Corpus overview


MeSH Disease

Human Phenotype


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    Review of clinical characteristics and laboratory findings of COVID-19 in children TRANS-Systematic review and Meta-analysis

    Authors: Harmeet K Kharoud; Rizwana Asim; Lianne Siegel; Lovepreet Chahal; Gagan Deep Singh; Anna Marit de Groot; Jeroen Stoop; Sarah Tete; Wim Van Damme; Isabel Leroux-Roels; Pieter-Jan Berghmans; Murray Kimmel; Pierre Van Damme; Jan De Hoon; William Smith; Kathryn Stephenson; Dan Barouch; Stephen De Rosa; Kristen Cohen; Juliana McElrath; Emmanuel Cormier; Gert Scheper; Jenny Hendriks; Frank Struyf; Macaya Douoguih; Johan Van Hoof; Hanneke Schuitemaker

    doi:10.1101/2020.09.23.20200410 Date: 2020-09-25 Source: medRxiv

    OBJECTIVE: To conduct a systematic review and meta-analysis to assess the prevalence SERO of various clinical symptoms and laboratory findings of COVID-19 in children TRANS. METHODS: PubMed, MEDLINE, and SCOPUS databases were searched to include studies conducted between January 1, 2020, and July 15, 2020 which reported data about clinical characteristics and laboratory findings in laboratory-confirmed diagnosis of COVID-19 in pediatric patients. Random effects meta-analysis using generalized linear mixed models was used to estimate the pooled prevalence SERO. RESULTS: The most prevalent symptom of COVID-19 in children TRANS was 46.17% (95%CI 39.18-53.33%), followed by cough HP (40.15%, 95%CI 34.56-46.02%). Less common symptoms were found to be dyspnea HP dyspnea MESHD, vomiting HP vomiting MESHD, nasal congestion/ rhinorrhea HP rhinorrhea MESHD, diarrhea HP diarrhea MESHD, sore throat/pharyngeal congestion, headache HP headache MESHD, and fatigue HP fatigue MESHD. The prevalence SERO of asymptomatic TRANS children TRANS was 17.19% (95%CI 11.02-25.82%). The most prevalent laboratory findings in COVID-19 children TRANS were elevated Creatinine Kinase (26.86%, 95%CI 16.15-41.19%) and neutropenia HP neutropenia MESHD (25.76%, 95%CI 13.96-42.58%). These were followed by elevated LDH, thrombocytosis HP thrombocytosis MESHD, lymphocytosis HP lymphocytosis MESHD, neutrophilia HP, elevated D Dimer, Elevated CRP, elevated ESR, leukocytosis HP leukocytosis MESHD, elevated AST and leukopenia HP leukopenia MESHD. There was a low prevalence SERO of elevated ALT and lymphopenia HP lymphopenia MESHD in children TRANS with COVID- 19. CONCLUSIONS AND RELEVANCE: This study provides estimates of the pooled prevalence SERO of various symptoms and laboratory findings of COVID-19 in the pediatric population.

    Why Children TRANS Are Less Affected by COVID-19 Than Adults TRANS: Potential Immunological Factors and the Renin-Angiotensin System Associated Mechanisms

    Authors: Olga Krogh-Jensen; Irina Nikitina; Andrew Donnikov; Anna Lenyushkina; Nataliya Degtyareva; Anna Degtyareva

    id:10.20944/preprints202006.0120.v1 Date: 2020-06-09 Source:

    The spread of the infection MESHD caused by the new coronavirus SARS-CoV-2 (COVID-19) became pandemic on March 11, 2020. From the time of the first cases (in November 2019, Wuhan, China), to date, a large number of COVID-19 observations have been accumulated in different age groups TRANS of patients both in China and abroad. Published scientific data allows us to conclude that children TRANS suffer from COVID-19 much less often than adults TRANS and tolerate the disease in a milder form, often appear to be asymptomatic TRANS. There is currently no final answer why children TRANS are less susceptible to this virus; however, scientists are increasingly inclined to consider a complex effect of the immune response and components of the renin-angiotensin system (RAS), which according to recent studies affects not only the cardiovascular system, but is also responsible for the activation of inflammatory reactions. A hypothesis of genetic predisposition to the development of severe forms of COVID-19 has recently been made. We conducted a search for publications in the databases and showed current scientific ideas about COVID-19 pathogenesis and factors influencing the disease development in childhood. Childhood immunity may have several protective features against SARS-CoV-2: immaturity of particular elements of the innate immune response, constitutional lymphocytosis HP lymphocytosis MESHD with a shift towards anti-inflammatory Th2-response, as well as "trained" immunity. The influence of renin-angiotensin system reactions in this review is shown from two perspectives: expression of ACE2 receptors and polymorphisms of certain genes of this system. It was established that ACE2 transmembrane protein is not only the entry point for the virus but also plays a regulatory role, turning the pro-inflammatory vasoconstrictor angiotensin II into anti-inflammatory angiotensin (1-7), which has vasodilating properties. Higher ACE2 content in children TRANS compared with adults TRANS helps maintain balance in the renin-angiotensin system and prevents the development of complications. It was also shown that the presence of certain genetic polymorphisms (AGTR1, AGTR2, ACE2, ACE) could determine the imbalance inside the RAS, leading to more pronounced reactions of alveolocytes, vascular endothelium and smooth muscle fibers in response to SARS-CoV-2 infection MESHD due to a shift towards vasoconstrictor, proliferative and profibrotic mechanisms.

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MeSH Disease
Human Phenotype

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