The technology-driven world of the 21st century is currently confronted with a major threat to humankind in the form of the coronavirus disease MESHD (COVID-19) pandemic, caused by the severe acute respiratory syndrome MESHD coronavirus-2 (SARS-CoV-2). As of April 22, 2020, COVID-19 has claimed 169, 006 human lives and had spread to over 200 countries with more than 2,471,136 confirmed cases TRANS. The perpetually increasing figures associated with COVID-19 are disrupting the social and economic systems globally. The losses are unmatched and significantly higher compared to those from previously encountered pathogenic infections MESHD. Previously, two CoVs (SARS-CoV and Middle East respiratory syndrome MESHD-CoV) affected the human population in 2002 and 2012 in China and Saudi Arabia, respectively. Based on genomic similarities, animal-origin CoVs, primarily those infecting bats, civet cats, and pangolins, were presumed to be the source of emerging human CoVs, including the SARS-CoV-2. The cohesive approach amongst virologists, bioinformaticians, big data analysts, epidemiologists, and public health researchers across the globe has delivered high-end viral diagnostics. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. The rapidly evolving and popular technology of artificial intelligence played a major role in confirming and countering the COVID-19 pandemic using digital technologies and mathematical algorithms. In this review, we discuss the noteworthy advancements in the mitigation of the COVID-19 pandemic, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease MESHD epidemiology, animal reservoirs, laboratory animal models, disease MESHD transmission TRANS, diagnosis using artificial intelligence interventions, therapeutics and vaccines, and disease MESHD mitigation measures to combat disease MESHD dissemination.