Corpus overview


MeSH Disease

Human Phenotype


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    Fighting COVID-19 spread among nursing home residents even in absence of molecular diagnosis: a retrospective cohort study.

    Authors: Alessio Strazzulla; Paul Tarteret; Maria Concetta Postorino; Marie Picque; Astrid de Pontfarcy; Nicolas Vignier; Catherine Chakvetadze; Coralie Noel; Cecile Drouin; Zine Eddine Benguerdi; Sylvain Diamantis

    doi:10.21203/ Date: 2020-07-30 Source: ResearchSquare

    Background Access to molecular diagnosis was limited out-of-hospital in France during the 2020 coronavirus disease MESHD 2019 (COVID-19) epidemic. This study describes the evolution of COVID-19 outbreak in a nursing home in absence of molecular diagnosis. Methods A monocentric prospective study was conducted in a French nursing home from March 17th, 2020 to June 11th, 2020. Because of lack of molecular tests for severe acute respiratory syndrome MESHD 2 (SARS-Cov2) infection MESHD, probable COVID-19 cases were early identified considering only respiratory and not-respiratory symptoms and therefore preventing measures and treatments were enforced. Once available, serology tests were performed at the end of the study.A chronologic description of new cases and deaths MESHD was made together with a description of COVID-19 symptoms. Data about personal characteristics and treatments were collected and the following comparisons were performed: i) probable COVID-19 cases vs asymptomatic TRANS residents; ii) SARS-Cov2 seropositive residents vs seronegative residents. Results Overall, 32/66 (48.5%) residents and 19/39 (48.7%) members of health-care personnel were classified as probable COVID-19 cases. A total of 34/61 (55.7%) tested residents resulted seropositive. Death MESHD occurred in 4/66 (6%) residents. Diagnosis according to symptoms had 65% of sensitivity SERO, 78% of specificity, 79% of positive predictive value SERO and 64% of negative predictive value SERO.In resident population, the following symptoms were registered: 15/32 (46.8%) lymphopenia MESHD lymphopenia HP, 15/32 (46.8%) fever MESHD fever HP, 8/32 (25%) fatigue MESHD fatigue HP, 8/32 (25%) cough MESHD cough HP, 6/32 (18.8%) diarrhoea, 4/32 (12.5%) severe respiratory distress HP requiring oxygen therapy, 4/32 (12.5%) fall HP, 3/32 (9.4%) conjunctivitis MESHD conjunctivitis HP, 2/32 (6.3%) abnormal pulmonary noise at chest examination and 2/32 (6,25%) abdominal pain MESHD abdominal pain HP. Probable COVID-19 cases were older (81.3 vs 74.9; p=0.007) and they had higher prevalence SERO of atrial fibrillation MESHD atrial fibrillation HP (8/32, 25% vs 2/34, 12%; p=0.030); insulin treatment (4/34, 12% vs 0, 0%; p=0.033) and positive SARS-Cov2 serology (22/32, 69% vs 12/34, 35%; p=0.001) than asymptomatic TRANS residents. Seropositive residents had lower prevalence SERO of diabetes (4/34, 12% vs 9/27, 33%; p=0.041) and angiotensin-converting-enzyme inhibitors’ intake (1/34, 1% vs 5/27, 19%; p=0.042). Conclusions During SARS-Cov2 epidemic, early detection of respiratory and not-respiratory symptoms allowed to enforce extraordinary measures. They achieved limiting contagion and deaths MESHD among nursing home residents, even in absence of molecular diagnosis.

    Ocular findings and retinal involvement in COVID-19 pneumonia MESHD pneumonia HP patients: A cross-sectional study in an Italian referral centre

    Authors: Maria Pia Pirraglia; Giancarlo Ceccarelli; Alberto Cerini; Giacomo Visioli; Gabriella d'Ettorre; Claudio Maria Mastroianni; Francesco Pugliese; Alessandro Lambiase; Magda Gharbiya

    doi:10.21203/ Date: 2020-07-23 Source: ResearchSquare

    Background: changes in immune and coagulation systems and possible viral spread through blood SERO-brain barrier have been described in SARS-CoV-2 infection MESHD. In this study, we evaluate the possible retinal involvement and ocular findings in severe COVID-19 pneumonia MESHD pneumonia HP patients.  Methods: a cross sectional study was conducted on 46 patients affected by severe COVID-19 who were hospitalized in one Intensive Care Unit (ICU) and in two Infectious Diseases MESHD wards, including a bedside eye screening, corneal sensitivity SERO assessment and retinography. Results: a total of 43 SARS-CoV-2 positive pneumonia MESHD pneumonia HP patients affected with COVID-19 pneumonia MESHD pneumonia HP were included, 25 males TRANS and 18 females TRANS, with a median age TRANS of 70 [IQR 59-78]. Except for one patient with unilateral posterior chorioretinitis MESHD chorioretinitis HP of opportunistic origin, of whom aqueous tap was negative for SARS-CoV-2, no further retinal manifestation related to COVID-19 infection MESHD was found in our cohort. We found 3 patients (7%) with bilateral conjunctivitis MESHD conjunctivitis HP in whom PCR analysis on conjunctival swab provided negative results for SARS-CoV-2. No alterations of corneal sensitivity SERO were found.Conclusion: we demonstrated the absence of retinal involvement in SARS-CoV-2 pneumonia MESHD pneumonia HP patients. Ophthalmologic evaluation in COVID-19, particularly in patients hospitalized in an ICU setting, may be useful to reveal systemic co- infections by opportunistic MESHD infections by opportunistic HP pathogens. 

    Risk Factors Prediction, Clinical Outcomes, and Mortality of COVID-19 Patients

    Authors: Roohallah Alizadehsani; Zahra Alizadeh sani; Mohaddeseh Behjati; Zahra Roshanzamir; Sadiq Hussain; Niloofar Abedini; Fereshteh Hasanzadeh; Abbas Khosravi; Afshin Shoeibi; Mohamad Roshanzamir; Pardis Moradnejad; Saeid Nahavandi; Fahime Khozeimeh; Assef Zare; Maryam Panahiazar; U. Rajendra Acharya; Sheikh Mohammed Shariful Islam

    doi:10.1101/2020.07.07.20148569 Date: 2020-07-09 Source: medRxiv

    Background: Preventing communicable diseases MESHD requires understanding the spread, epidemiology, clinical features, progression, and prognosis of the disease MESHD. Early identification of risk factors and clinical outcomes might help to identify critically ill patients, provide proper treatment and prevent mortality. Methods: We conducted a prospective study in patients with flu-like symptoms referred to the imaging department of a tertiary hospital in IRAN between 3 March 2020 and 8 April 2020. Patients with COVID-19 were followed up to check their health condition after two months. The categorical data between groups were analyzed by Fisher exact test and continuous data by Wilcoxon Rank-Sum Test. Findings: 319 patients (mean age TRANS 45.48 years, 177 women) were enrolled. Fever MESHD Fever HP, dyspnea MESHD dyspnea HP, weakness, shivering HP, C-reactive protein (CRP), fatigue MESHD fatigue HP, dry cough MESHD cough HP, anorexia MESHD anorexia HP, anosmia HP, ageusia MESHD, dizziness MESHD, sweating and age TRANS were the most important symptoms of COVID-19 infection MESHD. Traveling TRANS in past three months, asthma MESHD asthma HP, taking corticosteroids, liver disease MESHD, rheumatological disease MESHD, cough MESHD cough HP with sputum, eczema MESHD eczema HP, conjunctivitis MESHD conjunctivitis HP, tobacco use, and chest pain MESHD chest pain HP did not have any relationship with COVID-19. Interpretation: Finding clinical symptoms for early diagnosis of COVID-19 is a critical part of prevention. These symptoms can help in the assessment of disease progression MESHD. To the best of our knowledge, some of the effective features on the mortality due to COVID-19 are investigated for the first time in this research. Funding: None

    Perception and Management of COVID-19 Among Allergic Children TRANS: An Italian Survey.

    Authors: Lucia Diaferio; Giuseppe Fabio Parisi; Giulia Brindisi; Cristiana Indolfi; Giuseppe Marchese; Daniele Giovanni Ghiglioni; Anna Maria Zicari; Gian Luigi Marseglia; Michele Miraglia del Giudice

    doi:10.21203/ Date: 2020-07-07 Source: ResearchSquare

    Background There is ample evidence that COVID-19 is significantly less severe in children TRANS than in adults TRANS and it has been reported that asthma MESHD asthma HP and allergy HP, the most prevalent chronic disorders in children TRANS, are not included in the top 10 comorbidities associated with COVID-19 fatalities. Nevertheless, there would seem that the concerns about asthma MESHD asthma HP and the risk of disease MESHD and related outcomes are still high. In order to assess these features, we conducted a 20-question anonymous internet-based survey among Italian paediatricians. Methods The questionnaire was conceived and pretested in April 2020, by a working group of experts of the Italian Paediatric Society for Allergy HP and Immunology (SIAIP).  The survey was emailed once between April and mid-May 2020. Participants were allowed to complete only a single survey.Results A total 99 participants had taken part in our survey and provided responses to our electronic questionnaire. The distribution of patients reported per month varies significantly according to the geographical area (P=0.02). Data confirmed that in the North part of Italy the rate of patients referred is higher than in the rest of Italy. Almost all respondents (98%) reported caring for up to a maximum of 10 infecting children TRANS and the last 2% more than twenty. Among these patients, according to the 75% of responders, a maximum rate of 20% were affected by allergic rhino- conjunctivitis MESHD conjunctivitis HP and in particular in the North of Italy while in the Centre and in the South there was a higher incidence (P=0.09). Almost the same applies for asthma MESHD asthma HP, 83% of responders declared that up to a maximum of 20% of affected children TRANS were asthmatic, from 20% to 40% for the 13,5% of responders and from 40% to 60% for the last 3,5%. As for the allergic conjunctivitis MESHD allergic conjunctivitis HP also for asthma MESHD asthma HP, we found a higher incidence in the Centre and in South than in the North (P=0.03).Conclusions This study is the first to provide a comprehensive review of COVID-19 knowledge and perceptions among paediatricians in Italy. From our point of view, it provides important information clearly useful for improving a good practice.

    The Prevalence SERO of ocular manifestations and ocular samples polymerase chain reaction positivity in patients with COVID 19 - a systematic review and meta-analysis

    Authors: Soumen Sadhu; Sushmitha Arcot Dandapani; Deepmala Mazumdar; Sangeetha Srinivasan; Jyotirmay Biswas

    doi:10.1101/2020.06.29.20142414 Date: 2020-06-30 Source: medRxiv

    Objective: To estimate the prevalence SERO of ocular manifestations and ocular samples polymerase chain reaction (PCR) positivity among COVID 19 patients. Methods: A systematic literature review was performed using search engines (PubMed, Google Scholar, Medrixv and BioRixv) with keywords SARS CoV 2, novel coronavirus, COVID 19, ocular manifestations, conjunctival congestion, Ocular detection, Polymerase chain reaction, and conjunctivitis MESHD conjunctivitis HP. The measure of heterogeneity was evaluated with the I2 statistic. The pooled proportion of patients presenting with symptoms and ocular samples PCR positivity was estimated. Results: A total of 20 studies (14 studies and 6 case reports) were included in the systematic review and 14 studies were included in the metaanalysis. The pooled prevalence SERO of conjunctivitis MESHD conjunctivitis HP was 5.17% (95% CI: 2.90 to 8.04). Conjunctivitis MESHD Conjunctivitis HP was reported as an initial symptom of the disease MESHD in 0.858 % (95% CI: 0.31 to 1.67). Common associated features include itching, chemosis HP, epiphora HP. Seven patients (29 %) with conjunctivitis MESHD conjunctivitis HP showed positive results in ocular samples, whereas 13 patients (54%) showed positive only in their nasopharyngeal samples (NPs) or sputum samples and 4 patients (16 %) were negative for both NPs and Sputum as well as ocular samples. The pooled prevalence SERO of ocular PCR positivity was 2.90 % (95% CI: 1.77 to 4.46) vs. NPs 89.8% (95% CI: 78.80 to 79.0). Conclusion: The prevalence SERO of conjunctivitis MESHD conjunctivitis HP and ocular samples PCR positivity among COVID 19 patients was low indicating that the eye is a less affected organ. However, conjunctivitis MESHD conjunctivitis HP may present as the first symptom of the disease MESHD making the patient seek medical care at the earliest.

    Alarming Symptoms Leading To Severe COVID-19 Pneumonia MESHD Pneumonia HP: A Meta-Analysis

    Authors: Weiping Ji; Jing Zhang; Gautam Bishnu; Xudong Du; Xinxin Chen; Hui Xu; Xiaoling Guo; Zhenzhai Cai; Jun Zhang; Xian Shen

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    Background: To identify alarming symptoms that could potentially lead to severe form of COVID-19 pneumonia MESHD pneumonia HP (i.e. novel coronavirus pneumonia MESHD pneumonia HP: NCP), a disease MESHD that is now having pandemic spread.Methods: Articles from PubMed, Embase, Cochrane database and Google up to 24 February 2020 were systematically reviewed. 18 publications that had documented cases of COVID-19 pneumonia MESHD pneumonia HP were identified. The relevant data were extracted, systematically reviewed and further evaluated using meta-analysis. We define severe COVID-19 pneumonia MESHD pneumonia HP as the disease MESHD status that requires admission to the intensive care unit (ICU) and respiratory/circulatory support, which is in align with the guideline from the World Health Organization (WHO).Results: 14 studies including 1,424 patients were considered eligible and analyzed. Symptoms such as fever MESHD fever HP (89.2%), cough MESHD cough HP (67.2%), fatigue MESHD fatigue HP (43.6%) were quite common; but dizziness MESHD, hemoptysis MESHD hemoptysis HP, abdominal pain MESHD abdominal pain HP and conjunctival congestion/ conjunctivitis MESHD conjunctivitis HP were relatively rare. The incidence of dyspnea MESHD dyspnea HP was significantly higher in patients with severe than non-severe COVID-19 pneumonia MESHD pneumonia HP (42.7% vs.16.3%, p<0.0001). Similarly, fever MESHD fever HP and diarrhea MESHD diarrhea HP were also drastically more common in patients with severe form (p=0.0374 and 0.0267). Further meta-analysis using three high-quality China-based studies confirmed such findings and showed that dyspnea MESHD dyspnea HP, fever MESHD fever HP and diarrhea MESHD diarrhea HP were 3.53 (OR: 3.53, 95%CI: 1.95-6.38), 1.70 (OR: 1.70, 95%CI: 1.01-2.87), and 1.80 (OR: 1.80, 95%CI: 1.06-3.03) folds higher respectively in patients with severe COVID-19 pneumonia MESHD pneumonia HP.Conclusion: Dyspnea MESHD Dyspnea HP, fever MESHD fever HP and diarrhea MESHD diarrhea HP are significantly more prevalent in patients with severe COVID-19 pneumonia MESHD pneumonia HP, suggesting they are alarming symptoms that warrant close attention and timely management.

    Sociodemographic profile, clinical characteristics, anxiety HP, and depression of 74 patients infected with COVID-19: first report from Bangladesh

    Authors: Dr. Mohammad Jahid Hasan; Dr. Md. Abdullah Saeed Khan; Dr. Monjur Rahman; Dr. Md. Shahnoor Islam; Dr Sourav Debnath; Dr. Jannatul Fardous,; Professor Dr. Mohammad Robed Amin

    doi:10.21203/ Date: 2020-05-30 Source: ResearchSquare

    Background: The pandemic of Corona Virus Disease MESHD 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence SERO of anxiety HP and depression among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age TRANS of 42.59±14.43 years with male TRANS predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever MESHD fever HP (77%), cough MESHD cough HP (58.8%), breathlessness (24.3%), myalgia MESHD myalgia HP (24.3%), sore throat (21.6%), fatigue MESHD fatigue HP (17.6%), nausea MESHD nausea and/or vomiting HP and/or vomiting MESHD (12.2%), headache MESHD headache HP (12.2%), runny nose (9.5%), chest pain MESHD chest pain HP (9.5%), diarrhea MESHD diarrhea HP (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis MESHD conjunctivitis HP (1.4%) and oral ulcer MESHD oral ulcer HP (1.4%). Overall, the prevalence SERO of anxiety HP and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety HP, 4.3% had only depression and 48.6% had both.Conclusion: Patients were mostly middle aged TRANS, male TRANS and healthy workers. Typical presentations were fever MESHD fever HP and cough MESHD cough HP. Nearly two-thirds of the patients had either or both anxiety HP and depression.

    COVID-19 receptor ACE2 is expressed in human conjunctival tissue, expecially in diseased conjunctival MESHD tissue

    Authors: shengjie li Sr.; danhui li; jianchen fang; qiang liu; xinghuai sun; gezhi xu; wenjun cao

    doi:10.1101/2020.05.21.20109652 Date: 2020-05-23 Source: medRxiv

    COVID-19 virus has currently caused major outbreaks worldwide. ACE2 is a major cellular-entry receptor for the COVID-19 virus. Although ACE2 is known to be expressed in many organs, whether it is expressed by the conjunctival tissue is largely unknown. Human conjunctival tissues from 68 subjects were obtained, which included 10 subjects with conjunctival nevi MESHD nevi HP, 20 subjects with conjunctivitis MESHD conjunctivitis HP, 9 subjects with conjunctival papilloma MESHD papilloma HP, 16 subjects with conjunctival cyst MESHD, 7 subjects with conjunctival polyps MESHD, and 6 ocular traumas as normal subjects. Expression of ACE2 was evaluated by immunohistochemistry, immunofluorescence, reverse transcriptase-quantitative polymerase chain reaction, and western blot assay. We observed the expression of ACE2 by conjunctival tissues, expecially in conjunctival epithelial cells. ACE2 was significantly (p<0.001) overexpressed in conjunctival cells obtained from subjects with conjunctivitis MESHD conjunctivitis HP, conjunctival nevi MESHD nevi HP, conjunctival papilloma MESHD papilloma HP, conjunctival cyst MESHD, and conjunctival polyps MESHD epithelial cells when compared to that in conjunctival epithelial cells obtained from control subjects. Collectively, clinical features of reported COVID-19 patients combined with our results indicate that COVID-19 is likely to be transmitted through the conjunctiva.

    Multisystem inflammatory syndrome MESHD with features of Atypical Kawasaki disease MESHD during COVID-19 pandemic: Report of a case from India

    Authors: Abdul Rauf; Ajay Vijayan; Shaji Thomas John; Raghuram A Krishnan; Abdul Latheef

    doi:10.21203/ Date: 2020-05-15 Source: ResearchSquare

    There is a global concern of increasing number of children TRANS presenting with inflammatory syndrome MESHD with clinical features simulating Kawasaki disease MESHD, during ongoing COVID-19 pandemic. We report a very similar case of 5-year-old boy from a COVID-19 hotspot area in Kerala state of India who presented in late April 2020 with acute febrile illness with abdominal pain MESHD abdominal pain HP and loose stools followed by shock MESHD shock HP. On examination, child TRANS had bulbar conjunctivitis MESHD conjunctivitis HP and extremity edema MESHD edema HP. Initial investigations showed high inflammatory parameters, elevated serum creatinine HP serum SERO creatinine and liver enzymes. Echocardiography showed moderate LV dysfunction and normal coronaries. Cardiac enzymes were also elevated, suggesting myocarditis MESHD myocarditis HP. He was treated with inotropic support, respiratory support with High Flow Nasal Cannula, IV Immunoglobulins, aspirin, steroids and diuretics. RT PCR for SARS-CoV-2 was negative twice. His clinical condition improved rapidly, was afebrile from day 2, inflammatory parameters decreased, left ventricular function improved and was discharged after 6 days of hospital stay.

    COVID-19 experience: first Italian survey on healthcare staff members from a Mother- Child TRANS Research hospital using combined molecular and rapid immunoassays SERO test

    Authors: Manola Comar; Marco Brumat; Maria Pina Concas; Giorgia Argentini; Annamonica Bianco; Livia Bicego; Roberta Bottega; Petra Carli; Andrea Cassone; Eulalia Catamo; Massimiliano Cocca; Massimo Del Pin; Mariateresa Di Stazio; Agnese Feresin; Martina La Bianca; Sara Morassut; Anna Morgan; Giulia Pelliccione; Vincenzo Petix; Giulia Ragusa; Antonietta Robino; Stefano Russian; Beatrice Spedicati; Sarah Suergiu; Marianela Urriza; Fulvia Vascotto; Paola Toscani; Giorgia Girotto; Paolo Gasparini

    doi:10.1101/2020.04.19.20071563 Date: 2020-04-22 Source: medRxiv

    The fast spread of the novel coronavirus (SARS-CoV-2) has become a global threat hitting the worldwide fragile health care system. In Italy, there is a continued COVID-19 growth of cases and deaths MESHD that requires control measures for the correct management of the epidemiological emergency MESHD. To contribute to increasing the overall knowledge of COVID-19, systematic tests in the general population are required. Here, we describe the first Italian survey performed in 727 employees belonging to a Mother- Child TRANS Research hospital tested for both viral (nasopharyngeal and oropharyngeal swabs) and antibody SERO presence. Individuals were divided into three risk categories (high, medium and low) according to their job activity. Only one subject was positive at the swab test while 17.2% of the cohort was positive for the presence of antibodies SERO. Results highlighted that the presence of Positive antibodies SERO is significantly associated with high and medium risk exposure occupation (p-value=0.026) as well as cold and conjunctivitis MESHD conjunctivitis HP symptoms (p-value=0.016 and 0.042 respectively). Moreover, among healthcare professionals, the category of medical doctors showed a significant association with the presence of antibodies SERO against SARS-CoV-2 (p-value=0.0127). Finally, we detected a rapid decrease in antibody SERO intensity between two assessments performed within a very short period (p-value=0.009). Overall, the present study increases our knowledge of the epidemiological data of COVID-19 infection MESHD in Italy, suggesting a high prevalence SERO of immune individuals (i.e. at least among at-risk categories) and the efficacy of the combined diagnostic protocol to monitor the possible outbreak.

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MeSH Disease
Human Phenotype

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