Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 8 records in total 8
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    Varicella Zoster Virus Induced Acute Retinal Necrosis MESHD Following Acute Meningoencephalitis MESHD in a Patient with Presumed COVID-19

    Authors: Kiana Hassanpour; Faezeh Khorasanizadeh ; Hamid Ahmadieh; Mahmood Nabavi; Narsis Daftarian; Alireza Ramezani

    doi:10.21203/ Date: 2020-08-05 Source: ResearchSquare

    Background: To report the coincidence of acute retinal necrosis syndrome MESHD (ARN) following acute meningoencephalitis MESHD and presumed coronavirus disease MESHD 2019 (COVID-19) in an immunocompetent patient. Case presentation: A 58-year old female TRANS presented to our emergency MESHD department complaining of sudden unilateral visual loss HP following a recent hospitalization for a viral meningoencephalitis MESHD. Magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, polymerase chain reaction (PCR) of the aqueous humor, reverse transcriptase polymerase chain reaction (RT-PCR) of the nasopharyngeal swab specimen, chest computed tomography (CT), and fundus photography were performed for the patient. Ophthalmic examination revealed severe ocular inflammation MESHD and yellowish patches of necrotizing retinitis MESHD retinitis HP in the right eye compatible with the diagnosis of ARN. The result of PCR on the aqueous humor was positive for VZV. The patient received one intravitreal ganciclovir injection and 10 days intravenous ganciclovir followed by oral acyclovir. The patient underwent COVID-19 screening tests; chest CT-scan showed the features highly suggestive for COVID-19 while the RT-PCR was negative two times. Two months later, BCVA reached 20/70 in the right eye. The anterior chamber reaction and KPs resolved and the vitreous haziness significantly decreased Conclusion: A case of VZV induced ARN following acute meningoencephalitis MESHD was observed in association with presumed COVID-19. This could be an incidental finding in the pandemic era of COVID-19; however, it could also suggest that COVID-19 might trigger ARN in cases having latent herpes family viruses. 

    Indication for SARS-CoV-2 serology: first month follow-up

    Authors: Alix T. Coste; Katia Jaton; Matthaios Papadimitriou-Olivgeris; Antony Croxatto; Gilbert Greub

    doi:10.1101/2020.06.30.20140715 Date: 2020-07-03 Source: medRxiv

    SARS-CoV-2 detection is mainly performed by RT-PCR but recently serological tests SERO were made available. A first one month follow-up of the SARS-CoV-2 serology records was performed in our laboratory to precise the diversity and proportion of the SARS-CoV-2 serology test indications and to identify new valid indications ( meningoencephalitis MESHD, vasculitis MESHD vasculitis HP, etc)

    Meningoencephalitis MESHD associated with COVID-19: A systematic review

    Authors: Ritwick Mondal; Upasana Ganguly; Shramana Deb; Gourav Shome; Subhasish Pramanik; Deebya Bandyopadhyay; Durjoy Lahiri

    doi:10.1101/2020.06.25.20140145 Date: 2020-06-26 Source: medRxiv

    Background and aims: With the growing number of COVID-19 cases in recent times, the varied range of presentations is progressively becoming an addressing issue among clinicians. A significant set of patients with extra pulmonary symptoms has been reported worldwide. Neurological involvement in the form of altered mental status, loss of consciousness HP in considerable amounts has drawn attention of physicians all across the globe. Here we venture out to summarise the clinical profile, investigations and radiological findings among patients with SARS-CoV-2 associated meningoencephalitis MESHD in the form of a systematic review, which may aid clinicians in early diagnosis and prognostic evaluation of the disease MESHD. Methodology: This review was carried out based on the existing PRISMA (Preferred Report for Systemic Review and Meta analyses) consensus statement. The data for this review was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase and Cochrane library and Preprint servers up till 10th June, 2020. Search strategy comprised of a range of keywords from relevant medical subject headings which includes "SARS-COV-2", "COVID-19", " meningoencephalitis MESHD" etc. All peer reviewed, case control, case report, pre print articles satisfying our inclusion criteria were involved in the study. The inclusion prerequisites comprised of confirmed SARS-CoV-2 cases with neurological manifestations, previous cases of SARS-CoV, MERS-CoV with neurological involvement provided all the studies were published in English language. Quantitative data was expressed in mean+/-SD, while the qualitative date in percentages. Paired t test was used for analysing the data based on differences between mean and respective values with a p value of <0.05 considered to be statistically significant. Results: A total of 43 cases were involved from 24 studies after screening from databases and preprint servers, out of which 29 of them had completed investigation profile and were included in the final analysis. Clincial and Laboratory findings as well as neuroimaging findings (CT, MRI and MRS) revealed consistent presentations towards association of COVID-19 with meningoencephalitis MESHD. Epileptogenic pictures were also evident on EEG (electroencephalogram) findings. Conclusion: SARS-CoV-2 has been isolated from CSF as well as cerebrum of cases with meningoencephalitis MESHD depicting the natural tendency of the virus to invade the central nervous system. Speculations about retrograde olfactory transport or alternative haematogenous spread seem to be correlating with above findings. This review may raise the index of suspicion about COVID-19 among clinicians while attending patients with neurological manifestations.

    Neurological manifestations of COVID-19: A systematic review

    Authors: Xiangliang Chen; Sarah Laurent; Oezguer A. Onur; Nina N. Kleineberg; Gereon R. Fink; Finja Schweitzer; Clemens Warnke

    doi:10.21203/ Date: 2020-06-23 Source: ResearchSquare

    Objective: To study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature. Methods: Relevant studies were identified through electronic explorations of PubMed, medRxiv, and bioRxiv. Besides, three Chinese databases were searched. A snowballing method searching the bibliographies of the retrieved references was applied to identify potentially relevant articles. Articles published within one year prior to April 20th, 2020 were screened with no language restriction imposed. Databases were searched for terms related to SARS-CoV-2/COVID-19 and neurological manifestations, using a pre-established protocol registered on the International Prospective Register of Systematic Reviews database (ID: CRD42020187994).Results: A total of 2441 articles were screened for relevant content, of which 92 full-text publications were included in the analyses of neurological manifestations of COVID-19. Headache MESHD Headache HP, dizziness MESHD, taste and smell dysfunctions, and impaired consciousness were the most frequently described neurological symptoms, the latter more often among patients with a severe or critical disease MESHD course. To date, only smaller cohort studies or single cases have reported cerebrovascular events, seizures MESHD seizures HP, meningoencephalitis MESHD, and immune-mediated neurological diseases MESHD, not suitable for quantitative analysis. Conclusions: The most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection MESHD with SARS-CoV-2. Although SARS-CoV-2 may have the potential to gain direct access to the nervous system, so far, SARS-CoV-2 was detected in the cerebrospinal fluid in two cases only. Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2. 

    Fatal Central Nervous System Co- Infection MESHD with SARS-CoV-2 and Tuberculosis MESHD in a Healthy Child TRANS

    Authors: Bishara J. Freij; Bassam M. Gebara; Rabail Tariq; Ay-Ming Wang; John Gibson; Nidal El-Wiher; Graham Krasan; Paul M. Patek; Kelly A. Levasseur; Mitual Amin; Joseph M. Fullmer

    doi:10.21203/ Date: 2020-06-04 Source: ResearchSquare

    Background. Central and peripheral nervous system symptoms and complications are being increasingly recognized among individuals with pandemic SARS-CoV-2 infections MESHD, but actual detection of the virus or its RNA in the central nervous system has rarely been sought or demonstrated. Severe or fatal illnesses are attributed to SARS-CoV-2, generally without attempting to evaluate for alternative causes or co-pathogens.Case presentation. A five-year-old girl with fever MESHD fever HP and headache MESHD headache HP was diagnosed with acute SARS-CoV-2-associated meningoencephalitis MESHD based on the detection of its RNA on a nasopharyngeal swab, cerebrospinal fluid analysis, and magnetic resonance imaging findings. Serial serologic tests SERO for SARS-CoV-2 IgG and IgA showed seroconversion, consistent with an acute infection MESHD. Mental status and brain imaging findings gradually worsened despite antiviral therapy and intravenous dexamethasone. Decompressive suboccipital craniectomy for brain herniation with cerebellar biopsy on day 30 of illness, shortly before death MESHD, revealed SARS-CoV-2 RNA in cerebellar tissue using the Centers for Disease MESHD Control and Prevention 2019-nCoV Real-Time Reverse Transcriptase-PCR Diagnostic Panel. On histopathology, necrotizing granulomas MESHD granulomas HP with numerous acid-fast bacilli were visualized, and Mycobacterium tuberculosis MESHD complex DNA was detected by PCR. Ventricular cerebrospinal fluid that day was negative for mycobacterial DNA. She had no known exposures to tuberculosis MESHD and no chest radiographic findings to suggest it. All 6 family members TRANS had normal chest radiographs and negative interferon-γ release assay results. The source of her tuberculous infection MESHD was not identified, and further investigations by the local health department were not possible because of the State of Michigan-mandated lockdown for control of SARS-CoV-2 spread.Conclusion. The detection of SARS-CoV-2 RNA in cerebellar tissue and the demonstration of seroconversion in IgG and IgA assays was consistent with acute SARS-CoV-2 infection MESHD of the central nervous infection MESHD. However, the cause of death was brain MESHD herniation from her rapidly progressive central nervous system tuberculosis MESHD. SARS-CoV-2 may mask or worsen occult tuberculous infection MESHD infection with severe HP with severe or fatal consequences.

    Neurological Involvement of Coronavirus Disease MESHD 2019: A Systematic Review

    Authors: Malik Ghannam; Qasem Alshaer; Mustafa Al-Chalabi; Lara Zakarna; Jetter Robertson; Georgios Manousakis

    doi:10.21203/ Date: 2020-05-23 Source: ResearchSquare

    Background: In December 2019, unexplained cases of pneumonia MESHD pneumonia HP emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease MESHD 2019 (COVID-2019) outbreak, a pandemic. Although the most common presentations of COVID-19 are fever MESHD fever HP, cough MESHD cough HP and shortness of breath, several clinical observations indicate that COVID-19 does affect the central and peripheral nervous system.  Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 that were evident for neurological involvement.  Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age TRANS was 62.28 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n=40) had cerebrovascular insults, 28% (n=23) had neuromuscular disorders, 18.3% of the patients (n=15) had encephalitis MESHD encephalitis HP or encephalopathy HP, and 2.4% (n=2) presented with status epilepticus MESHD status epilepticus HP. Conclusions: Neurological manifestations of COVID-19 infection MESHD are not rare, especially large vessel stroke MESHD stroke HP, Guillain barre syndrome MESHD and meningoencephalitis MESHD. Moving forward, further studies are needed to clarify the prevalence SERO of the neurological complications of COVID-19, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.

    COVID-19 associated meningoencephalitis MESHD complicated with intracranial hemorrhage MESHD intracranial hemorrhage HP. A case report.

    Authors: Mohammad Alolama; Anas Rashid; Debora Garozzo

    doi:10.21203/ Date: 2020-05-10 Source: ResearchSquare

    Introduction: The Coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature.The case: we describe a case of a 36 years old Coronavirus-positive patient that was admitted on emergency MESHD basis; his clinical presentation included neurological symptoms such as drowsiness HP and mild confusion MESHD confusion HP. Imaging revealed findings consistent with meningoencephalitis MESHD complicated by intracerebral hematoma and subdural MESHD hematoma MESHD. The latter was surgically evacuated after it became chronic and evidence of Coronavirus was found in the fluid.  Conclusion: our experience confirms that neurological complications might be a likely event in COVID-19. Although uncommon, the possible occurrence of meningoencephalitis MESHD should be kept in mind by physicians involved in the management of COVID-19 patients. Early recognition of brain involvement may provide better prognosis, preventing evolution into intracerebral hemorrhagic events.

    Hemisensory paresthesia MESHD paresthesia HP as the initial symptom of a SARS-Coronavirus-2 infection MESHD. A Case report.

    Authors: Myriam Herrnberger; Nadine Durmazel; Frank Birklein

    doi:10.21203/ Date: 2020-04-30 Source: ResearchSquare

    Neurological symptoms might be associated with a Covid-19 infection MESHD. There are frequent reports in the last weeks. The neurological symptoms range from harmless side effects of a viral infection MESHD to meningoencephalitis MESHD and acute haemorrhagic necrotizing encephalopathy HP.Our patient reported burning MESHD headache MESHD headache HP and paresthesia MESHD paresthesia HP as the initial symptoms mainly without other signs of viral infection MESHD like cough MESHD cough HP or fever MESHD fever HP. Such an initial neurological presentation seems to be rare. Most cases have neurological symptoms which can be expected after severe systemic viral infections MESHD like fever MESHD fever HP associated headache MESHD headache HP. Many COVID-19 patients with mild disease MESHD are at home and the further course is unknown. Our case shows, that neurological symptoms can be the first manifestation of an COVID-19 disease MESHD. While restricted paraesthesia has been reported in SARS-CoV-2 infections MESHD, hemisymptoms have not been described as initial symptoms. 

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

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