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MeSH Disease

Human Phenotype

Transmission

Seroprevalence

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    The Writing On The Wall Intravitreal Injection Compliance During The COVID-19 Pandemic and Its Foreseeable Consequences

    Authors: Lauren M Wasser; Yishay Weill; Koby Brosh; Itay Magal; Michael Potter; Israel Strassman; Evgeny Gelman; Meni Koslowsky; David Zadok; Joel Hanhart

    doi:10.21203/rs.3.rs-53248/v1 Date: 2020-08-04 Source: ResearchSquare

    Background: Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) agents have become the most prevalent intraocular procedure as they represent the major therapeutic modality for prevalent retinal conditions such as age TRANS-related macular degeneration MESHD macular degeneration HP (AMD) and diabetic retinopathy MESHD retinopathy HP. Effective therapy requires adherence to a schedule of iterative IVI as well as routine clinic appointments. The ongoing Coronavirus disease MESHD 2019 (COVID-19) pandemic has resulted in the reduction of attendance at scheduled clinics visits and IVI. In this study we attempted to analyze the effect of COVID-19 on compliance with anti-VEGF therapy.Methods: A total of 636 eyes received injections during a four-week period of the COVID-19 outbreak in the Retina Clinic. The number of clinic visits for IVI during one month from March 15 to April 14 of 2020 was compared to the similar time period in each of the last four years.Results: The study demonstrates a decrease in clinic visits for IVI when compared with the same four-week interval in the four previous years. Based on the trend of the previous four years, 10.2% of the year’s total was expected for this time period. Using this model, the 636 reported number of injections for the March-April, 2020 period was ~ 5%. This represents a decrease of ~50% of the expected IVI for this time period.Conclusion: The COVID-19 outbreak in Israel severely impacted compliance with anti-VEGF treatments.

    Diabetic Retinopathy MESHD Retinopathy HP Screening in Urban Primary Care Setting with a Handheld Smartphone-based Retinal Camera.

    Authors: Márcia S Queiroz; Jacira Xavier de Carvalho; Silvia Ferreira Bortoto; Mozania Reis de Matos; Cristiane das Graças Dias Cavalcante; Elenilda Almeida Silva Andrade; Maria Lúcia Correa-Giannella; Fernando K Malerbi

    doi:10.21203/rs.3.rs-35818/v1 Date: 2020-06-15 Source: ResearchSquare

    Aims: To evaluate diabetic retinopathy MESHD retinopathy HP (DR) screening with a portable handheld smartphone-based retinal camera and telemedicine in an urban primary health care setting; to evaluate the learning curve for image acquisition, performed by healthcare personnel without previous experience on retinal imaging. Methods: Prospective study that enrolled patients with type 2 diabetes mellitus MESHD diabetes mellitus HP (T2DM) followed at a primary healthcare unit in São Paulo, Brazil. After a brief training in image acquisition, there was further continuous feedback during the remote image reading process. Each patient underwent two fundus and one anterior ocular segment images per eye, after mydriasis MESHD mydriasis HP. Patients were classified according need of referral. Results: A total of 627 adult TRANS individuals with T2DM underwent retinal evaluation. The population was composed by 63.2% female TRANS individuals, age TRANS median of 66 years-old, diabetes duration 10.7 ± 8.2 years and A1c 7.7 ± 1.9% (61 + 20.8 mmol/mol). The most prevalent associated comorbidities were arterial hypertension MESHD hypertension HP (80.3%) and dyslipidemia (50.2%). Referral decision was possible in 81.2% patients. Most patients had absent or non-referable DR; the main ocular media opacity detected was cataract MESHD cataract HP. After the 7th day of image acquisition, the daily rate of patients whose images allowed clinical decision was maintained above 80%. A higher A1c was associated with referable DR. Conclusion: A low-cost DR screening strategy with a handheld device and telemedicine is feasible and has the potential to increase coverage of DR screening in underserved areas; the possibility of mobile units is relevant for DR screening in the context of Covid-19 pandemic.

    Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study

    Authors: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun

    doi:10.1101/2020.03.12.20034678 Date: 2020-03-16 Source: medRxiv

    Objective: The novel coronavirus disease MESHD (COVID-19) was first reported in Wuhan, China in December 2019 and is now pandemic all over the world. Previous study has reported several COVID-19 cases with conjunctivitis MESHD conjunctivitis HP. However, the complete profiling of COVID-19 related ocular symptoms and diseases MESHD are still missing. We aim to investigate the ocular manifestations and clinical characteristics of COVID-19 patients. Methods: A total of five hundred and thirty-four patients were recruited at Mobile Cabin Hospital and Tongji Hospital. We collected information on demographic characteristics, exposure history, ocular symptoms, systemic concomitant symptoms, eye drop medication, eye protections, radiologic findings, and SARS-CoV-2 detection in nasopharyngeal swabs by RT-PCR from questionnaires and electronic medical records. Results: The median age TRANS of patients was 40 and 50 years at Mobile Cabin Hospital and Tongji Hospital, respectively. Of 534 COVID-19 patients, 25 patients (4.68%) presented with conjunctival congestion and 3 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 4.9 {+/-} 2.6 days (mean [SD]), ranging from 2 to 10 days. Dry eye (112, 20.97%), blurred vision HP (68, 12.73%), and foreign body MESHD sensation (63, 11.80%) ranked as the top three COVID-19 related ocular symptoms. Notably, a total of 332 COVID-19 patients (62%) had a hand-eye contact history. We also found that some COVID-19 patients had a history of eye disease MESHD, including conjunctivitis MESHD conjunctivitis HP (33, 6.18%), dry eye (24, 4.49%), keratitis MESHD keratitis HP (14, 2.62%), cataract MESHD cataract HP (9, 1.69%), and diabetic retinopathy MESHD retinopathy HP (5, 0.94%). In consistent with previous studies, the most common clinical symptoms were fever MESHD fever HP, cough MESHD cough HP, and fatigue MESHD fatigue HP. Patients, 60.5% in Mobile Cabin Hospital and 67.5% in Tongji Hospital, respectively were confirmed with positive SARS-CoV-2 detection. Conclusions: Conjunctival congestion was one of the COVID-19 related ocular symptoms, which may have clinical diagnostic significance. It is essential to provide eye-care equipment and strengthen education on eye protection, as dirty hand-eye contact might be a high risk factor of COVID-19. Further detailed and comprehensive ophthalmological guidance is needed for COVID-19 control.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
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