Rahman; Dr. Md. Shahnoor Islam; Dr Sourav Debnath; Dr. Jannatul Fardous,; Professor Dr. Mohammad Robed Amin

    doi:10.21203/rs.3.rs-32517/v1 Date: 2020-05-30 Source: ResearchSquare

    Background: The pandemic of Corona Virus Disease MESHD 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence SERO of anxiety HP and depression among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age TRANS of 42.59±14.43 years with male TRANS predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever MESHD fever HP (77%), cough MESHD cough HP (58.8%), breathlessness (24.3%), myalgia MESHD myalgia HP (24.3%), sore throat (21.6%), fatigue MESHD fatigue HP (17.6%), nausea MESHD nausea and/or vomiting HP and/or vomiting MESHD (12.2%), headache MESHD headache HP (12.2%), runny nose (9.5%), chest pain MESHD chest pain HP (9.5%), diarrhea MESHD diarrhea HP (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis MESHD conjunctivitis HP (1.4%) and oral ulcer MESHD oral ulcer HP (1.4%). Overall, the prevalence SERO of anxiety HP and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety HP, 4.3% had only depression and 48.6% had both.Conclusion: Patients were mostly middle aged TRANS, male TRANS and healthy workers. Typical presentations were fever MESHD fever HP and cough MESHD cough HP. Nearly two-thirds of the patients had either or both anxiety HP and depression.

    A case report and summary of thrombocytopenia MESHD thrombocytopenia HP caused by coronavirus disease MESHD 2019

    Authors: Yibing Zhao; Na Du; Wei Li; Dongmei Xiang; Guodong Zhou; Ruixu Li; Panyang Xu; Jiancheng Xu

    doi:10.21203/rs.3.rs-20569/v1 Date: 2020-04-01 Source: ResearchSquare

    Background: Coronavirus disease MESHD 2019 has become a major problem for the world. We reported a representative case with thrombocytopenia MESHD thrombocytopenia HP.Case report: A 44-year-old female TRANS patient sought medical attention for fatigue MESHD fatigue HP and cough MESHD cough HP of 1 day duration. Thirteen days before disease MESHD onset, the patient had returned from Hubei province. Her body temperature on admission was 38.6℃. Blood SERO routine test showed a white blood SERO cell count of 4.0×109/L, lymphocyte count of 1×109/L, platelet count of 118×109/L, and C-reactive protein of 6.0mg/L. Lung computed tomography (CT) scan showed: large patches of ground-glass opacities at the posterior segment of the right upper lung lobe and bilaterally at the basal segment of the lower lung lobes. Her throat swabs tested positive for novel coronavirus nucleic acid. After antiviral and symptomatic treatment were given, on day 5 of hospitalization, her symptoms of coughing MESHD coughing HP and chest pain MESHD chest pain HP worsened after coughing MESHD coughing HP, and she also developed hemoptysis MESHD hemoptysis HP. Repeated lung CT scans showed that the lesion area had increased. The lymphocyte count had decreased to 0.55×109/L and the platelet count had decreased to 9×109/L on day 6. After a series of multimodal therapies were carried out, the patient’s platelet and lymphocyte count gradually increased to normal.Conclusion: We reported a COVID-2019 case with significant thrombocytopenia MESHD thrombocytopenia HP, which was more significantly decreased than in normal viral infections MESHD. However, the mechanism of thrombocytopenia MESHD thrombocytopenia HP is unknown and requires further research.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18696/v1 Date: 2020-03-20 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease MESHD quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis. Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020. Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever MESHD fever HP (46/64), dry cough MESHD cough HP (38/64), fatigue MESHD fatigue HP or myalgia MESHD myalgia HP (23/64), sore throat (10/64), diarrhea MESHD diarrhea HP (3/64) along with late- onset symptoms TRANS like chest pains MESHD chest pains HP (2/64) and headaches MESHD headaches HP (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia MESHD leukopenia HP. Only two patients (3.1 %) presented with leukocytosis MESHD leukocytosis HP. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death MESHD so far. Conclusions: Early intervention in COVID-19 disease MESHD improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18096/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease MESHD quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis.Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020.Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever MESHD fever HP (46/64), dry cough MESHD cough HP (38/64), fatigue MESHD fatigue HP or myalgia MESHD myalgia HP (23/64), sore throat (10/64), diarrhea MESHD diarrhea HP (3/64) along with late- onset symptoms TRANS like chest pains MESHD chest pains HP (2/64) and headaches MESHD headaches HP (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia MESHD leukopenia HP. Only two patients (3.1 %) presented with leukocytosis MESHD leukocytosis HP. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death MESHD so far. Conclusions: Early intervention in COVID-19 disease MESHD improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Analysis clinical features of COVID-19 infection MESHD in secondary epidemic area and report potential biomarkers in evaluation

    Authors: Weiping Ji; Gautam Bishnu; Xian Shen; Zhenzhai Cai

    doi:10.21203/rs.3.rs-16658/v1 Date: 2020-03-05 Source: ResearchSquare

    Objective: Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease MESHD in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.Methods: The clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease MESHD, we found that the primary symptoms were fever MESHD fever HP, cough MESHD cough HP, fatigue MESHD fatigue HP, chest tightness HP, chest pain MESHD chest pain HP and specific blood SERO test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.Results: The main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel TRANS history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs MESHD between the two groups (P>0.05). Some patients had abnormally increased serum SERO amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).Conclusion: Respiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection MESHD in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum SERO amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood SERO parameters and thus may be an effective evaluation index for patients with COVID-19 infection MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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