Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission TRANS and fetal demise from an asymptomatic TRANS mother

    Authors: Prajakta Shende; Pradip Gaikwad; Manisha Gandhewar; Pawankumar Ukey; Anshul Bhide; Vainav Patel; Sharad Bhagat; Vikrant Bhor; Smita Mahale; Rahul Gajbhiye; Deepak Modi; Carlos Meza Carvajalino; Luis Carlos Villamil; Efrain Benavides Ortiz; Michael P Lunn; Cristina M. Tato; Kevin K. Leung; Bryan Greenhouse; James A. Wells; Ainara Coduras Erdozain; Carmen Martinez Cilleros; Jose Loureiro Amigo; Francisco Epelde; Carlos Lumbreras Bermejo; Juan Miguel Anton Santos

    doi:10.1101/2020.08.18.20177121 Date: 2020-08-21 Source: medRxiv

    Coronaviruses infect MESHD the respiratory tract and are known to survive in these tissues during the clinical course of infection. However, how long can SARS-CoV-2 survive in the tissues is hitherto unknown. Herein, we report a case where the virus is detected in the first trimester placental cytotrophoblast and syncytiotrophoblasts five weeks after the asymptomatic TRANS mother cleared the virus from the respiratory tract. This first trimester placental infection MESHD was vertically transmitted as the virus was detected in the amniotic fluid and fetal membranes. This congenitally acquired SARS-CoV-2 infection MESHD was associated with hydrops and fetal demise. This is the first study providing concrete evidences towards persistent tissue infection of SARS-CoV-2 MESHD, its congenital transmission TRANS in early pregnancy leading to intrauterine fetal death MESHD.

    Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait

    Authors: Amal Ayed; Alia Embaireeg; Asmaa Benawadth; Wadha Al-Fouzan; Majeda Hammoud; Monif Alhathal; Abeer Alzaydai; Mariam Ayed

    doi:10.1101/2020.07.10.20150623 Date: 2020-07-14 Source: medRxiv

    Background: In late December of 2019, a novel coronavirus (SARS-CoV-2) was identified in the Chinese city Wuhan among a cluster of pneumonia HP pneumonia MESHD patients. While it is known that pregnant women have reduced immunity and they are at risk for COVID-19 infection during the current pandemic, it is not clear if the disease manifestation would be different in pregnant women from non-pregnant women. Objectives: To describe the maternal and neonatal clinical features as well as outcome of pregnancies complicated with SARS-CoV-2 infection MESHD. Methods: In this retrospective national-based study, we analyzed the medical records of all SARS-CoV-2 positive pregnant patients and their neonates who were admitted to New-Jahra Hospital, Kuwait, between March 15th 2020 and May 31st 2020. The outcomes of pregnancies were assessed until the end date of follow-up (June 15th 2020). Results: A total of 185 pregnant women were enrolled with a median age TRANS of 31 years (interquartile range, IQR: 27.5-34), and median gestational age TRANS at diagnosis was 29 weeks (IQR: 18-34). The majority (88%) of the patients had mild symptoms, with fever HP fever MESHD (58%) being the most common presenting symptom followed by cough HP (50.6%). During the study period, 141 (76.2%) patients continued their pregnancy, 3 (1.6%) had a miscarriage, 1 (0.5%) had intrauterine fetal death MESHD and only 2 (1.1%) patients developed severe pneumonia HP pneumonia MESHD and required intensive care. Most of the neonates were asymptomatic TRANS, and only 2 (5%) of them tested positive on day 5 by nasopharyngeal swab testing. Conclusion: Pregnant women do not appear to be at higher risk to the COVID-19 than the general population. The clinical features of pregnant women with SARS-CoV-2 infection MESHD were similar to those of the general population having SARS-CoV-2 infection MESHD. Favorable maternal and neonatal outcomes reinforce the existing evidence and may guide healthcare professionals in the management of pregnancies complicated with SARS-CoV-2 infection MESHD.

    Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

    Authors: Jeong Yee; Woorim Kim; Ji Min Han; Ha Young Yoon; Nari Lee; Kyung Eun Lee; Hye Sun Gwak

    doi:10.21203/ Date: 2020-05-18 Source: ResearchSquare

    This systematic review and meta-analysis aimed to evaluate the impact of COVID-19 on pregnant women. We searched for qualified studies in PubMed, Embase, and Web of Science. The clinical characteristics of pregnant women with COVID-19 and their infants were reported as means and proportions with 95% confidence interval (CI). Nine studies involving with 93 pregnant women with COVID-19 and 103 infants were included in the meta-analysis. Pregnant women with COVID-19 have relatively mild symptoms. However, abnormal proportions of laboratory parameters were similar or even increased, compared to general population. Around 30% of pregnant women with COVID-19 experienced preterm delivery, whereas the mean birth weight was 3214.7g. Fetal death MESHD, severe neonatal asphyxia HP neonatal asphyxia MESHD, and detection of SARS-CoV-2 were observed in about 2%, whereas no neonatal death was found. In conclusion, the current review will serve as an ideal basis for future considerations in the treatment and management of COVID-19 in pregnant women.

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MeSH Disease
Human Phenotype

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