Corpus overview


MeSH Disease

Human Phenotype

Fetal distress (4)

Fever (3)

Cough (3)

Diarrhea (2)

Dyspnea (2)


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    SARS-CoV-2 placental infection MESHD and inflammation MESHD leading to fetal distress MESHD fetal distress HP and neonatal multi-organ failure in an asymptomatic TRANS woman

    Authors: Sam Schoenmakers; Pauline Snijder; Rob Verdijk; Thijs Kuiken; Sylvia Kamphuis; Laurens Koopman; Thomas Krasemann; Melek Rousian; Michelle Broekhuizen; Eric Steegers; Marion Koopmans; Pieter Fraaij; Irwin Reiss

    doi:10.1101/2020.06.08.20110437 Date: 2020-06-09 Source: medRxiv

    Abstract Introduction In general SARS-CoV-2- infection MESHD during pregnancy is not considered to be an increased risk for severe maternal outcomes, but has been associated with an increased risk for fetal distress MESHD fetal distress HP. So far, there is no direct evidence of intrauterine vertical transmission TRANS and the mechanisms leading to the adverse outcomes are not well understood Results An asymptomatic TRANS pregnant woman with preterm fetal distress MESHD fetal distress HP during the COVID19 pandemic was included. We obtained multiple maternal, placental and neonatal swabs, which showed a median viral load in maternal blood SERO, urine, oropharynx, fornix posterior over a period of 6 days was 5.0 log copies /mL. The maternal side of the placenta had a viral load of 4.42 log copies /mL, while the fetal side had 7.15 log copies /mL. Maternal breast milk, feces and all neonatal samples tested negative. Serology of immunoglobulins against SARS-CoV-2 was tested positive in maternal blood SERO, but negative in umbilical cord and neonatal blood SERO. Pathological examination of the placenta included immunohistochemical investigation against SARS-CoV-2 antigen expression in combination with SARS-CoV-2 RNA in situ hybridization and transmission TRANS electron microscopy. It showed the presence of SARS-CoV-2 particles with generalized inflammation MESHD characterized by histiocytic intervillositis with diffuse perivillous fibrin depositions with damage to the syncytiotrophoblasts. Discussion Placental infection MESHD by SARS-CoV-2 lead to fibrin depositions hampering fetal-maternal gas exchange most likely resulted in fetal distress MESHD fetal distress HP necessitating a premature emergency MESHD caesarean section. Postpartum, the neonate showed a clinical presentation resembling a pediatric inflammatory multisystem syndrome MESHD including coronary artery ectasia, most likely associated with SARS-CoV-2 (PIMS-TS) for which admittance and care on the Neonatal Intensive Care unit (NICU) was required, despite being negative for SARS-CoV-2. This highlights the need for awareness of adverse fetal and neonatal outcomes during the current COVID-19 pandemic, especially considering that the majority of pregnant women appear asymptomatic TRANS.

    Clinical Manifestation and Maternal Complications and Neonatal outcomes in Pregnant Women with COVID 19: An Update a Systematic Review and Meta-analysis

    Authors: Marzieh Soheili; Ghobad Moradi; Hamid Reza Baradaran; Maryam Soheili; Yousef Moradi

    doi:10.21203/ Date: 2020-05-07 Source: ResearchSquare

    Background Existing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with coronavirus infection MESHD. outbreaks suggest that pregnant women and their fetuses are particularly susceptible to poor outcomes. However, there is little known about pregnancy related complications and co-morbidity in this group of women. Therefore, this, systematic review and meta-analysis performed in order to find out whether COVID-19 may cause different manifestations and outcomes in antepartum and postpartum period or not.Methods We searched databases, including Medline (PubMed), Embase, Scopus, Web of sciences, Cochrane library, Ovid and CINHAL to retrieve all articles reporting the prevalence SERO of maternal and neonatal complications, in addition clinical manifestations, in pregnant women with COVID 19 that published with English language from January to April 2020. Results 11 studies with total 177 pregnant women included in this systematic review.Results show that the pooled prevalence SERO of neonatal mortality, lower birth weight MESHD, stillbirth MESHD, premature birth MESHD premature birth HP, and intrauterine fetal distress MESHD fetal distress HP in women with COVID 19 were 4% (95% Cl: 1 - 9%), 21% (95% Cl: 11 – 31%), 2% (95% Cl: 1 - 6%), 28% (95% Cl: 12 - 44%), and 15% (95% Cl: 4 - 26%); respectively. Also the pooled prevalence SERO of fever MESHD fever HP, cough MESHD cough HP, diarrhea MESHD diarrhea HP and dyspnea MESHD dyspnea HP were 56% (95% Cl: 30 - 83%), 30% (95% Cl: 21 - 39%), 9% (95% Cl: 2 - 16%), and 3% (95% Cl: 1 - 6%) in the pregnant women with COVID-19.Conclusion According to this systematic review and meta-analysis, the pregnant women with COVID-19 with or without pneumonia MESHD pneumonia HP, are at a higher risk of pre-eclampsia MESHD eclampsia HP, preterm birth, miscarriage and cesarean delivery. Furthermore, the risk of LBW and intrauterine fetal distress MESHD fetal distress HP seems increased in neonates.

    Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

    Authors: Yi-jie Gao; Lei Ye; Jia-shuo Zhang; Yang-xue Yin; Min Liu; Hong-biao Yu; Rong Zhou

    doi:10.21203/ Date: 2020-05-05 Source: ResearchSquare

    Background: COVID-19 outbreak in Wuhan, China recently. It quickly spread throughout worldwide. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19.Methods: PubMed、Web of Science、EMBASE、MEDLINE were searched from January 1, 2020 to April 16, 2020. Case review of pregnant women infected with COVID-19 were included. Two reviewers screened 366 literatures and 14 studies included, four reviewers independently extracted the features of the literatures. We used random-effects model to analyze incidence (P) and 95% confidence interval (95%CI). Heterogeneity was assessed using the I2 statistic.Results: The meta- analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95%CI, 0.49~0.93), cesarean section (65%; 95%CI, 0.42~0.87), fever MESHD fever HP (51%; 95%CI, 0.35~0.67), lymphopenia MESHD lymphopenia HP (49%; 95%CI, 0.29~0.70), coexisting disorders (33%; 95%CI, 0.21~0.44), cough MESHD cough HP (31%; 95%CI, 0.23~0.39), fetal distress MESHD fetal distress HP (29%; 95%CI, 0.08~0.49), preterm labor (23%; 95%CI, 0.14~0.32), severe case or death MESHD (12%; 95%CI, 0.03~0.20). The subgroup analysis showed compared with nonpregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever MESHD fever HP (pregnant women group, 51%; nonpregnant patients group, 91%; P<0.00001) and cough MESHD cough HP (pregnant women group, 31%; nonpregnant patients group, 67%; P<0.0001). Conclusions: The incidence of fever MESHD fever HP, cough MESHD cough HP and positive CT findings in pregnant women with COVID-19 is less than that in the general population, preterm labor is the opposite. There is no evidence that COVID-19 can propagate vertically for the time being. 

    Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission TRANS of SARS-CoV-2 in women with COVID-19: A systematic review

    Authors: Rahul Gajbhiye; Deepak Modi; Smita Mahale

    doi:10.1101/2020.04.11.20062356 Date: 2020-04-15 Source: medRxiv

    Abstract Objective: The aim of this systematic review was to examine published and preprint reports for maternal and fetal outcomes in pregnant women with COVID-19 and also assess the incidence of maternal-fetal transmission TRANS of SARS CO-V-2 infection MESHD. Design : Systematic review Data sources:We searched PUMBED. Medline, Embase, MedRxiv and bioRxiv databases upto 31st March 2020 utilizing combinations of word variants for " coronavirus " or " COVID-19 " or " severe acute respiratory syndrome MESHD " or " SARS-COV-2 " and " pregnancy " . We also included data from preprint articles. Study selection : Original case reports and case series on pregnant women with a confirmed diagnosis of SARS-CoV-2 infection MESHD. Data extraction : We included 23 studies [China (20), USA (01), Republic of Korea (01) and Honduras, Central America (01) reporting the information on 172 pregnant women and 162 neonates. The primary outcome measures were maternal health characteristics and adverse pregnancy outcomes, neonatal outcomes and SARS-CoV-2 infection MESHD in neonates was extracted. Treatments given to pregnant women with COVID-19 were also recorded. Results: Out of 172 women affected by COVID-19 in pregnancy, 160 women had delivered 162 newborns (2 set of twins, 12 ongoing pregnancies). In pregnant women with COVID-19, the most common symptoms were fever MESHD fever HP (54%), cough MESHD cough HP (35%), myalgia MESHD myalgia HP (17%), dyspnea MESHD dyspnea HP (12%) and diarrhea MESHD diarrhea HP (4%). Pneumonia MESHD Pneumonia HP was diagnosed by CT scan imaging in 100 % of COVID-19 pregnant women. Pregnancy complications MESHD included delivery by cesarean section (89%), preterm labor (21%), fetal distress MESHD fetal distress HP (9%) and premature rupture of membranes HP rupture MESHD of membranes (8%). The most common co-morbidities associated with pregnant women with COVID-19 were diabetes (11%), hypertensive disorders (9%), placental disorders (5%), co- infections MESHD (6%), scarred HP uterus (5%), hypothyroidism MESHD hypothyroidism HP (5%) and anemia MESHD anemia HP (4%). Amongst the neonates of COVID-19 mothers, preterm birth (23%), respiratory distress HP syndrome MESHD (14%), pneumonia MESHD pneumonia HP (14%) low birth weight MESHD (11%), small for gestational age HP age TRANS (3%) were reported. There was one still birth and one neonatal death MESHD reported. Vertical transmission TRANS rate of SARS-CoV-2 is estimated to be 11%. Conclusion In pregnant women with COVID-19, diabetes and hypertensive disorders are common co-morbidities and there is a risk of preterm delivery. Amongst the neonates born to mothers with COVID-19, respiratory distress HP syndrome MESHD and pneumonia MESHD pneumonia HP are common occurrence. There is an evidence of vertical transmission TRANS of SARS-CoV-2 infection MESHD in women with COVID-19.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

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