Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Time-dependent management of Hirschsprung disease MESHD during Covid-19 pandemic

    Authors: Alessio Pini Prato; Rossella Arnoldi; Maria Grazia Faticato; Enrico Felici; Paolo Nozza

    doi:10.21203/ Date: 2020-04-19 Source: ResearchSquare

    INTRODUCTION – During Covid-19 pandemic, some elective non-deferrable surgical procedures has been maintained on a local basis to avoid complications of time-dependent issues. The aim of this paper is to suggest a possible strategy for the management of patients with Hirschsprung MESHD ( HSCR MESHD) during this dramatic Covid-19 pandemic considering.MATERIALS AND METHODS - A systematic literature search on PubMed and Embase of all available literature addressing “Hirschsprung”, “preoperative enterocolitis MESHD”, “preoperative mortality”, “complications”, and “timing” in all possible combination has been performed limiting documents to the last 10 years and excluding non-English papers.RESULTS – Systematic review assessed 170 papers and focused on 10 full-text papers addressing the same issues as above. The incidence of preoperative HAEC proved to be as high as 34% with a mortality between 2.4% and 8%. Age TRANS at surgery varied in literature reports but recent evidences suggested that patients should be operated around 3 months of age TRANS after effective bowel decompression. Rectal irrigations should not be continued over 2 to 4 months to avoid nutritional issues and subsequent possible increase of surgical complications.CONCLUSIONS – Based on available literature, contingent shortage of health resources and necessity to avoid hospital overcrowding during this pandemic, we suggest as follows: 1) surgery should be delayed for healthy neonates up to 3 months of age TRANS, and a diverting enterostomy consider for those with ultralong HSCR MESHD, unwell or with ineffective nursing; 2) surgery can be delayed but rectal irrigations cannot be maintained indefinitely (ideally within 2 to 4 months at maximum); 3) Surgery could be postponed in older patients, provided previous bouts of HAEC are excluded. This chosen behaviour of our Center for Digestive Diseases aims at avoiding risk of complication and serve the best for our patients in this delicate setting of Covid-19 pandemic.

    Computerized tomography scan findings of a patient with severe enterocolitis HP enterocolitis MESHD associated with the coronavirus disease MESHD 2019: a case report

    Authors: Katsunari Takifuji; Hiroshi Terasawa; Masami Oka; Masaki Sahara; Tomoko Hara; Hidekazu Itoh

    doi:10.21203/ Date: 2020-04-03 Source: ResearchSquare

    Background: Currently, there is no available study about the occurrence of enterocolitis HP enterocolitis MESHD associated with the coronavirus disease MESHD 2019 (COVID-19) among adults TRANS. Case presentation: A 56-year-old man had lower abdominal pain HP abdominal pain MESHD, distension, diarrhea, and bloody HP diarrhea, and bloody MESHD stool. Moreover, the patient presented with fever HP fever MESHD and general fatigue MESHD fatigue HP. Laboratory examination did not reveal leukocytosis HP leukocytosis MESHD nor neutrophilia HP. However, the patient’s C-reactive protein level increased to 4.9 (normal range: 0.0–0.3) mg/dL. Both sputum and stool cultures had normal results. However, abdominal computed tomography (CT) scan revealed wall thickness mainly in the submucosal layer of the left part of the large intestine. Thus, real-time polymerase chain reaction test of throat swabs was performed for the diagnosis of COVID-19, and positive results were obtained. Conclusions: We report the first case of enterocolitis HP enterocolitis MESHD correlated to COVID-19, and the patient had positive abdominal CT scan findings. This imaging modality could be effective for the diagnosis of enterocolitis HP enterocolitis MESHD associated with COVID-19.

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MeSH Disease
Human Phenotype

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