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SARS-CoV-2 proteins

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    An Expectation-Based Network Scan Statistic for a COVID-19 MESHD Early Warning System

    Authors: Chance Haycock; Edward Thorpe-Woods; James Walsh; Patrick O'Hara; Oscar Giles; Neil Dhir; Theodoros Damoulas

    id:2012.07574v1 Date: 2020-12-08 Source: arXiv

    One of the Greater London Authority's ( GLA HGNC) response to the COVID-19 pandemic MESHD brings together multiple large-scale and heterogeneous datasets capturing mobility, transportation and traffic activity over the city of London to better understand 'busyness' and enable targeted interventions and effective policy-making. As part of Project Odysseus we describe an early-warning system and introduce an expectation-based scan statistic for networks to help the GLA HGNC and Transport for London, understand the extent to which populations are following government COVID-19 MESHD guidelines. We explicitly treat the case of geographically fixed time-series data located on a (road) network and primarily focus on monitoring the dynamics across large regions of the capital. Additionally, we also focus on the detection and reporting of significant spatio-temporal regions. Our approach is extending the Network Based Scan Statistic ( NBSS MESHD) by making it expectation-based ( EBP HGNC) and by using stochastic processes for time-series forecasting, which enables us to quantify metric uncertainty in both the EBP HGNC and NBSS frameworks. We introduce a variant of the metric used in the EBP HGNC model which focuses on identifying space-time regions in which activity is quieter than expected.

    High prevalence of deep venous thrombosis in non-severe COVID-19 MESHD patients hospitalized for a neurovascular disease

    Authors: Olivier Rouyer; Irene-Nora Pierre-Paul; Amadou Balde; Damaris Jupitet; Daniela Bindila; Bernard Geny; Valerie Wolff

    doi:10.1101/2020.09.03.20187344 Date: 2020-09-05 Source: medRxiv

    Abstract Introduction: Severe SARS-CoV-2 infection MESHD, responsible for COVID-19 MESHD, is accompanied by venous thromboembolic MESHD events particularly in intensive care unit. In non-severe COVID-19 MESHD patients affected by neurovascular diseases MESHD, the prevalence of deep venous thrombosis MESHD ( DVT MESHD) is unknown. The aim of or study was to report data obtained after systematic Doppler ultrasound scanning ( DUS MESHD) of lower limbs in such patients. Methods: Between March 20 and May 2, 2020, consecutive patients with neurovascular diseases MESHD with non-severe COVID-19 MESHD were investigated with a systematic bedside DUS. Results Thirteen patients were enrolled including 10 acute ischemic strokes MESHD, one transient ischemic MESHD attack, one cerebral venous thrombosis MESHD and one haemorrhagic stroke MESHD. At admission, the median National Institute of Health Stroke MESHD Scale (NIHSS) was of 6 (IQR, 0-20). We found a prevalence of 38.5% of asymptomatic calves DVT MESHD (n=5) during the first week after admission despite thromboprophylaxis. Among them, one patient had a symptomatic pulmonary embolism MESHD. Two patients died during hospitalization but the outcome was favourable in the others with a discharge median NIHSS of 1 (IQR, 0-11). Discussion/Conclusion: Despite thromboprophylaxis, systematic bedside DUS showed a high prevalence of 38.5% of DVT MESHD in non-severe COVID-19 MESHD patients with neurovascular diseases MESHD. Therefore, we suggest that this non-invasive investigation should be performed in all patients of this category.

    The clinical spectrum of encephalitis in COVID-19 MESHD disease: the ENCOVID multicentre study

    Authors: Andrea Pilotto; Stefano Masciocchi; Irene Volonghi; Elisabetta del Zotto; Eugenio Magni; Valeria De Giuli; Francesca Caprioli; Nicola Rifino; Maria Sessa; Michele Gennuso; Maria Sofia Cotelli; Marinella Turla; Ubaldo Balducci; Sara Mariotto; Sergio Ferrari; Alfonso Ciccone; Fabrizio Fiacco; Alberto Imarisio; Barbara Risi; Alberto Benussi; Emanuele Foca'; Francesca Caccuri; Matilde Leonardi; Roberto Gasparotti; Francesco Castelli; Gianluigi Zanusso; Alessandro Pezzini; Alessandro Padovani

    doi:10.1101/2020.06.19.20133991 Date: 2020-06-20 Source: medRxiv

    Background: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection MESHD. Some sparse case reports have described various forms of encephalitis MESHD in COVID-19 MESHD disease, but very few data have focused on clinical presentations, clinical course, response to treatment and outcomes yet. Objective: to describe the clinical phenotype, laboratory and neuroimaging findings of encephalitis MESHD associated with SARS-CoV-2 infection MESHD, their relationship with respiratory function and inflammatory parameters and their clinical course and response to treatment. Design: The ENCOVID multicentre study was carried out in 13 centres in northern Italy between February 20th and May 31st, 2020. Only patients with altered mental status and at least two supportive criteria for encephalitis MESHD with full infectious screening, CSF HGNC, EEG, MRI data and a confirmed diagnosis of SARS-CoV-2 infection MESHD were included. Clinical presentation and laboratory markers, severity of COVID-19 MESHD disease, response to treatment and outcomes were recorded. Results: Out of 45 cases screened, twenty-five cases of encephalitis MESHD positive for SARS-CoV-2 infection MESHD with full available data were included. The most common symptoms at onset were delirium MESHD (68%), aphasia/dysarthria MESHD (24%) and seizures MESHD (24%). CSF HGNC showed hyperproteinorrachia and/or pleocytosis MESHD in 68% of cases whereas SARS-CoV-2 RNA by RT-PCR resulted negative. Based on MRI, cases were classified as ADEM (n=3), limbic encephalitis MESHD (LE, n=2), encephalitis MESHD with normal imaging (n=13) and encephalitis MESHD with MRI alterations (n=7). ADEM and LE cases showed a delayed onset compared to the other encephalitis MESHD (p=0.001) and were associated with previous more severe COVID-19 MESHD respiratory involvement. Patients with MRI alterations exhibited worse response to treatment and final outcomes compared to other encephalitis MESHD. Conclusions and relevance: We found a wide clinical spectrum of encephalitis MESHD associated with COVID19 MESHD infection, underlying different pathophysiological mechanisms. Response to treatment and final outcome strongly depended on specific CNS-manifestations.

    The 2019 novel coronavirus disease MESHD with secondary ischemic stroke: two cases report

    Authors: Bin Fu; Yun Chen; Ping Li

    doi:10.21203/rs.3.rs-20943/v2 Date: 2020-04-02 Source: ResearchSquare

    Background: The 2019 novel coronavirus disease MESHD is an outbreak of respiratory illness MESHD first detected in Wuhan, China in the end of Dec, 2019. The older patients complicated with underlying diseases MESHD are reported more likely to have clinical symptoms. But its secondary lesion is rarely reported. Case presentation: We reported two cases of coronavirus infected pneumonia MESHD with acute ischemic stroke MESHD in patients at their middle-age. In both 2019 coronavirus diseases MESHD cases, neurological physical examination are normal before infection. Lymphocytopenia MESHD and high expression of cytokines and D-dimer were found from serum clinical laboratory test at admission. The dysarthria MESHD and limb muscle weakness MESHD are initial manifestations in one week after 2019 novel coronavirus infection MESHD. The head CT and head/neck arterial CTA showed small-vessel occlusion MESHD. The patients were diagnosed with coronavirus diseases MESHD with secondary acute ischemic stroke MESHD. They were treated with tirofiban and followed up with daily aspirin and atorvastatin. Conclusion: The present cases suggested that secondary ischemic stroke MESHD, which mainly manifested as small-vessel occlusion MESHD, should be considered for coronavirus disease patients with prompt diagnosis and treatment. 

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