Corpus overview


MeSH Disease

Human Phenotype


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    Proteinuria MESHD Proteinuria HP in COVID-19: prevalence SERO, characterization and prognostic role

    Authors: Justine Huart; Antoine Bouquegneau; Laurence Lutteri; Pauline Erpicum; Stéphanie Grosch; Guillaume Résimont; Patricia Wiesen; Christophe Bovy; Jean-Marie Krzesinski; Marie Thys; Bernard Lambermont; Benoit Misset; Hans Pottel; Christophe Mariat; Etienne Cavalier; Stéphane Burtey; François Jouret; Pierre Delanaye

    doi:10.21203/ Date: 2020-08-11 Source: ResearchSquare

    Background: Proteinuria MESHD Proteinuria HP has been commonly reported in patients with COVID-19, suggesting a renal involvement in this infection MESHD. However, only dipstick tests have been used thus far. Here, the quantification and characterization of proteinuria MESHD proteinuria HP and hematuria MESHD hematuria HP are investigated. Their potential association with mortality was assessed. Methods: This retrospective, observational and monocentric study includes 153 patients hospitalized with COVID-19 between March 28th and April 30th 2020, in whom total proteinuria MESHD proteinuria HP and urine α1-microglobulin (a marker of tubular injury) have been measured. Association with mortality was evaluated with a follow-up until May 7th 2020. Results: According to the Kidney Disease MESHD Improving Global Outcomes staging, 14% (n=21) had stage 1 proteinuria MESHD proteinuria HP (<150 mg/g of urine creatinine), 42% (n=64) had stage 2 (between 150 and 500 mg/g) and 44% (n=68) had stage 3 (over 500 mg/g). Urine α1-microglobulin concentration was higher than 10 or 15 mg/g in 94% and 89% of patients, respectively. After a median follow-up of 27 [14;30] days, the mortality rate reached 18%. Total proteinuria MESHD proteinuria HP and urine α1-microglobulin (as continuous and/or categorical variables) were associated with mortality in unadjusted and adjusted models. This association was even stronger in subgroups of patients with normal renal function or without urinary catheter. Conclusions: Proteinuria MESHD Proteinuria HP is frequent in patients with COVID-19. Its characterization suggests a tubular origin with increased urine α1-microglobulin. Tubular proteinuria MESHD proteinuria HP seems associated with mortality in COVID-19.

    Incidence, risk factors and mortality outcome in patients with acute kidney injury MESHD acute kidney injury HP in COVID-19: a single-center observational study

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Giacomo Mori; Riccardo Magistroni; Meschiari Marianna; Franceschini Erica; Marianna Menozzi; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Paolo Raggi; Massimo Girardis; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.24.20138230 Date: 2020-06-24 Source: medRxiv

    Background Acute kidney injury MESHD Acute kidney injury HP (AKI) is a recently recognized complication of coronavirus disease MESHD-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI in patients with documented COVID-19. Methods We reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. Results AKI was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI patients had a mean age TRANS of 74.7 {+/-} 9.9 years and higher serum SERO levels of the main marker of inflammation MESHD and organ involvement (lung, liver, hearth and liver) than non-AKI patients. AKI events were more frequent in subjects with severe lung comprise. Two peaks of AKI events coincided with in-hospital admission and death MESHD of the patients. Kidney injury was associate with a higher rate of urinary abnormalities including proteinuria MESHD proteinuria HP (0.448{+/-} 0.85 vs 0.18 {+/-} 0.29; P=<0.0001) and hematuria MESHD hematuria HP (P=0.032) compared to non-AKI patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI. Risk factors for kidney injury were age TRANS, male TRANS sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI was independently associated with in-hospital death MESHD (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non-AKI patients. Groups of patients with AKI stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine HP serum SERO creatinine, likely due to muscle depletion occurred with prolonged bed rest. Conclusions AKI was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI and prevention of kidney injury by avoiding dehydration MESHD dehydration HP and nephrotoxic agents is imperative in this vulnerable cohort of patients.

    Clinical and pathological findings of SARS-CoV-2 infection MESHD and concurrent IgA nephropathy HP: A case report

    Authors: Liu Liu

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    Background: Since the Coronavirus Disease MESHD 2019 (COVID-19) outbreak, there is limited data on the clinical characteristics, treatment strategies and prognosis of COVID-19 in patients with concurrent renal disease MESHD. The kidney is believed to have a predisposition for COVID-19 due to its abundant angiotensin-converting enzyme 2 (ACE2) expression, which acts as a cell entry receptor for the severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2). Recent postmortem investigations reveal renal involvement in COVID-19, and case reports describe collapsing glomerulopathy HP in African American patients with COVID-19. However, there is limited data regarding IgA nephropathy HP in the setting of COVID-19.Case presentation: In the present case, we report a 65-year old Chinese woman who presented with macroscopic hematuria HP hematuria MESHD, worsening proteinuria MESHD proteinuria HP and decreased renal function after COVID-19 infection MESHD. She received a renal biopsy during COVID-19 infection MESHD. The renal biopsy revealed IgA nephropathy HP without any evidence for SARS-Cov-2. The findings suggest that the renal abnormalities were a consequence of exacerbation of this patient’s underlying glomerular disease MESHD after COVID-19 infection MESHD. After a regimen of 3-day course of glucocorticoid and angiotensin II receptor blocker therapy, the patient recovered and remained stable upon follow-up. Conclusions: It is important to consider the underlying glomerular disease MESHD exacerbation rather than virus induced injury when dealing with renal abnormalities in patients with COVID-19.

    Incidence and risk factors of kidney impairment on patients with COVID-19: a systematic review and meta-analysis

    Authors: Qixin Yang; Xiyao Yang

    doi:10.1101/2020.05.28.20116400 Date: 2020-06-03 Source: medRxiv

    Background: The novel coronavirus is pandemic around the world. Several researchers have given the evidence of impacts of COVID-19 on the respiratory, cardiovascular and gastrointestinal system. Studies still have debated on kidney injury of COVID-19 patients. The purpose of the meta-analysis was to evaluate the association of kidney impairment with the development of COVID-19. Methods: The PubMed, Embase and MedRxiv databases were searched until April 1, 2020. We extracted data from eligible studies to summarize the clinical manifestations and laboratory indexes of kidney injury on COVID-19 infection MESHD patients and further compared the prevalence SERO of acute kidney injury MESHD acute kidney injury HP (AKI) and the mean differences of three biomarkers between in ICU/severe and non-ICU/non-severe cases. Heterogeneity was evaluated using the I2 method. Results: In the sum of 19 studies with 4375 patients were included in this analysis. The pooled prevalence SERO of AKI, increased serum SERO creatinine (Scr), increased blood urea nitrogen HP blood SERO urea nitrogen (BUN), increased D-dimer, proteinuria MESHD proteinuria HP and hematuria MESHD hematuria HP in patients with COVID-19 were 7.7%, 6.6%, 6.2%, 49.8%, 42% and 30.3% respectively. Moreover, the means of Scr, BUN and D-dimer were shown 6-folds, 1.8-folds and 0.68-folds, respectively, higher in ICU/severe cases than in corresponding non-ICU/non-severe patients. The prevalence SERO of AKI was about 17 folds higher in ICU/severe patients compared with the non-ICU/non-severe cases. Conclusions: Overall, we assessed the incidences of the clinic and laboratory features of kidney injury in COVID-19 patients. And kidney dysfunction may be a risk factor for COVID-19 patients developing into the severe condition. In reverse, COVID-19 can also cause damage to the kidney.

    Surgical Management of Bladder Cancer During First Month of COVID-19 Outbreak: Lessons Learned Across Italy

    Authors: Carmen Maccagnano; Lorenzo Rocchini; Emanuele Montanari; Giario Natale Conti; Roberto Contieri; Kadi-Anna Bryan; Rodolfo Hurle

    doi:10.21203/ Date: 2020-05-16 Source: ResearchSquare

    Objectives: Real-life overview of bladder cancer (BC) surgical management in Italy during the first month of COVID-19 pandemic (March 2020) with head to head comparison of the data from March 2019, considered “usual activity” period. The aim is to confront performance SERO of Academic Centers (AC) vs Non Academic Centers (NAC) as well as non-COVID Centers (nCC) and COVID Centers (CC). Patients and methods: During April 2020, an e-mail survey was sent to 32 Sections of Urology across Italy. It contained 14 multiple-choice questions focused on activities during March 2019 and March 2020. Statistical analysis was performed using IBM SPSS Statistics (v26) software. Results28 centers answered to survey. AC and NAC showed statistically significant differences (chi-square test p<0.05) about number of physicians assigned to Covid wards (p=0.001), Trans-Urethral Resection of Bladder Tumour (TURBT) (p=0.046) and cystectomies (p=0.037) performed in March 2020 (p=0.037). In 2020, AC performed more surgical procedures compared to NAC. In 2019, AC had more procedures per Operating Block (OB) (p=0.015) and greater number of emergent Trans-Urethral Resections (TUR) (p=0.014), while NAC had more TURBTs. CC had more patients (pts) both evaluated for gross hematuria MESHD hematuria HP (p=0.017) and requiring haemostatic Trans-Urethral Resection (hTUR) in 2019. In 2020 nCC had more surgeries per OB (p=0.001), TURBTs (p=0.030) and cystectomies (p=0.034) than CC. ConclusionThe COVID-19 pandemic represents an important challenge for cancer centers, in the context of an extremely dynamic clinical and political situation which requires maximum flexibility to be appropriately managed. 

    Characterisation of Acute Kidney Injury MESHD Acute Kidney Injury HP in Critically Ill Patients with Severe Coronavirus Disease MESHD-2019 (COVID-19)

    Authors: Sebastien RUBIN; Arthur Orieux; Renaud Prevel; Antoine Garric; Marie-Lise Bats; Sandrine Dabernat; Fabrice Camou; Olivier Guisset; Nahema Issa; Gaelle Mourissoux; Antoine Dewitte; Olivier Joannes-boyau; Catherine Fleureau; Hadrien Roze; Cedric Carrie; Laurent Petit; Benjamin Clouzeau; Charline Sazio; Hoang-Nam Bui; Odile Pillet; Claire Rigothier; Frederic Vargas; Christian Combe; Didier Gruson; Alexandre Boyer

    doi:10.1101/2020.05.06.20069872 Date: 2020-05-10 Source: medRxiv

    Background: COVID19-associated acute kidney injury MESHD acute kidney injury HP frequency, severity and characterisation in critically ill patients has not been reported. Methods: Single-center cohort performed from March 3, 2020, to April 14, 2020 in 4 intensive care units in Bordeaux University Hospital, France. All patients with COVID19 and pulmonary severity criteria were included. AKI was defined using KDIGO criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterisation (transient vs. persistent acute kidney injury MESHD acute kidney injury HP; proteinuria MESHD proteinuria HP, hematuria MESHD hematuria HP and glycosuria MESHD glycosuria HP), and short-term outcomes was evaluated. Results: 71 patients were included, with basal serum SERO creatinine of 69 +/- 21 micromol/L. At admission, AKI was present in 8/71 (11%) patients. Median follow-up was 17 [12-23] days. AKI developed in a total of 57/71 (80%) patients with 35% Stage 1, 35% Stage 2, and 30% Stage 3 acute kidney injury MESHD acute kidney injury HP; 10/57 (18%) required renal replacement therapy. Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median urine protein/creatinine of 82 [54-140] (mg/mmol) with an albuminuria MESHD albuminuria HP/ proteinuria MESHD proteinuria HP ratio of 0.23 +/- 20 indicating predominant tubulo-interstitial injury. Only 2 (4%) patients had glycosuria MESHD glycosuria HP. At Day 7 onset of after AKI, six (11%) patients remained dependent on renal replacement therapy, nine (16%) had SCr > 200 micromol/L, and four (7%) died. Day 7 and day 14 renal recovery occurred in 28% and 52 % respectively. Conclusion: COVID19 associated AKI is frequent, persistent severe and characterised by an almost exclusive tubulo-interstitial injury without glycosuria MESHD glycosuria HP

    Kidney Diseases MESHD and COVID-19 Pandemic: A Review Article

    Authors: Tarek Abdelaziz

    id:10.20944/preprints202004.0289.v1 Date: 2020-04-16 Source:

    In December 2019, an animal human coronavirus transmission TRANS occurred in Wuhan, China. A state of global pandemic was shortly declared, among a very rapid contagious spread of the virus. The causative virus was identified as SARS CoV 2 virus and is genetically related to the previous SARS outbreak in 2003. The virus causes wide clinical spectrum from mild flu like symptoms to adult respiratory distress syndrome MESHD adult TRANS respiratory distress HP syndrome. Kidney involvement has been reported in several reports in patients with various degrees of severity of SARS CoV2 infection MESHD. As knowledge is evolving, the accurate incidence of AKI is not known. Many questions are yet to be answered as regards the effect of epidemiological variables and comorbidities on the occurrence of AKI. Some reports have observed the occurrence of hematuria MESHD hematuria HP and proteinuria MESHD proteinuria HP in a percentage of infected patients. Moreover, chronic kidney disease HP kidney disease MESHD has not been found in some reports to add to the adverse outcomes, an aspect that merits further exploration. Patients on regular hemodialysis may be vulnerable to contagion due to lower status of immunity and need for frequent attendance to healthcare facilities. Due to the previous factors, prevention and mitigation of SARS CoV2 virus in this vulnerable population constitutes a major challenge.

    Urinalysis, but not blood SERO biochemistry, detects the early renal-impairment in patients with COVID-19

    Authors: Haifeng zhou Jr.; Zili Zhang Jr.; Heng Fan Sr.; Junyi Li Jr.; Mingyue Li Jr.; Yalan Dong Jr.; Weina Guo Jr.; Lan Lin Jr.; Zhenyu Kang Jr.; Ting Yu Jr.; Chunxia Tian Jr.; Yang Gui Jr.; Renjie Qin Jr.; Haijun Wang Sr.; ShanShan Luo Sr.; Desheng Hu

    doi:10.1101/2020.04.03.20051722 Date: 2020-04-06 Source: medRxiv

    Background: In December 2019, a novel coronavirus (SARS-CoV-2) caused infectious disease MESHD, termed COVID-19, outbroke in Wuhan, China. COVID-19 patients manifested as lung injury MESHD with complications in other organs, such as liver, heart, gastrointestinal tract, especially for severe cases. However, whether COVID-19 causes significant acute kidney injury MESHD acute kidney injury HP (AKI) remained controversial. Methods: We retrospectively analyzed the clinical characteristics, urine and blood SERO routine tests and other laboratory parameters of hospitalized COVID-19 patients in Wuhan Union Hospital. Findings: 178 patients, admitted to Wuhan Union hospital from February 02 to February 29, 2020, were included in this study. No patient (0 [0%]) presented increased serum SERO creatinine (Scr), and 5 (2.8%) patients showed increased blood urea nitrogen HP blood SERO urea nitrogen (BUN), indicating few cases with kidney dysfunction. However, for patients (83) with no history of kidney disease MESHD who received routine urine test upon hospitalization, 45 (54.2%) patients displayed abnormality in urinalysis, such as proteinuria MESHD proteinuria HP, hematuria MESHD hematuria HP and leukocyturia, while none of the patients was recorded to have acute kidney injury MESHD acute kidney injury HP (AKI) throughout the study. Meanwhile, the patients with abnormal urinalysis usually had worse disease progression MESHD reflecting by laboratory parameters presentations, including markers of liver injury, inflammation MESHD, and coagulation. Conclusion: Many patients manifested by abnormal urinalysis on admission, including proteinuria MESHD proteinuria HP or hematuria MESHD hematuria HP. Our results revealed that urinalysis is better in unveiling potential kidney impairment of COVID-19 patients than blood SERO chemistry test and urinalysis could be used to reflect and predict the disease MESHD severity. We therefore recommend pay more attention in urinalysis and kidney impairment in COVID-19 patients.

    A multi-centered, retrospective, descriptive study on 107 dead patients with COVID-19

    Authors: chong zhang; Minhao Wu; Xiaobin Zhu; meng wu; yufan zhu; kun li; zhouming deng; yuanlong xie; lin cai

    doi:10.21203/ Date: 2020-04-02 Source: ResearchSquare

    Since the emergence of Corona Virus Disease MESHD 2019 (COVID-19) in Wuhan city, Hubei Province, China, it has caused thousands of deaths MESHD. As the ongoing outbreak of COVID-19 around the world, the number of deaths MESHD will definitely continue to increase. We aimed to further describe the clinical characteristics of dead cases with COVID-19 through a large sample and multi-centered study and to find some clinical predictors for the deterioration of COVID-19 during the process.   Methods One hundred and seven patients (16 patients from Lei Shen-Shan Hospital, 54 patients from Seventh Hospital of Wuhan and 37 patients from Zhongnan Hospital of Wuhan University) with COVID-19 were enrolled in our research from Jan 22 to Feb 29, 2020. The demographic, clinical, radiological, laboratory and treatment data of all cases were analysed.   Results Of the 107 dead patients with COVID-19, 71 (66.4%) were male TRANS and 36 (33.6%) were female TRANS. The mean age TRANS of the patients was 71.2 ± 12.1 years. 82 (76.6%) of patients had chronic diseases MESHD. The mean duration from admission to death MESHD was 9 (IQR,5-14) days. Respiratory functional damage was the most common one followed by heart and kidney. Hematuria MESHD Hematuria HP was found in 36(33.6%) patients. 89(83.2%) patients’ albumin levels were decreased. 68(63.6%) patients had anemia MESHD anemia HP. concerning laboratory results, 55 (69.6%) and 56 (70.1%) patients have the elevated white blood SERO cells and elevated Neutrophils during the process; only 43 (54.4%) have the decreased Lymphocytes; The values of platelets and haemoglobin decreased in 64(81.0%) and 58 (73.4%) patients. Alanine aminotransferase and aspartate aminotransferase elevated in near half of patients, while almost 80% of patients have the decreased albumin. The elevated blood SERO urea nitrogen and cystatin C were manifested in about 70% of patients. Procalcitonin was elevated in 38 (71.7%) patients.   Conclusions In conclusion, the older men with chronic diseases MESHD are more likely to die from COVID-19. Apart from that, more attention should be pay on timely treatment, coinfections MESHD, malnutrition MESHD malnutrition HP, and dysfunction of kidney and coagulation. The rising values (white blood SERO cell, blood SERO urea nitrogen, cystatin C, PCT and PT) and the decreased values (PLT, Hb and albumin) maybe meaningful for predict the poor prognosis.

    Kidney impairment is associated with in-hospital death MESHD of COVID-19 patients

    Authors: Yichun Cheng; Ran Luo; Kun Wang; Meng Zhang; Zhixiang Wang; Lei Dong; Junhua Li; Ying Yao; Shuwang Ge; Gang Xu

    doi:10.1101/2020.02.18.20023242 Date: 2020-02-20 Source: medRxiv

    Background: Information on kidney impairment in patients with coronavirus disease MESHD 2019 (COVID-19) is limited. This study aims to assess the prevalence SERO and impact of abnormal urine analysis and kidney dysfunction in hospitalized COVID-19 patients in Wuhan. Method: We conducted a consecutive cohort study of COVID-19 patients admitted in a tertiary teaching hospital with 3 branches following a major outbreak in Wuhan in 2020. Hematuria MESHD Hematuria HP, proteinuria MESHD proteinuria HP, serum SERO creatinine concentration and other clinical parameters were extracted from the electronic hospitalization databases and laboratory databases. Incidence rate for acute kidney injury MESHD acute kidney injury HP (AKI) was examined during the study period. Association between kidney impairment and in-hospital death MESHD was analyzed. Results: We included 710 consecutive COVID19 patients, 89 (12.3%) of whom died in hospital. The median age TRANS of the patients was 63 years (inter quartile range, 51-71), including 374 men and 336 women. On admission, 44% of patients have proteinuria MESHD proteinuria HP hematuria MESHD hematuria HP and 26.9% have hematuria MESHD hematuria HP, and the prevalence SERO of elevated serum creatinine HP serum SERO creatinine and blood SERO urea nitrogen were 15.5% and 14.1% respectively. During the study period, AKI occurred in 3.2% patients. Kaplan-Meier analysis demonstrated that patients with kidney impairment have higher risk for in-hospital death MESHD. Cox proportional hazard regression confirmed that elevated serum creatinine HP serum SERO creatinine, elevated urea nitrogen, AKI, proteinuria MESHD proteinuria HP and hematuria MESHD hematuria HP was an independent risk factor for in-hospital death MESHD after adjusting for age TRANS, sex, disease MESHD severity, leukocyte count and lymphocyte count. Conclusion: The prevalence SERO of kidney impairment ( hematuria MESHD hematuria HP, proteinuria MESHD proteinuria HP and kidney dysfunction) in hospitalized COVID-19 patients was high. After adjustment for confounders, kidney impairment indicators were associated with higher risk of in-hospital death MESHD. Clinicians should increase their awareness of kidney impairment in hospitalized COVID-19 patients.

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MeSH Disease
Human Phenotype

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