Corpus overview


MeSH Disease

Human Phenotype


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    Acute eosinophilic pneumonia MESHD pneumonia HP associated with elevated NKT cell response in COVID-19 patients

    Authors: Dong-Min Kim; Jun-Won Seo; Yuri Kim; Uni Park; Na-Young Ha; Hyoree Park; Na Ra Yun; Da Young Kim; Sung Ho Yoon; Yong Sub Na; Do Sik Moon; Sung-Chul Lim; Choon-Mee Kim; Kyeongseok Jeon; Jun-Gu Kang; Yeon-Sook Kim; Nam-Hyuk Cho

    doi:10.21203/ Date: 2020-04-17 Source: ResearchSquare

    Coronavirus disease MESHD 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2)1 and often results in fatal pneumonia HP pneumonia MESHD.2,3 Despite the worldwide effect of the COVID-19 pandemic, the underlying mechanisms of the fatal viral pneumonia HP pneumonia MESHD remain elusive. Here, we investigated respiratory specimens, including broncholoalveolar lavage fluids (BALFs) and bloods SERO collected from three confirmed cases TRANS of COVID-19 patients with varying degrees of disease severity. Surprisingly, over 35% of cells from BALFs obtained from two pneumonic patients was comprised of eosinophils, while 20% was comprised of lymphocytes. Cytological analysis of sputa and tracheal aspirates from all three patients also revealed that more than 90% of total cells were eosinophils. Infiltration of CD16+/CD24+ polymorphonuclear cells into lungs, together with elevated NKT cells in BALFs and peripheral blood SERO samples, in patients with severe pneumonia HP pneumonia MESHD was confirmed by flow cytometry. Moreover, rapid and profound IgE responses against the N protein of SARS-CoV-2 was only detected in plasma SERO from a patient suffering from more severe and prolonged pneumonia MESHD pneumonia HP. A significant reduction in oxygen demand with improved chest imaging was observed in two severe COVID-19 patients after treatment with a steroid, methylprednisolone. The present study provides evidence that acute eosinophilic MESHD pneumonia4 is associated with COVID-19. 

    Lymphopenia HP Lymphopenia MESHD acted as an adverse factor for severity in patients with COVID-19: a single-centered, retrospective study

    Authors: Jiheng Liu; Heng Li; Ming Luo; Jiyang Liu; Lingzhen Wu; Xianfeng Lin; Ruijuan Li; Zhihua Wang; Haiying Zhong; Wenli Zheng; Yan Zhou; Dixuan Jiang; Xin Tan; Zhiguo Zhou; Hongling Peng; Guangsen Zhang

    doi:10.21203/ Date: 2020-04-14 Source: ResearchSquare

    Purpose: The outbreak of SARS-CoV-2 began in December and rapidly caused a pandemic. To investigate the significance of lymphopenia HP lymphopenia MESHD for the severity of the disease, this study was performed.Methods: 115 patients confirmed COVID-19 from a tertiary hospital in Changsha, China were enrolled. The clinical, laboratory, treatment and outcome data were collected and compared between patients with lymphopenia HP lymphopenia MESHD or not.Results: The median age TRANS was 42 years (1-75). 54 patients (47.0%) of the patients had lymphopenia HP lymphopenia MESHD on admission. In the group of lymphopenia HP lymphopenia MESHD, more patients had hypertension HP hypertension MESHD (30.8% vs 10.0%, P=0.006) and coronary heart disease MESHD (3.6% vs 0%, P=0.029) and more patients with leucopenia (48.1% vs 14.8%, P<0.001) and eosinophilia HP eosinophilia MESHD (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia HP Lymphopenia MESHD was also correlated with severity grades of pneumonia HP pneumonia MESHD (P<0.001) and C-reactive protein (CRP) level (P=0.0014). Lymphopenia HP Lymphopenia MESHD was associated with a prolonged duration of hospitalization (17.0 days vs 14.0 days, P=0.002). Moreover, the recovery of lymphocyte appeared the earliest before CRP and chest radiographs in severe cases, suggesting its predictive value for disease improvement. Conclusion: Our results showed the clinical significance of lymphopenia HP lymphopenia MESHD for predicting the severity of COVID-19 and the recovery of the disease, emphasizing the need to monitor the lymphocyte count dynamically.

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MeSH Disease
Human Phenotype

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