Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 2 records in total 2
    records per page

    Cardiac Troponin I Associated with Poor Prognosis and Death MESHD Risk in 726 Severe and Critical COVID-19 Patients: A Retrospective Cohort Study

    Authors: Huilong Chen; Xinjie Li; Tuohutaerbieke Marmar; Qiang Xu; Jing Tu; Tong Li; Jun Han; Dong Xu; Tao Shen

    doi:10.21203/ Date: 2020-07-28 Source: ResearchSquare

    Background: A few patients with coronavirus disease MESHD 2019 (COVID-19) may progress into irreparable outcomes. Early identification of patients with serious symptoms who may develop critical illness MESHD and even death MESHD is of considerable importance for personalizing treatment and balancing medical resources.Methods: In this retrospective study, demographic, clinical characteristics and laboratory tests from 726 patients with serious COVID-19 from Tongji Hospital (Wuhan, China) were analyzed. The standards for the serious type are guided by the Chinese management guideline for COVID-19. Patients were classified into critical group (174 cases) and severe group (552 cases) based on whether the composite endpoint was reached, and the former group was divided into the survivors (47 cases) and non-survivors (127 cases). Univariable and multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed to investigate the risk factors associated with poor prognosis and mortality outcomes.Results: Male TRANS patients accounted for 62.1% and 51.6% in the critical group and severe group, with a median age TRANS of 68 and 65 years, respectively. Among critical cases there was a higher prevalence SERO of chronic obstructive lung disease MESHD obstructive lung disease HP (p = 0.029) and chest distress (p = 0.040) than in severe cases. In the multivariable analysis, the risk factors associated with poor prognosis in severe cases were advanced age TRANS (p = 0.002), high respiratory rate (RR) (p < 0.0001), high lactate dehydrogenase (LDH) level (p = 0.021), high hypersensitive cardiac troponin I (hs-cTnI) level (p < 0.0001), and low platelet counts (p = 0.005) at admission. In the adjusted models, higher mortality outcomes in critical patients were associated with high hs-cTnI level (p = 0.037). By plotting ROC curves of different indices, hs-cTnI and LDH were found to be predictive factors for poor prognosis in patients with severe COVID-19.Conclusions: For the risk assessment of serious COVID-19 patients on admission, advanced age TRANS, high level of RR, LDH, hs-cTnI, and low platelet counts, constitute important risk factors for poor prognosis in severe cases, and the hs-cTnI level can be helpful in predicting fatal outcomes in critically ill patients.

    ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19

    Authors: Bruna GG Pinto; Antonio ER Oliveira; Youvika Singh; Leandro Jimenez; Andre NA Goncalves; Rodrigo LT Ogava; Rachel Creighton; Jean PS Peron; Helder I Nakaya

    doi:10.1101/2020.03.21.20040261 Date: 2020-03-27 Source: medRxiv

    The pandemic caused by the Severe Acute Respiratory Syndrome MESHD Coronavirus 2 (SARS-CoV-2) has resulted in several thousand deaths MESHD worldwide in just a few months. Patients who died from Coronavirus disease MESHD 2019 (COVID-19) often had comorbidities, such as hypertension MESHD hypertension HP, diabetes, and chronic obstructive lung disease MESHD obstructive lung disease HP. The angiotensin-converting enzyme 2 (ACE2) was identified as a crucial factor that facilitates SARS-CoV2 to bind and enter host cells. To date, no study has assessed the ACE2 expression in the lungs of patients with these diseases MESHD. Here, we analyzed over 700 lung transcriptome samples of patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients, compared to control individuals. This finding suggests that patients with such comorbidities may have higher chances of developing severe COVID-19. We also found other genes, such as RAB1A, that can be important for SARS-CoV-2 infection MESHD in the lung. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. In fact, epigenetic marks found in ACE2 locus were compatible to with those promoted by KDM5B. Our systems biology approach offers a possible explanation for increase of COVID-19 severity in patients with certain comorbidities.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.