Respiratory disease MESHD caused by the 2019 novel coronavirus (2019-nCoV) pneumonia MESHD pneumonia HP first emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other provinces and other countries. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and has been suggested to be also the receptor for 2019-nCoV. Paradoxically, ACE2 expression in the lung protects mice from SARS-CoV spike protein induced lung injury MESHD by attenuating the renin-angiotensin system. In the intestine, ACE2 also suppresses intestinal inflammation MESHD by maintaining amino acid homeostasis, antimicrobial peptide expression and ecology of the gut microbiome. Upon analysis of single cell-RNA sequencing data from control subjects and those with colitis MESHD colitis HP or inflammatory bowel disease MESHD (IBD), we found that ACE2 expression in the colonocytes was positively associated with genes regulating viral infection MESHD, innate and cellular immunity, but was negatively associated with viral transcription, protein translation, humoral immunity, phagocytosis and complement activation. In summary, we suggest that ACE2 may play dual roles in mediating the susceptibility and immunity of 2019-nCoV infection MESHD.