Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    SARS-CoV-2 protein Nsp1 alters actomyosin cytoskeleton and phenocopies arrhythmogenic cardiomyopathy MESHD cardiomyopathy HP-related PKP2 mutant

    Authors: Cristina Marquez-Lopez; Marta Roche-Molina; Nieves García-Quintáns; Silvia Sacristan; David Siniscalco; Andrés Gonzalez-Guerra; Emilio Camafeita; Mariya Lytvyn; María Isabel Guillén; David Sanz-Rosa; Daniel Martín-Pérez; Cristina Sanchez-Ramos; Ricardo Garcia; Juan Antonio Bernal; Sijia Tao; Tristan R Horton; Elizabeth N Beagle; Ernestine A Mahar; Michelle YH Lee; Joyce Cohen; Sherrie Jean; Jennifer S Wood; Fawn Connor-Stroud; Rachelle L Stammen; Olivia M Delmas; Shelly Wang; Kimberly A Cooney; Michael N Sayegh; Lanfang Wang; Daniela Weiskopf; Peter D Filev; Jesse Waggoner; Anne Piantadosi; Sudhir P Kasturi; Hilmi Al-Shakhshir; Susan P Ribeiro; Rafick P Sekaly; Rebecca D Levit; Jacob D Estes; Thomas H Vanderford; Raymond F Schinazi; Steven E Bosinger; Mirko Paiardini

    doi:10.1101/2020.09.14.296178 Date: 2020-09-16 Source: bioRxiv

    Mutations in desmosomal Plakophilin-2 (PKP2) are the most prevalent drivers of arrhythmogenic-cardiomyopathy MESHD cardiomyopathy HP ( ACM MESHD) and a common cause of sudden death MESHD in young athletes. However, partner proteins that elucidate PKP2 cellular mechanism behind cardiac dysfunction MESHD in ACM MESHD are mostly unknown. Here we identify the actin-based motor proteins Myh9 and Myh10 as key PKP2 interactors and demonstrate that expression of the ACM MESHD-related PKP2 mutant R735X alters actin fiber organization and cell mechanical stiffness. We also show that SARS-CoV-2 Nsp1 protein acts similarly to this known pathogenic R735X mutant, altering the actomyosin component distribution on cardiac cells. Our data reveal that Nsp1 hijacks PKP2 into the cytoplasm and mimics the effect of delocalized R735X mutant. These results demonstrate that cytoplasmic PKP2 drives actomyosin deregulation and structural collapse, validating a critical role of PKP2 localization in the regulation of actomyosin architecture. The fact that Nsp1 and R735X share similar phenotypes also suggests that direct SARS-CoV-2 heart infection MESHD could induce a transient ACM MESHD-like disease in COVID-19 patients, which may contribute to right ventricle dysfunction, observed in patients with poor prognosis.

    Predictive value of sudden olfactory loss MESHD in the diagnosis of COVID-19

    Authors: Antje Haehner; Julia Draf; Sarah Draeger; Katja de With; Thomas Hummel

    doi:10.1101/2020.04.27.20081356 Date: 2020-05-03 Source: medRxiv

    Introduction: Recent reports suggest that sudden smell loss might be a symptom of SARS-CoV-2 infection MESHD. The aim of this study was to investigate the frequency of olfactory loss MESHD in an out-patient population who presented to a coronavirus testing center during a 2-week period and to evaluate the diagnostic value of the symptom sudden smell loss for screening procedures. Methods: In this cross-sectional controlled cohort study, 500 patients who presented with symptoms of a common cold to a corona testing center and fulfilled corona testing criteria, completed a standardized diagnostic questionnaire which included the patients main symptoms, time course and an additional self-assessment of the patients current smell, taste function and nasal breathing compared to the level before onset of symptoms TRANS. Results: Out of the 500 patients, 69 presented with olfactory loss MESHD. Twenty-two of them subsequently tested positive for SARS-CoV-2. Only twelve out of the patients without olfactory loss tested positive, resulting in a frequency of 64.7% for the symptom sudden smell loss in COVID-19 patients. Compared to COVID-19 patients without smell loss, they were significantly younger and less severely affected. Changes in nasal airflow were significantly more pronounced in SARS-CoV-2 negative patients with olfactory complaints compared to the patients with smell loss who were tested positive for SARS-CoV-2. By excluding patients with a blocked nose, the symptom sudden smell loss can be attested a high specificity (97%) and a sensitivity SERO of 65% with a PPV of 63% and NPV of 97% for COVID-19. Conclusion: Considering the high frequency of smell loss in non-hospitalized COVID-19 patients, acute olfactory impairment MESHD should be included in the WHO symptoms list and should be recognized as an early symptom of the disease. In contrast to other acute viral smell impairment, COVID-19 associated smell loss seems to be only rarely accompanied by a severely blocked nose.

    Factors related to COVID-19 severity and mortality based on comparison between Henan and Zhejiang: an observational study

    Authors: Wangquan Ji; Ruonan Liang; Peiyu Zhu; Haiyan Yang; Shuaiyin Chen; Weiguo Zhang; Yuefei Jin; Guangcai Duan

    doi:10.21203/rs.3.rs-24420/v1 Date: 2020-04-22 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) has spread across China and the world, since outbreak at the end of 2019. Although COVID-19 is generally considered as self-limiting, some of cases develop in to fatal respiratory restress, multiple organ failure MESHD and even sudden death MESHD. According to the data released by the provincial health commissions, there are obvious regional differences in COVID-19 mortality. To explore possible factors of COVID-19 related severity and mortality in laboratory- confirmed cases TRANS from Henan and Zhejiang.Methods: We collected the public data released by the government. We analyzed and compared the possible factors, including initial symptoms, gender TRANS, age TRANS, place of residence, time interval from onset to diagnosis, epidemiological history and the grade of hospital for patient’s treatment in laboratory- confirmed cases TRANS. Student’s t-test, Chi-square (c2) test, Cochran-Mantel-Haenszel (CMH) test and Mann-Whitney U rank sum test were used complied with the applicable conditions. Statistical test was performed with a level of significance α=0.05.Results: Death cases in Henan were mainly from male TRANS, elderly TRANS infected persons and those who had a history of contact with patients and underlying basic diseases. Henan had the higher proportion of cases with fever HP fever MESHD and the lower proportion of asymptomatic TRANS infection MESHD, and had higher proportions of imported male TRANS cases with a contact history, and elderly TRANS cases living in rural areas, relative to Zhejiang. The time interval of confirmed cases TRANS in rural areas of Henan was 0.8 day longer than that in Zhejiang. Hospitals grade for patients’ treatment in Henan was lower than Zhejiang.Conclusions: Our findings suggest that initial symptoms, age TRANS, place of residence, gender TRANS, the time interval from onset to diagnosis and the grade of designated hospital for patient’s treatment are possible factors behind COVID-19 related severity or mortality. This study will provide useful information for public health authorities to develop disease prevention strategies.

    Factors related to COVID-19 severity and mortality based on comparison between Henan and Zhejiang: an observational study

    Authors: Wangquan Ji; Ruonan Liang; Peiyu Zhu; Haiyan Yang; Shuaiyin Chen; Weiguo Zhang; Yuefei Jin; Guangcai Duan

    doi:10.21203/rs.3.rs-18191/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) has spread across China and the world, since outbreak at the end of 2019. Although COVID-19 is generally considered as self-limiting, some of cases develop in to fatal respiratory restress, multiple organ failure MESHD and even sudden death MESHD. According to the data released by the provincial health commissions, there are obvious regional differences in COVID-19 mortality. To explore possible factors of COVID-19 related severity and mortality in laboratory- confirmed cases TRANS from Henan and Zhejiang.Methods: We collected the public data released by the government. We analyzed and compared the possible factors, including initial symptoms, gender TRANS, age TRANS, place of residence, time interval from onset to diagnosis, epidemiological history and the grade of hospital for patient’s treatment in laboratory- confirmed cases TRANS. Student’s t-test, Chi-square (2) test, Cochran-Mantel-Haenszel (CMH) test and Mann-Whitney U rank sum test were used complied with the applicable conditions. Statistical test was performed with a level of significance α=0.05.Results: Death cases in Henan were mainly from male TRANS, elderly TRANS infected persons and those who had a history of contact with patients and underlying basic diseases. Henan had the higher proportion of cases with fever HP fever MESHD and the lower proportion of asymptomatic TRANS infection MESHD, and had higher proportions of imported male TRANS cases with a contact history, and elderly TRANS cases living in rural areas, relative to Zhejiang. The time interval of confirmed cases TRANS in rural areas of Henan was 0.8 day longer than that in Zhejiang. Hospitals grade for patients’ treatment in Henan was lower than Zhejiang.Conclusions: Our findings suggest that initial symptoms, age TRANS, place of residence, gender TRANS, the time interval from onset to diagnosis and the grade of designated hospital for patient’s treatment are possible factors behind COVID-19 related severity or mortality. This study will provide useful information for public health authorities to develop disease prevention strategies.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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