Corpus overview


Overview

MeSH Disease

Human Phenotype

Cough (2)

Fever (2)

Hemolytic anemia (1)

Myalgia (1)

Nausea (1)


Transmission

Seroprevalence
    displaying 1 - 3 records in total 3
    records per page




    Elevated oxygen demand in a case of COVID-19 with severe ARDS: a point for optimal oxygenation therapy including ECMO management

    Authors: Taku Oshima; Takehiko Oami; Mana Yamashiro; Akiko Higashi; Yosuke Hayashi; Natsumi Suga; Shin Takayanagi; Seiichiro Sakao; Taka-aki Nakada

    doi:10.21203/rs.3.rs-51286/v1 Date: 2020-07-30 Source: ResearchSquare

    Background: Coronavirus disease MESHD 2019 (COVID-19) caused by SARS-CoV-2 has become a global pandemic, and those developing critically ill conditions have been reported to have mortality in the range of 39% to 61%. Due to the lack of definitive treatments, mechanical ventilation and supportive oxygenation therapy are key management strategies for the survival of patients with acute respiratory distress HP syndrome MESHD (ARDS). Optimizing oxygenation therapy is mandatory to treat patients with severe respiratory failure HP, to sufficiently compensate for the oxygen (O2) demand. We experienced a case of severe ARDS due to COVID-19 successfully treated with extracorporeal membrane oxygenation (ECMO) after increasing oxygen delivery according to O2 consumption measurement by indirect calorimetryCase Presentation: A 29-year-old obese but otherwise healthy man was hospitalized for treatment of COVID-19 pneumonia MESHD pneumonia HP presenting with a 4-day history of persisting cough MESHD cough HP, high fever MESHD fever HP, and dyspnea MESHD dyspnea HP. Mechanical ventilation, nitric oxide inhalation, and prone positioning were initiated in the ICU against severe respiratory dysfunction. Indirect calorimetry on the 3rd and 6th ICU days revealed persistent elevation of oxygen consumption (VO2) of 380 mL/min. Veno-venous ECMO was initiated on the 7th ICU day after further deterioration of respiratory failure HP. Periodic events of SpO2 decline due to effortful breathing was not resolved by neuromuscular blockade in attempt to reduce O2 consumption. Increasing the ECMO flow induced hemolysis MESHD and hyperkalemia MESHD hyperkalemia HP despite the use of large bore cannulas and ECMO circuit free of clots and defects. The hemoglobin management level was elevated from 10 g/dL to 13 g/dL to increase blood SERO oxygen capacity, enabling the reduction of ECMO flow while attenuating respiratory effort and maintaining SpO2. Lung protective ventilation strategy and prone positioning were continued for successful weaning from ECMO on the 16th ICU day, and the ventilator on the 18th ICU day.Conclusion: The present case of severe ARDS due to COVID-19 was successfully treated with ECMO. Enhancing oxygen delivery was crucial to compensate for the elevated O2 demand. Measuring O2 consumption by indirect calorimetry can elucidate the oxygen demand for optimizing the oxygenation therapy for successful management and survival of critically ill COVID-19 patients. 

    COVID-19 Infection MESHD Associated With Auto-immune Hemolytic Anemia MESHD Hemolytic Anemia HP

    Authors: Antoine Capes; Sarah Bailly; Philippe Hantson; Ludovic Gerard; Pierre-François Laterre

    doi:10.21203/rs.3.rs-33157/v1 Date: 2020-06-02 Source: ResearchSquare

    A 62-y-old man developed Covid-19 infection MESHD. Fourteen days after the first respiratory symptoms, he presented biological signs of hemolysis MESHD with cold agglutinins 1/16384. Other causes of auto-immune hemolytic anemia MESHD hemolytic anemia HP (infectious, hematological,…) were excluded.

    Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery

    Authors: Louise Ronnje; John-Kalle Länsberg; Olga Vikhareva; Stefan Hansson; Andreas Herbst; Mehreen Zaigham

    doi:10.21203/rs.3.rs-31225/v1 Date: 2020-05-25 Source: ResearchSquare

    BackgroundIt has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infectionCase presentationA 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough MESHD cough HP, myalgia MESHD myalgia HP, nausea MESHD nausea HP, abdominal pain MESHD abdominal pain HP and fever MESHD fever HP. A nasopharyngeal swab returned positive for severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency MESHD Caesarean section was performed at gestational week 32+6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP ( Hemolysis MESHD, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection MESHD could not be ruled out. There was no evidence of vertical transmission TRANS. ConclusionThis case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection MESHD during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.