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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Predictive criteria of severe cases in COVID-19 patients of early stage

    Authors: Jinrui Gao; Xiu Huang; Haibo Gu; Lingyun Lou; Zhihao Xu

    doi:10.21203/rs.3.rs-39161/v1 Date: 2020-06-30 Source: ResearchSquare

    Background: Patients with coronavirus disease MESHD 2019 (COVID-19) often suffer sudden deterioration of disease MESHD around 1 to 2 weeks after onset. Once the disease MESHD progressed to severe phase, clinical prognosis of patients will significantly deteriorate.Methods: This was a multicenter retrospective study on patients of all adult TRANS inpatients (≥18 years old) from Tianyou Hospital (Wuhan, China) and the Fourth Affiliated Hospital, Zhejiang University School of Medicine. All 139 patients had laboratory-confirmed COVID-19 in their early stage, which is defined as within 7 days of clinical symptoms or within 7 days of positive viral nucleic acid test for asymptomatic TRANS patients. Univariate and multivariate logistic regression models were used to determine the predictive factors in the early detection of patients who may subsequently develop into severe cases.Results: Multivariable logistic regression analysis showed that the higher level of hypersensitivity MESHD C-reactive protein (OR=4.77, 95% CI:1.92-11.87, P=0.001), elevated alanine aminotransferase (OR=6.87, 95%CI:1.56-30.21, P=0.011) and chronic comorbidities (OR=11.48, 95% CI:4.44-29.66, P<0.001) are the determining risk factors for the progression into severe pneumonia MESHD pneumonia HP in COVID-19 patients.Conclusion: Early COVID-19 patients with chronic comorbidities, elevated hs-CRP or elevated ALT are significantly more likely to develop severe pneumonia MESHD pneumonia HP as the disease MESHD progresses. These risk factors may facilitate the early diagnosis of critical patients in clinical practice.

    Protective Factors and Risk Factors in Patients with COVID-19 Pneumonia MESHD Pneumonia HP and/or Infection MESHD

    Authors: Jia-Xia Li; Li Wan; Yuan Feng; Huilin Zuo; Jiecheng Ren; Qian Zhao; Mingwu Xia; Xiaochu Zhang

    doi:10.21203/rs.3.rs-36747/v1 Date: 2020-06-19 Source: ResearchSquare

    This study examined 50 COVID-19 patients who have been cured in Anhui Province, China. The protective factors and risk factors for these patients were investigated. By comparing CT-negative and CT-positive patients, we found protective factors in blood SERO: lymphocytes, eosinophils number and %, basophils%, reticulocyte%, high fluorescence reticulocyte ratio, and reticulocyte absolute value. Comparing patients with underlying disease MESHD and without underlying disease MESHD, we found protective factors in blood SERO: lymphocytes%, basophils%, large platelets, and low-fluorescent reticulocyte ratio. Regarding the biochemistry indicators, albumin/globulin, apolipoprotein and prealbumin can be considered as protective factors for patients without lung symptoms. Urea, glucose, total bile aicd, creatinine and hypersensitivity MESHD CRP can be considered as risk factors for patients with underlying diseases MESHD. For patients with repeatedly negative and positive results in nucleic acid tests, they were at a medium level in terms of both protective and risk factors, explaining the mild symptoms and repeatedly results in nucleic acid tests.

    Clinical course and features of critical patients with COVID-19: a single- center, retrospective study from Wuhan Huoshenshan Hospital

    Authors: Huisi He; Zhichao Jin; Yibin Ren; Junxue Wang; Wen Wen; Yushan Miao; Xuewei Qi; Taiyu Shang; Chenxu Zhang; Hongyang Wang; Weiqin Li; Xijing Zhang; Hao Tang

    doi:10.21203/rs.3.rs-27487/v1 Date: 2020-05-08 Source: ResearchSquare

    Background : The coronavirus pandemic has become a growing public health concern worldwide, and there are insufficient epidemiological data on critical illness MESHD. Objective: To investigate the clinical course and features of critical patients with Corona Virus Disease MESHD 2019 ( COVID-19 ). Methods: The data on 94 consecutive critical patients from 8 th February through 16 th March 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed. Results: Over the study period, 42 nonsurvivors and 52 survivors were included. The overall case fatality rate for critical patients with COVID-19 was approximately 45%. The average age TRANS was 69.17±9.55 years, and the majority had underlying health problems such as hypertension MESHD hypertension HP (56[60%]) and diabetes (18[19%]). The median length of ICU stay was 8 days (IQR 4, 13). Compared with survivors, nonsurvivors were more likely to develop sepsis MESHD sepsis HP (42[100%] vs. 34[65%]), acute respiratory distress HP syndrome MESHD (40[95%] vs. 28[54%]) and organ dysfunction. In addition, the dynamic changes in some biomarkers were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths MESHD (93.33%). Conclusions: Patients aged TRANS 60 years or older with many concomitant diseases MESHD were at highest risk, and the fatality rate started to increase with age TRANS. Lymphocyte, platelet, C-reactive protein and hypersensitivity MESHD troponin I were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.

    Clinical course and features of critical patients with COVID-19: a single-center, retrospective study from Wuhan Huoshenshan Hospital

    Authors: Huisi He; Zhichao Jin; Yibin Ren; Junxue Wang; Wen Wen; Yushan Miao; Xuewei Qi; Taiyu Shang; Chenxu Zhang; Hongyang Wang; Weiqin Li; Xijing Zhang; Hao Tang

    doi:10.21203/rs.3.rs-21014/v1 Date: 2020-04-03 Source: ResearchSquare

    Background and Aims: The coronavirus pandemic has become a growing public health concern worldwide, and there are insufficient epidemiological data on critical illness MESHD. We sought to investigate the clinical course and features of critical patients with Corona Virus Disease MESHD 2019 (COVID-19).Method: The data on 94 critical patients from 8th February through 16th March 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed.Results: Over the study period, 42 nonsurvivors and 52 survivors were included. The overall case fatality rate for critical patients with COVID-19 was approximately 45%. The average age TRANS was 69.17±9.55 years, and the majority had underlying health problems such as hypertension MESHD hypertension HP (56[60%]) and diabetes (18[19%]). The median length of ICU stay was 8 days (IQR 4, 13). Compared with survivors, nonsurvivors were more likely to develop sepsis MESHD sepsis HP (42[100%] vs. 34[65%]), acute respiratory distress HP syndrome MESHD (40[95%] vs. 28[54%]) and organ dysfunction. In addition, the dynamic changes in some biomarkers were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths MESHD (93.33%).Conclusion: Patients aged TRANS 60 years or older with many concomitant diseases MESHD were at highest risk, and the fatality rate started to increase with age TRANS. Lymphocyte, platelet, C-reactive protein and hypersensitivity MESHD troponin I were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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