Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Ocular surface manifestation of COVID-19 and tear film analysis

    Authors: Alessandro Meduri; Giovanni William Oliverio; Giuseppe Mancuso; Angela Giuffrida; Claudio Guarneri; Emmanuele Venanzi Rullo; Giuseppe Nunnari; Pasquale Aragona

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    Purpose: To evaluate the ocular manifestation in patients hospitalized with coronavirus disease MESHD 2019 (COVID-19) and to search for the presence of severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) in tears.Methods: This study was conducted in 29 hospitalized patients who were admitted to the COVID center at the Policlinic Hospital of the University of Messina, Italy.All patients underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire, anterior segment, and the ocular surface examination of both eyes using a portable slit lamp.The Schirmer I test was performed, and the filter paper strip was used to search for the presence of SARS-CoV-2 on the ocular surface by real-time quantitative polymerase chain reaction (RT-qPCR).Results: A total of 10 patients reported ocular symptoms; in particular, four reported eye burning MESHD, three reported foreign body MESHD sensation, and three reported tearing. Moreover, seven patients presented conjunctival hyperemia HP hyperemia MESHD and/or chemosis HP, eleven patients presented blepharitis MESHD blepharitis HP signs such as lid margin hyperemia MESHD and/or telangiectasia HP, crusted eyelashes, and meibomian orifices alterations. Tear analysis did not reveal the presence of SARS-CoV-2.Conclusion: Ocular symptoms are common in patients with COVID-19; although, tear analysis did not reveal the presence of SARS-CoV-2.

    Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study

    Authors: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun

    doi:10.1101/2020.03.12.20034678 Date: 2020-03-16 Source: medRxiv

    Objective: The novel coronavirus disease MESHD (COVID-19) was first reported in Wuhan, China in December 2019 and is now pandemic all over the world. Previous study has reported several COVID-19 cases with conjunctivitis MESHD conjunctivitis HP. However, the complete profiling of COVID-19 related ocular symptoms and diseases MESHD are still missing. We aim to investigate the ocular manifestations and clinical characteristics of COVID-19 patients. Methods: A total of five hundred and thirty-four patients were recruited at Mobile Cabin Hospital and Tongji Hospital. We collected information on demographic characteristics, exposure history, ocular symptoms, systemic concomitant symptoms, eye drop medication, eye protections, radiologic findings, and SARS-CoV-2 detection in nasopharyngeal swabs by RT-PCR from questionnaires and electronic medical records. Results: The median age TRANS of patients was 40 and 50 years at Mobile Cabin Hospital and Tongji Hospital, respectively. Of 534 COVID-19 patients, 25 patients (4.68%) presented with conjunctival congestion and 3 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 4.9 {+/-} 2.6 days (mean [SD]), ranging from 2 to 10 days. Dry eye (112, 20.97%), blurred vision HP (68, 12.73%), and foreign body MESHD sensation (63, 11.80%) ranked as the top three COVID-19 related ocular symptoms. Notably, a total of 332 COVID-19 patients (62%) had a hand-eye contact history. We also found that some COVID-19 patients had a history of eye disease MESHD, including conjunctivitis MESHD conjunctivitis HP (33, 6.18%), dry eye (24, 4.49%), keratitis MESHD keratitis HP (14, 2.62%), cataract MESHD cataract HP (9, 1.69%), and diabetic retinopathy MESHD retinopathy HP (5, 0.94%). In consistent with previous studies, the most common clinical symptoms were fever MESHD fever HP, cough MESHD cough HP, and fatigue MESHD fatigue HP. Patients, 60.5% in Mobile Cabin Hospital and 67.5% in Tongji Hospital, respectively were confirmed with positive SARS-CoV-2 detection. Conclusions: Conjunctival congestion was one of the COVID-19 related ocular symptoms, which may have clinical diagnostic significance. It is essential to provide eye-care equipment and strengthen education on eye protection, as dirty hand-eye contact might be a high risk factor of COVID-19. Further detailed and comprehensive ophthalmological guidance is needed for COVID-19 control.

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MeSH Disease
Human Phenotype

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