Corpus overview


Overview

MeSH Disease

Diphtheria (3)

Tetanus (3)

Infections (2)

Death (2)

Measles (2)


Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Possible Cross-Reactivity Between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease MESHD and Death MESHD

    Authors: Robert Root-Bernstein

    id:10.20944/preprints202007.0141.v2 Date: 2020-08-04 Source: Preprints.org

    Various studies indicate that vaccination, especially with pneumococcal vaccines, protects against symptomatic cases of SARS-CoV-2 infection MESHD and death MESHD. This paper explores the possibility that pneumococcal vaccines in particular, but perhaps other vaccines as well, contain antigens that might be cross-reactive with SARS-CoV-2 antigens. Comparison of the glycosylation structures of SARS-CoV-2 with the polysaccharide structures of pneumococcal vaccines yielded no obvious similarities. However, while pneumococcal vaccines are primarily composed of capsular polysaccharides, some are conjugated to CRM197, a modified diphtheria MESHD toxin, and all contain about three percent protein contaminants, including the pneumococcal surface proteins PsaA, PspA and probably PspC. All of these proteins have very high degrees of similarity, using very stringent criteria, with several SARS-CoV-2 proteins including the spike protein, membrane protein and replicase 1a. CRM197 is also present in Hib and meningitis MESHD meningitis HP vaccines. Equivalent similarities were found at statistically significantly lower rates, or were completely absent, among the proteins in diphtheria MESHD, tetanus MESHD, pertussis, measles MESHD, mumps MESHD, rubella MESHD, and poliovirus vaccines. Notably, PspA and PspC are highly antigenic and new pneumococcal vaccines based on them are currently in human clinical trials so that their effectiveness against SARS-CoV-2 disease MESHD is easily testable.

    Do childhood measles MESHD and DTaP vaccination decrease the mortality rate caused by SARS CoV-2 in OECD countries?: An Epidemiologic Study

    Authors: Ramazan Guven; Muhammed Ikbal Sasmaz; Gokhan Eyupoglu; Seda Yilmaz Semerci

    doi:10.21203/rs.3.rs-48106/v1 Date: 2020-07-23 Source: ResearchSquare

    Background The mortality rates caused by SARS CoV-2 differ between countries and this difference might be explained by several reasons. Childhood vaccination rate is thought to be one of them. Therefore, present study aimed to examine the possible relationship between DTaP ( diphtheria MESHD, tetanus MESHD, acellular pertussis vaccine) and measles MESHD vaccination rates of Organization for Economic Co-operation and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.Methods A total of 32 OECD countries, of northern hemisphere, have been included in this study. Statistical analysis performed according to the CFR data of these countries based on SARS CoV-2. The CFR data calculated according to the total mortality count of a specific country for the 3-month period down from the date when first SARS CoV-2 case was observed. Results Based on the correlation levels of vaccination rates of OECD countries with a period of 3-month CFR, a strong negative correlation of significance between CFR and measles MESHD (r=-0.479, p=0.006) were pointed, while a negative but not significant correlation were seen between CFR and DTaP vaccination rates (r=-264.0, p=0.145). Conclusion Depending on the results of the study, lower CFR based on COVID-19, is suggested to be related to the successful vaccination rates of those OECD countries. Therefore, further effort is required to improve rates of childhood vaccination not only for specified diseases MESHD, but either possible protection against COVID-19 worldwide. Trial Registration: This study is registered to clinicaltrials.gov with trial number: NCT04468802.

    Worldwide inverse correlation between Bacille Calmette-Guérin immunization and COVID-19 morbidity and mortality

    Authors: Willis X. Li

    doi:10.21203/rs.3.rs-42927/v1 Date: 2020-07-14 Source: ResearchSquare

    The COVID-19 pandemic has spread to all countries in the world after more than six months since it was first reported in late 2019, and different countries have been impacted differently.  Correlation analysis between COVID-19 death MESHD numbers and different demographic and socioeconomic factors for all world countries (n=210) as of June 1, 2020, reveals that COVID-19 deaths MESHD per million population in a country significantly correlates with the country’s median age TRANS (r=0.48, p=4.8e-4) and per capita gross domestic product (GDP) (r=0.55, p=4.14e-5), and inversely correlates with the country’s Bacille Calmette-Guérin (BCG) vaccination rate (r=–0.63, p=9.9e-7). COVID-19 death MESHD is found not significantly associated, however, with a country’s policy stringency index, population density, extreme poverty rate, hospital beds availability per thousand people, and diphtheria MESHD- tetanus MESHD-pertussis (DTP3) immunization. Old age TRANS is likely a confounding factor for the correlation between COVID-19 and per capita GDP (r=0.66, p=2.3e-7). To control for possible confounding effects of age TRANS, countries with similar median age were grouped TRANS and analyzed. The inverse correlation between BCG vaccination rates and COVID-19 case (r=–0.338, p=0.0082) and death MESHD (r=–0.411, p=0.0011) remained significant among the top 61 countries with highest median age TRANS.  The current study suggests that BCG might be protective against SARS-CoV-2 infection MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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