Background: Coronavirus has spread rapidly around the world. This epidemic has created stress and anxiety HP for pregnant women in different parts of the world. The aim of this study was to investigate the relationship between quality of life (QoL) with anxiety HP, depression, corona disease MESHD anxiety HP, sexual function (SF), and marital satisfaction (MS) in pregnant women during the Covid-19 pandemic.Methods: The present study is a cross-sectional study involving 260 pregnant women. The Short-Form Health Survey (SF_12), Marital Satisfaction Scale (MSS), Female TRANS Sexual Function Index (FSFI), Hospital Anxiety HP and Depression Scale (HADS), and coronary disease MESHD anxiety HP questionnaire, Padua Obsession Questionnaire, General Health Questionnaire (GHQ) are used for data collection. Data were analyzed using the Pearson correlation coefficient and path analysis.Result: The overall goodness-of-fit statistics revealed that the predictors of QOL had perfectly good fitness indices (RMSEA=0.02; AGFI=0.99). The results show that corona related anxiety HP, marital satisfaction (MS), sexual function (SF), depression, and anxiety HP have a direct effect on women’s QOL. Among variables, GHQ has a more direct effect on women’s QOL. General health (GH) considered as a mediator variable; variables such as anxiety HP, depression, and Corona-related Anxiety HP with effect on GH can impress QOL. Anxiety HP as a main predictor of QOL, with direct, and indirect effects through GH, depression, SF, and MS can impress QOL. Conclusion: Since the QoL in pregnant women is associated with coronavirus epidemics, these results can be used to plan to improve the health and QoL of these people.