Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Clinical Features and Histopathological Changes of Skeletal Muscle in Patients with COVID-19: Two Case reports

    Authors: Mei-Yan Liao; Ping Duan; Zhen-Yu Pan; Yu-Xiang Cai; Wei Fan; An-Song Ping

    doi:10.21203/rs.3.rs-45595/v1 Date: 2020-07-19 Source: ResearchSquare

    BackgroundTo the best of our knowledge, muscle soreness MESHD is a common manifestation for the coronavirus disease-19 (COVID-19) patients, but the mechanism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) injury MESHD to skeletal muscle remains unclear, there has been no publication focused on muscle involvement in COVID-19 patients.Case presentationWe present the case of two Chinese men with COVID-19, whose common symptoms were fatigue HP fatigue MESHD and muscle soreness. They went through different treatments, patient 1, 81-year-old, eventually died of multi-organ failure MESHD, and patient 2, 53-year-old, underwent amputation of the mid-lower section of left thigh. Laboratory tests in both patients showed abnormal biochemical parameters associated with skeletal muscle injury MESHD. We obtained skeletal muscle samples from these two patients, one from postmortem biopsy of gastrocnemius muscle and the other from a resected left lower limb due to thrombosis MESHD. The pathological findings in patient 1 were mainly scattered atrophic muscles MESHD muscles, while fiber necrosis HP necrosis MESHD and minor inflammation MESHD were identified in patient 2, and the mild infiltrations were confirmed by CD68 and LCA staining to be predominantly macrophages and lymphocytes.ConclusionsWe report the clinical and laboratory features together with histopathological findings in skeletal muscle tissues from two COVID-19 cases and speculate that the SARS-CoV-2 may cause skeletal muscle injury MESHD. Due to the particularity of individual differences in case reports, the background of chronic neuromuscular disease MESHD in patient 1 and a minimal compartment syndrome MESHD caused by thrombosis MESHD in patient 2 need to be excluded prior to the conclusion that the skeletal muscles have been involved in COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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