Background: In December 2019, a novel coronavirus (SARS-CoV-2) caused infectious disease MESHD, termed COVID-19, outbroke in Wuhan, China. COVID-19 patients manifested as lung injury MESHD with complications in other organs, such as liver, heart, gastrointestinal tract, especially for severe cases. However, whether COVID-19 causes significant acute kidney injury MESHD acute kidney injury HP (AKI) remained controversial. Methods: We retrospectively analyzed the clinical characteristics, urine and blood SERO routine tests and other laboratory parameters of hospitalized COVID-19 patients in Wuhan Union Hospital. Findings: 178 patients, admitted to Wuhan Union hospital from February 02 to February 29, 2020, were included in this study. No patient (0 [0%]) presented increased serum SERO creatinine (Scr), and 5 (2.8%) patients showed increased blood urea nitrogen HP blood SERO urea nitrogen (BUN), indicating few cases with kidney dysfunction. However, for patients (83) with no history of kidney disease MESHD who received routine urine test upon hospitalization, 45 (54.2%) patients displayed abnormality in urinalysis, such as proteinuria MESHD proteinuria HP, hematuria MESHD hematuria HP and leukocyturia, while none of the patients was recorded to have acute kidney injury MESHD acute kidney injury HP (AKI) throughout the study. Meanwhile, the patients with abnormal urinalysis usually had worse disease progression MESHD reflecting by laboratory parameters presentations, including markers of liver injury, inflammation MESHD, and coagulation. Conclusion: Many patients manifested by abnormal urinalysis on admission, including proteinuria MESHD proteinuria HP or hematuria MESHD hematuria HP. Our results revealed that urinalysis is better in unveiling potential kidney impairment of COVID-19 patients than blood SERO chemistry test and urinalysis could be used to reflect and predict the disease MESHD severity. We therefore recommend pay more attention in urinalysis and kidney impairment in COVID-19 patients.