Neurological manifestations have been reported in adults TRANS with COVID-19. In children TRANS with COVID-19, data on neurological symptoms are scarce. A 4-year-old girl was assisted at home for prolonged afebrile seizures MESHD seizures HP. She was unresponsive, with a conjugate eye right deviation lasting > 20 minutes. Intravenous midazolam was administered. Before arrival in our Emergency MESHD Department, EMS providers excluded risk factors for COVID-19, such as fever MESHD fever HP, respiratory symptoms, other signs of viral infections MESHD, or recent contacts with suspected COVID-19 cases. Upon her arrival, seizures MESHD seizures HP had resolved, GCS was 12. Temperature was 36,6°C. Chest was clear (SatO2 100%). Blood SERO tests did not show signs of infection MESHD. We collected a nasopharyngeal swab, which tested positive for SARS-CoV-2. The patient rapidly recovered her neurological function. A pediatric neurological examination and video-EEG recording produced a possible diagnosis of self-limited focal epilepsy MESHD, with temporo-occipital spikes. Family history revealed her father had occasional seizures MESHD seizures HP during fever MESHD fever HP episodes, at 14 and 21 years. The child TRANS was discharged home, scheduling further neurological investigations once the swab was negative. Our case emphasizes that keeping a high suspicion for SARS-CoV-2 infection MESHD is pivotal in hot spots, regardless of the absence of typical COVID-19 symptoms. As for the seizures MESHD seizures HP episode, we know infections MESHD and fever MESHD fever HP are leading seizure MESHD seizure HP precipitating factors in children TRANS. To our knowledge, this is the first case of focal status epilepticus MESHD status epilepticus HP in new onset focal self-limited epilepsy MESHD in an afebrile child TRANS with SARS-CoV-2. We speculate that SARS-CoV-2 infection MESHD may have triggered the onset of self-limited focal epilepsy MESHD in our patient.