Corpus overview


MeSH Disease

Human Phenotype


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    The Mechanism of Prevention and Treatment of Maxing Shigan Decoction on Pulmonary Heart Injury MESHD Caused by Novel Coronavirus Pneumonia MESHD Pneumonia HP

    Authors: Dongling Liu; Jing Su; Wenqian Hou; Weiyu Ren; Yijun Zheng; Yanmei Ning; Xiaojie Jin; Yongqi Liu

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    Background To explore the mechanism of Maxing Shigan Decoction in the treatment of myocardial injury and lung MESHD injury through network pharmacology and molecular docking technology.Methods In Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM) and the Comparative Toxicogenomics Database, National Center for Biotechnology Information database, Online Mendelian Inheritance in Man database, the compounds and targets of each drug in Maxing Shigan Decoction and the targets of “acute lung intervention” and “myocardial injury” diseases MESHD were searched. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed by the DAVID database. GOLD 5.1 was used for molecular docking.Results Maxing Shigan Decoction includes 327 compounds and 2722 targets, including 30 key targets. 2125 items were obtained by GO enrichment analysis, including 2047 items of Biological Process, 28 items of Cell Composition and 50 items of Molecular Function. The KEGG pathway was enriched to obtain 149 pathways. The results of molecular docking showed that Gancaonin H and Licorice Glycoside E were well combined with Angiotensin-Converting Enzyme 2-A (ACE2-A) and Angiotensin-Converting Enzyme 2-B (ACE2-B), respectively, and Licorice was well combined with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Interleukin 6 (IL-6). Supraene is an active compound of Ephedra. It has good binding with ACE2-A, ACE2-B, GM-CSF and IL-6, respectively. (6Z, 10E, 14E, 18E)-2, 6, 10, 15, 19, 23- hexamethyletracosa-2, 6, 10, 14, 18, 22- hexaene are the active compounds of Almond, which are well combined with ACE2-A, ACE2-B, GM-CSF and IL-6.Conclusion Maxing Shigan Decoction may act on ACE2, GM-CSF and IL-6 targets through the active compounds Supraene of Ephedra, and Almond (6Z, 10E, 14E, 18E)-2, 6, 10, 15, 19, 23-hexamethyletracosa-2, 6, 10, 14, 18, 22-hexaene. Gancainin H and licorice Glycide E are the active compounds of Licorice, act on A and B sites of ACE2 respectively, and Glycyrin acts on GM-CSF and IL-6 targets, coordinating multiple signal pathways to play anti-inflammatory and antiviral roles to prevent and treat lung and heart injury MESHD caused by Severe Acute Respiratory Syndrome MESHD Coronavirus 2 (SARS-CoV-2).

    Clinical characteristics and manifestations in older patients with COVID-19

    Authors: Chenchen Wei; Ya Liu; Yapeng Liu; Kai Zhang; Dezhen Su; Ming Zhong; Xiao Meng

    doi:10.21203/ Date: 2020-05-11 Source: ResearchSquare

    Background: To investigate the clinical characteristics and manifestations of older patients with coronavirus disease MESHD 2019 (COVID-19).Methods: In this retrospective study, 566 patients with confirmed COVID-19 were enrolled and the clinical characteristics, laboratory findings, complications and outcome data were collected and analyzed.Results: Among the 566 patients (median age TRANS, 61.5 years) with COVID-19, 267 (47.2%) patients were male TRANS and 307 (54.2%) were elderly TRANS. Compared with younger patients, older patients had more underlying comorbidities and laboratory abnormalities. A higher rate of acute respiratory distress HP syndrome MESHD (ARDS), acute cardiac injury and heart MESHD failure was observed in the older group as compared with younger and middle- aged groups TRANS, particularly those oldest-old patients (>75 years) had more multi-organ damage. Older patients with COVID-19 were more likely to suffer from acute cardiac injury in cases with preexistenting cardiovascular diseases MESHD, while there was no difference among the three groups when patients had no history of cardiovascular diseases MESHD. Older patients present more severe with the mortality of 18.6%, which was higher than that in younger and middle- aged TRANS patients (P<0.05). Multivariable analysis showed that age TRANS, lymphopenia MESHD lymphopenia HP, ARDS, acute cardiac injury, heart MESHD failure and skeletal muscle injury were associated with death MESHD in older patients, while glucocorticoids may be harmful.Conclusions: Older patients, especially the oldest-old patients were more likely to exhibit significant systemic inflammation MESHD, pulmonary and extrapulmonary organ damage and a higher mortality. Advanced age TRANS, lymphopenia MESHD lymphopenia HP, ARDS, acute cardiac injury, heart MESHD failure and skeletal muscle injury were independent predictors of death MESHD in older patients with COVID19 and glucocorticoids should be carefully administered in older patients.

    Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study

    Authors: Shiqiang Xiong; Lin Liu; Feng Lin; Jinhu Shi; Lei Han; Huijian Liu; Lewei He; Qijun Jiang; Zeyang Wang; Wenbo Fu; Zhigang Li; Qing Lu; Zhinan Chen; Shifang Ding

    doi:10.21203/ Date: 2020-05-01 Source: ResearchSquare

    Background A cluster of acute respiratory illness, now known as Corona Virus Disease MESHD 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged TRANS population with cardiovascular diseases MESHD are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases MESHD have a high prevalence SERO in the middle- aged TRANS and elderly TRANS population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need.Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs MESHD, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases. Results Of 116 hospitalized patients with COVID-19, the median age TRANS was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female TRANS. Hypertension MESHD Hypertension HP (45 [38.8%]), diabetes (19 [16.4%]), and coronary heart disease MESHD (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever MESHD fever HP [99 (85.3%)], dry cough MESHD cough HP (61 [52.6%]), fatigue MESHD fatigue HP (60 [51.7%]), dyspnea MESHD dyspnea HP (52 [44.8%]), anorexia MESHD anorexia HP (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia MESHD Lymphopenia HP (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia MESHD Hypokalemia HP occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury (19 [34.5%] vs 4 [6.6%]), acute heart failure MESHD (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence SERO of new onset hypertension MESHD hypertension HP was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.Conclusions In this single-centered, retrospective, observational study, we found that the infection MESHD of SARS-CoV-2 was more likely to occur in middle and aged TRANS population with cardiovascular comorbidities. Cardiovascular complications, including new onset hypertension MESHD hypertension HP and heart injury MESHD were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease MESHD.

    Analysis of myocardial enzyme spectrum in 230 COVID-19 patients of Chongqing, China.

    Authors: Jiao CaiLing; Li Wen Fa; Xie YeHong; Miao JiaWei; Wu YunFang; Tan WanNing; Li Jing; Zhang JianRong

    doi:10.21203/ Date: 2020-04-19 Source: ResearchSquare

    Background A novel coronavirus disease MESHD COVID-19 outbreak caused pandemic in China and worldwide. In addition to pneumonia MESHD pneumonia HP, Cardiac failure is also a clinical outcome of coronavirus (COVID-19) patients and one of the leading causes for the death MESHD of COVID-19 patients. This study focused on a spectrum of cardiac enzymes to provide biomarkers for the severity of cardiomyopathy MESHD cardiomyopathy HP, and provide guidance of clinical treatment.Methods 230 coronavirus patients (182 mild and 48 severe cases) enrolled in Three Gorges Hospital of Chongqing University from January to March 2020 were analyzed for a spectrum of cardiac injury enzymes including α-hydroxybutyric dehydrogenase (αHBDH), lactic acid dehydrogenase (LDH), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB).Results The severe cases had significantly higher myocardial enzyme levels than mild cases, regardless of male TRANS and females TRANS. Males TRANS appeared to be more susceptible than females TRANS to COVID-19 induced heart injury MESHD, having higher CK and CK-MB in mild cases, and higher αHBDH and LDH levels in severe cases. Age TRANS is also a susceptible factor to COVID-19, but affected males TRANS were younger than females TRANS.Conclusions This study reveals that the heart is also a major target of COVID-19 infection MESHD, and myocardial enzyme spectrum assays could help the diagnosis, prognosis and guide the treatments to prevent heart failure MESHD in COVID-19 patients.

    Clinical Characteristics of Patients with 2019 Coronavirus disease MESHD in a non-Wuhan area of Hubei Province, China: a retrospective study

    Authors: Xin-Ying Zhao; Xuan-Xuan Xu; Hai-Sen Yin; Qin-Ming Hu; Tao Xiong; Yuan-Yan Tang; Ai-Ying Yang; Bao-Ping Yu; Zhi-Ping Huang

    doi:10.21203/ Date: 2020-02-27 Source: ResearchSquare

    Background: Since December, 2019, the 2019 Coronavirus disease MESHD (COVID-19) from Wuhan, China, has caused worldwide outbreak with more than 200,000 people infected and thousands of deaths MESHD. The clinical characteristics of COVID-19 patients in non-Wuhan areas of Hubei province have not been described. Methods: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. Results: Of the 91 patients diagnosed with COVID-19, 30 (33.0%) cases were severe and two (2.2%) patients died. The severe patients tended to be older (50.5 vs 42.0, P=0.049), and have more chronic disease MESHD (40% vs 14.75%, P=0.009), compared to mild group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR) positive on their first tests, while typical chest computed tomographic (CT) images were obtained for each patient. The most common complaints were cough MESHD cough HP (75, 82.4%), fever MESHD fever HP (59, 64.8%), fatigue MESHD fatigue HP (35, 38.5%), and diarrhea MESHD diarrhea HP (14, 15.4%). Non-respiratory injur y was identified by elevated levels of aspartate aminotransferase (18, 19.8%), creatinine (5, 5.5%) and creatine kinase (14, 15.4%) in laboratory tests. In sum, 28 (30.8%) cases suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. Conclusions: Overall, the mortality rate of patients in Jingzhou is lower than that of Wuhan. Importantly, we discovered liver, kidney, digestive tract and heart injury MESHD in COVID-19 cases besides respiratory problems. Combining Chest CT images with qPCR of throat swab samples would improve the accuracy of COVID-19 diagnose.

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MeSH Disease
Human Phenotype

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