Corpus overview


MeSH Disease

Human Phenotype


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    COVID-19 and Epilepsy MESHD

    Authors: Amira Sidig; Radi Tofaha Alhusseini; Khabab Abbasher; Mohamed Elsayed; Hussien Abbasher; Mohammed Abbasher; Sufian Khalid M. N; Khalid Hajnoor; Mohammed Malekaldar; Abbasher Hussien; Omer Eladil A. Hamid; Mutaz F. Digna

    doi:10.21203/ Date: 2020-07-26 Source: ResearchSquare

    Introduction: COVID-19 caused by SARS-CoV-2 acquired via respiratory droplets. It can present with many systemic disorders, includingA 45-year-old Sudanese male TRANS known to have well-controlled generalized tonic-clonic epilepsy MESHD, He presented to the Accident and Emergency MESHD (A&E) department complaining of refractory status epilepticus MESHD status epilepticus HP. Despite immediate initial stabilization, the seizure MESHD seizure HP attacks were still refractory to intravenous loading doses of antiepileptic drugs AEDs. Hence the patient was intubated and mechanically ventilated. Brain MRI and EEG were normal. The chest X-ray was normal. The screening of COVID-19 was positive. Epilepsy MESHD is one of the most common neurological disorders. Since the beginning of the Coronavirus outbreak in December 2019, no available research data is suggesting that the patients with epilepsy MESHD are at more risk than others. As no available data relating epilepsy MESHD to severe COVID-19 infection MESHD (6). Moreover, no data studied COVID-19 and the sudden unexpected death MESHD among epileptic patients (SUDEP).Conclusion: This case might report the effect of SARS-CoV-2 on provoking the refractory seizures MESHD seizures HP in a previously well-controlled patient with epilepsy MESHD. More researches are needed to explain the relation between COVID and seizure MESHD seizure HP threshold.

    Self-limited focal epilepsy MESHD in a young child TRANS with SARS-CoV-2: serendipity or causal association?

    Authors: Davide Silvagni; Pietro Soloni; Francesca Darra; Paolo Biban

    doi:10.21203/ Date: 2020-05-21 Source: ResearchSquare

    Neurological manifestations have been reported in adults TRANS with COVID-19. In children TRANS with COVID-19, data on neurological symptoms are scarce. A 4-year-old girl was assisted at home for prolonged afebrile seizures MESHD seizures HP. She was unresponsive, with a conjugate eye right deviation lasting > 20 minutes. Intravenous midazolam was administered. Before arrival in our Emergency MESHD Department, EMS providers excluded risk factors for COVID-19, such as fever MESHD fever HP, respiratory symptoms, other signs of viral infections MESHD, or recent contacts with suspected COVID-19 cases. Upon her arrival, seizures MESHD seizures HP had resolved, GCS was 12. Temperature was 36,6°C. Chest was clear (SatO2 100%). Blood SERO tests did not show signs of infection MESHD. We collected a nasopharyngeal swab, which tested positive for SARS-CoV-2. The patient rapidly recovered her neurological function. A pediatric neurological examination and video-EEG recording produced a possible diagnosis of self-limited focal epilepsy MESHD, with temporo-occipital spikes. Family history revealed her father had occasional seizures MESHD seizures HP during fever MESHD fever HP episodes, at 14 and 21 years. The child TRANS was discharged home, scheduling further neurological investigations once the swab was negative. Our case emphasizes that keeping a high suspicion for SARS-CoV-2 infection MESHD is pivotal in hot spots, regardless of the absence of typical COVID-19 symptoms. As for the seizures MESHD seizures HP episode, we know infections MESHD and fever MESHD fever HP are leading seizure MESHD seizure HP precipitating factors in children TRANS. To our knowledge, this is the first case of focal status epilepticus MESHD status epilepticus HP in new onset focal self-limited epilepsy MESHD in an afebrile child TRANS with SARS-CoV-2. We speculate that SARS-CoV-2 infection MESHD may have triggered the onset of self-limited focal epilepsy MESHD in our patient.

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MeSH Disease
Human Phenotype

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