Corpus overview


MeSH Disease

Human Phenotype


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    An Analysis Review, Detection Coronavirus Disease MESHD 2019 (COVID-19) based on Biosensor Application

    Authors: Norhana Arsad; Bakr Taha; Yousif Al Mashhadany

    id:10.20944/preprints202008.0597.v1 Date: 2020-08-27 Source:

    The global spread of coronavirus disease MESHD (COVID -19) worldwide has had a significant effect on social and economic growth. The contamination keeps on advancing quickly and eccentrically, representing a significant test to its recognition and conclusion. Coronaviruses are commonly recognized by seclusion from tests, regardless of whether natural or clinical, utilizing some atomic science procedures, which can take a few days. In this work an analytical review of virus transmission TRANS, methods of diagnosing COVID -19 using artificial intelligence techniques to classify images and types of biosensors. At long last, the deformities MESHD and points of interest of each kind of sensor are recognized and examined. This exploration gives an explanatory audit of the utilization of crown infection COVID-19 in 2019. Related examinations were led utilizing five dependable databases, for example, Science Direct, IEEE Xplore, Scopus, Web of Science, and PubMed. An acceptable investigation is remembered for this audit, which can be depended upon as a logical database to put resources into another technique for recognizing COIVD-19.

    Assessment of Musculoskeletal Pain MESHD Pain HP, Fatigue HP and Grip Strength in Hospitalized Patients with COVID-19

    Authors: Sansin Tuzun; Aslinur Keles; dilara okutan; Tugbay Yildiran; Deniz Palamar

    doi:10.21203/ Date: 2020-08-10 Source: ResearchSquare

    IMPORTANCE Coronavirus disease 2019 (COVID-19) is an emerging disease that was declared as a pandemic by WHO. Although there are many retrospective studies to present clinical aspects of the COVID-19, still the involvement of the musculoskeletal system has not been deeply investigated.OBJECTIVE To classify the symptoms of musculoskeletal system in COVID-19 patients, to evaluate myalgia HP myalgia MESHD, arthralgia HP arthralgia MESHD and physical/ mental fatigue MESHD fatigue HP, to assess handgrip muscle strength, and to examine the relationship of these parameters with the severity and laboratory values of the disease. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was performed at the IUC-Cerrahpaşa Pandemic Clinic. Hospitalized 150 adults TRANS with laboratory and radiological confirmation of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) according to WHO interim guidance were included in the study. Data were recorded from May 15,2020, to June 30, 2020.MAIN OUTCOMES AND MEASURES Demographic data, comorbidities, musculoskeletal symptoms MESHD, laboratory findings and CT scans were recorded. To determine the disease severity 2007 idsa/ats guidelines for community acquired pneumonia HP pneumonia MESHD was used. Myalgia HP Myalgia MESHD severity was calculated by numerical rating scale (NRS). Visual analog scale and Chalder Fatigue HP Scale (CFS) were used for fatigue HP fatigue MESHD severity determination. Handgrip strength (HGS) was measured by Jamar hand dynamometer.RESULTS 103 patients (68.7%) were nonsevere and 47 patients (31.3%) were severe. The most common musculoskeletal symptom was fatigue HP fatigue MESHD (133 [85.3%]), followed by myalgia HP myalgia MESHD (102 [68.0%]), arthralgia HP arthralgia MESHD (65 [43.3%]) and back pain HP back pain MESHD (33 [22.0%]). Arthralgia HP Arthralgia MESHD, which was mostly notable at wrist (25 [16.7%]), ankle (24 [16.0%]) and knee (23 [15.3%]) joints, showed significant correlation with disease severity. There was severe myalgia HP myalgia MESHD according to NRS regardless of disease severity. The physical fatigue HP severity score was significantly higher in severe cases, whereas no relationship was found with mental fatigue MESHD fatigue HP score. Female patients with severe infection HP infection MESHD had lower grip strength with a mean value of 18.26 kg (P= .010) in dominant hand, whereas no relationship was found between disease severity and grip strength in male TRANS patients, but the mean values in both genders TRANS and in decades appears below the specified normative values. Lactate dehydrogenase (LDH) level and lymphocyte count were significantly correlated with lower grip strength. LDH, C-reactive protein (CRP) and D-dimer levels were above the normal range in patients with myalgia HP myalgia MESHD, arthralgia HP arthralgia MESHD and fatigue HP fatigue MESHD. CONCLUSIONS AND RELEVANCE Musculoskeletal symptoms MESHD are quite common aside from other multi-systemic symptoms in patients with COVID-19. Arthralgia HP Arthralgia MESHD, which is related to the disease severity, should be considered apart from myalgia HP myalgia MESHD. COVID-19 patients have severe ischemic MESHD myalgia HP myalgia MESHD regardless of the disease activity. Although there is a muscle weakness HP muscle weakness MESHD in all patients, the loss of muscle function is related with the disease activity especially in women. Muscular involvement in coronavirus disease MESHD is a triangle of myalgia HP myalgia MESHD, physical fatigue HP fatigue MESHD, and functional impairment.

    Frequency and severity of Covid-19 in patients treated with biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) for inflammatory rheumatic disease MESHD. A case-control study

    Authors: Dr. Anne LOHSE; Dr. Marie BOSSERT; Dr. Ana-Maria BOZGAN; Charlotte BOURGOIN; Dr. Aline CHARPENTIER; Dr. Cerise GUILLOCHON; Dr. Julie KESSLER; Dr. Jean-Charles BALBLANC; Dr. Thierry CONROZIER

    doi:10.21203/ Date: 2020-07-29 Source: ResearchSquare

    The aim of the study was to assess the impact (frequency and severity) of Covid-19 on patients treated with biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) for inflammatory rheumatic disease MESHD and to compare it to a control group consisting of patients with musculoskeletal conditions MESHD not treated with bDMARDs.Patients and methods:A case control study in 200 outpatients with musculoskeletal conditions MESHD. 100 consecutive patients who have been treated with bDMARDs and 100 other consecutive patients who did not take bDMARDs were asked to complete a 15-item standardized questionnaire regarding demographic data. The following information was recorded: gender TRANS, age TRANS, weight, height, body mass index, professional activity, family status, total number of children TRANS and number of children TRANS under 18, rheumatic disease MESHD diagnosis, current treatment for rheumatism MESHD, type of containment, close contact TRANS with Covid-19 patients, Covid-19 symptoms, Covid-19 test result and hospitalization for Covid-19.Results:bDMARD patients mostly suffered from rheumatoid arthritis HP rheumatoid arthritis MESHD, or RA MESHD, (47%) and ankylosing spondylitis MESHD (42%). The most prescribed bDMARDs were TNFα inhibitors (57%), IL-6 blockers (12%) and JAK inhibitors (11%). The mean duration of the current biological treatment was 38.6 months. Patients from the control group were suffering chiefly from osteoarthritis HP osteoarthritis MESHD (45%) and RA MESHD (21%). Compared to the control group, patients treated with bDMARDs were 10 years younger (p<0.001), fewer were retired (56% versus 31%) and more were on sick or incapacity leave (6% versus 18%). During lockdown, they were more likely to be working from home or working short term (27% versus 9%). 18 patients from the bDMARDs group stopped biological treatment: one because of Covid-19 evidenced by PCR, 11 because of symptoms suggesting Covid- 19 and only six from fear of contracting the disease. 12 patients, including the one Sars-CoV-2 +, resumed their treatment after a few weeks of interruption. There was no severe Covid-19 infection MESHD in the bDMARDs group. Among the three patients from the control group who had contracted Covid-19, one developed a very severe disease.Conclusion :This case-control study did not show an increase in the frequency or severity of Covid-19 in subjects suffering from chronic inflammatory rheumatism MESHD treated with biotherapies. Larger-scale studies are necessary before affirming that biologics do not expose patients to an increased risk of disease and complications.

    Impact of the Covid-19 lockdown period on adult TRANS musculoskeletal injuries MESHD and surgical management: a retrospective monocentric study

    Authors: Vincent Crenn; Monia El Kinani; Guy Pietu; Leteve Marie; Mike Persigant; Cécile Toanen; Yoann Varenne; Nicolas Goffinet; Kevin Buffenoir; François Javaudin; Emmanuel Montassier

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background The coronavirus disease MESHD 2019 (COVID-19) pandemic has led to the worldwide implementation of unprecedented public protection measures. On the 17th of March, the French government announced a lockdown of the population for 8 weeks. This monocentric study assessed the impact of this lockdown on the musculoskeletal injuries MESHD treated at the emergency department as well as the surgical indications.Methods We carried out a retrospective study in the Emergency Department and the Surgery Department of Nantes University Hospital from 18 February to 11 May 2020. We collected data pertaining to the demographics, the mechanism, the type, the severity, and inter-hospital transfer for musculoskeletal injuries MESHD from our institution. We compared the four-week pre-lockdown period and the eight-week lockdown period divided into two four-week periods: early lockdown and late lockdown.Results There was a 52.1% decrease in musculoskeletal injuries MESHD among patients presenting to the Emergency Department between the pre-lockdown and the lockdown period (weekly incidence: 415.3 ± 44.2 vs. 198.5 ± 46.0, respectively, p < .001). The number of patients with surgical indications decreased by 33.4% (weekly incidence: 44.3 ± 3.8 vs. 28.5 ± 10.2, p = .048). The policy for inter-hospital transfers to private entities resulted in 64 transfers (29.4%) during the lockdown period. There was an increase in the incidence of surgical high severity trauma MESHD (Injury Severity Score > 16) between the pre-lockdown and the early lockdown period (2 (1.1%) vs. 7 (7.2%), respectively, p = .010) as well as between the pre-lockdown and the late lockdown period (2 (1.1%) vs. 10 (8.3%), respectively, p = .004). We observed a significant increase in the weekly emergency department patient admissions between the early and the late lockdown period (161.5 ± 22.9, 235.5 ± 27.7, respectively, p = .028).Conclusion A pronounced decrease in the incidence of musculoskeletal injuries MESHD was observed secondary to the lockdown measures, with emergency department patient admissions being halved and surgical indications being reduced by a third. The increase in musculoskeletal injuries MESHD during the late confinement period and the higher incidence of severe trauma MESHD highlights the importance of maintaining a functional trauma MESHD center organization with an inter-hospital transfer policy in case of a COVID-19 second wave lockdown.

    Continuous flexibility analysis of SARS-CoV-2 Spike MESHD prefusion structures

    Authors: Roberto Melero; Carlos Oscar S Sorzano; Brent Foster; Jose Luis Vilas; Marta Martinez; Roberto Marabini; Erney Ramirez-Aportela; Ruben Sanchez-Garcia; David Herreros; Laura del Cano; Patricia Losana; Yunior C. Fonseca-Reyna; Pablo Conesa; Daniel Wrapp; Pablo Chacon; Jason S. McLellan; Hemant D. Tagare; Jose Maria Carazo

    doi:10.1101/2020.07.08.191072 Date: 2020-07-08 Source: bioRxiv

    With the help of novel processing workflows and algorithms, we have obtained a better understanding of the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state. We have re-analyzed previous cryo-EM data combining 3D clustering approaches with ways to explore a continuous flexibility space based on 3D Principal Component Analysis. These advanced analyses revealed a concerted motion involving the receptor-binding domain (RBD), N-terminal domain (NTD), and subdomain 1 and 2 (SD1 & SD2) around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations MESHD. We show that in this dataset there are not well-defined, stable, spike conformations, but virtually a continuum of states moving in a concerted fashion. We obtained an improved resolution ensemble map with minimum bias, from which we model by flexible fitting the extremes of the change along the direction of maximal variance. Moreover, a high-resolution structure of a recently described biochemically stabilized form of the spike is shown to greatly reduce the dynamics observed for the wild-type spike. Our results provide new detailed avenues to potentially restrain the spike dynamics for structure-based drug and vaccine design and at the same time give a warning of the potential image processing classification instability of these complicated datasets, having a direct impact on the interpretability of the results.Competing Interest StatementThe authors have declared no competing interest.View Full Text

    Effect of COVID-19 Pandemic on Anxiety HP Anxiety MESHD in Rheumatology Patients Taking Immunosuppressive Drugs

    Authors: Tugba Izci Duran; Seyyid Bilal Acikgoz; Cemal Gurbuz; Aysegul Ucar; Gokhan Yavuzbilge; Metin Ozgen

    doi:10.21203/ Date: 2020-06-15 Source: ResearchSquare

    Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a public health emergency that is causing international concern. Patients with medical comorbidities are more likely to be infected MESHD and have a worse prognosis. The purpose of this study was to determine the prevalence SERO of anxiety HP anxiety MESHD due to COVID-19 pandemic in patients with rheumatic MESHD and musculoskeletal diseases MESHD ( RMDs MESHD) who used immunosuppressive drugs during the initial stage of the COVID-19 pandemic and to identify the risk and protective factors that cause anxiety HP anxiety MESHD.Methods: A total of 145 patients with RMDs MESHD aged TRANS ≥18 years who used regular immunosuppressive drugs and 95 healthy controls were included in the study. An anonymous survey comprising questions regarding the COVID-19 pandemic was used, and the Beck anxiety MESHD anxiety HP inventory (BAI) was used to measure the anxiety HP anxiety MESHD levels of participants. Additional information was collected such as demographic data, current RMDs MESHD, immunosuppressive drugs used, information and concerns about COVID-19, and the source of information about COVID-19.Results: About 42.1% patients reported that the epidemic caused concern due to the drug they were using, and 33.8% rated their concerns as moderate and severe. The BAI scores of patients and healthy controls were 4 (0-52) and 3 (0-18) respectively. According to the BAI scores, 16.5% patients had moderate to severe anxiety HP anxiety MESHD symptoms; and comparison of the groups showed that the anxiety HP anxiety MESHD level of the patient group was significantly higher (38.6% vs. 18.9%, p=0.001). Female TRANS had more anxiety HP anxiety MESHD symptoms in both groups (p<0.005). In addition, anxiety HP anxiety MESHD was lower in patients with higher education levels (p=0.039).Conclusion: It should be ensured that patients in the high-risk group are not provided false information, the patients are individually informed, and they trust the treatment team. Providing online or smartphone-based psychoeducation and psychological interventions may be considered for these patients with high anxiety HP anxiety MESHD levels.

    Inbetweening auto-animation via Fokker-Planck dynamics and thresholding

    Authors: Yuan Gao; Guangzhen Jin; Jian-Guo Liu

    id:2005.08858v1 Date: 2020-05-18 Source: arXiv

    We propose an equilibrium-driven deformation algorithm MESHD (EDDA) to simulate the inbetweening transformations starting from an initial image to an equilibrium image, which covers images varying from a greyscale type to a colorful type on plane or manifold. The algorithm is based on Fokker-Planck dynamics on manifold, which automatically cooperates positivity, unconditional stability, mass conservation law, exponentially convergence and also the manifold structure suggested by dataset. The thresholding scheme is adapted for the sharp interface dynamics and is used to achieve the finite time convergence. Using EDDA, three challenging examples, (I) facial aging process, (II) coronavirus disease MESHD 2019 (COVID-19) invading/treatment process, and (III) continental evolution process are conducted efficiently.

    City-scale dark fiber DAS measurements of infrastructure use during the COVID-19 pandemic

    Authors: Nathaniel J. Lindsey; Siyuan Yuan; Ariel Lellouch; Lucia Gualtieri; Thomas Lecocq; Biondo Biondi

    id:2005.04861v1 Date: 2020-05-11 Source: arXiv

    Throughout the recent COVID-19 pandemic when government officials around the world ordered citizens to quarantine inside their homes, real-time measurements about the use of roads, hospitals, grocery stores, and other public infrastructure became vital to accurately forecast viral infection MESHD rates and inform future government decisions. Although mobile phone locations provide some information about community-level activity, dense distributed geophysical sensing of ground motions across a city are more complete and also natively anonymous. In this paper, we demonstrate how fiber-optic Distributed Acoustic Sensing (DAS) connected to a telecommunication cable beneath Palo Alto, CA captured seismic and geodetic signals produced by vehicles during the COVID-19 pandemic outbreak and subsequent quarantine. We utilize DAS strain measurements of roadbed deformation MESHD caused by local cars and trucks in an automatic template matching detection algorithm to count the number of vehicles traveling TRANS per day over a two-month period around the timing of the San Francisco Bay Area shelter-in-place order. Using a segment of the optical fiber near a major grocery store on Sand Hill Road we find a 50% decrease in vehicle count immediately following the order, but data from near Stanford Hospital showed a far more subtle change due to on-going hospital activities. We compare the information derived from DAS measurements to other quarantine response metrics and find a strong correlation with the relative changes reported by Google and Apple using mobile phone data.

    Knowledge, Attitude and Practice towards COVID-19 among Patients with Musculoskeletal and Rheumatic Diseases MESHD in Nepal: A Web- based Cross-Sectional Study

    Authors: Dr. Binit Vaidya; Dr. Manisha Bhochhibhoya; Dr. Rikesh Baral; Dr. Shweta Nakarmi

    doi:10.21203/ Date: 2020-04-22 Source: ResearchSquare

    Introduction/objectives: The global health crisis created by Coronavirus Disease MESHD (COVID-19) can be a serious concern to rheumatologists. The relationship of rheumatic diseases MESHD, their therapies, and COVID-19 with multiple genuine and malicious information available online can influence the knowledge and attitude of rheumatic MESHD patients. This web-based google-form study was conducted to understand the knowledge, attitude and practices of rheumatologic patients towards COVID-19 in Nepal. Methodology: A web based cross-sectional study was conducted among the patients with rheumatic diseases MESHD. Modified version of questionnaire prepared by Zhong BL et al was used after consent. It was then translated in Nepali language for comprehensibility. The final questionnaire contained a total of 29 questions; 6 for demographic parameters, 12, 5 and 6 for knowledge, attitude and practice behaviors, respectively. Simple descriptive statistics describing the positive responses in each domain. Multiple linear regression analysis done to observe demographic variables associated with the knowledge, attitude and practice. Results: Among 380 participants, 63.2% were female TRANS. Most of the participants were aware of the clinical features of COVID-19 (91.6 %), 71.5% had positive attitude towards its control, some (31.5 %) thought that they had greater chance of getting COVID-19 than others and 18.9 % believed that the anti-rheumatic medications could increase their susceptibility to infection. Majority (> 94.7%) practiced preventive measures.Conclusions: Patients with rheumatic diseases MESHD were aware of the general clinical features, route of transmission TRANS and general preventive measures regarding COVID-19.

    Hydrogen Peroxide Vapor sterilization of N95 respirators for reuse

    Authors: Patrick Kenney; Benjamin K Chan; Kaitlyn Kortright; Margaret Cintron; Nancy Havill; Mark Russi; Jaqueline Epright; Lorraine Lee; Thomas Balcezak; Richard Martinello

    doi:10.1101/2020.03.24.20041087 Date: 2020-03-27 Source: medRxiv

    Abstract Reprocessing of used N95 respirators may ameliorate supply chain constraints during the COVID-19 pandemic and provide a higher filtration crisis alternative. The FDA Medical Countermeasures Initiative previously funded a study of HP vapor decontamination of respirators using a Clarus C system (Bioquell, Horsham, PA MESHD) which normally is used to fumigate hospital rooms. The process preserved respirator function, but it is unknown if HP vapor would be virucidal since respirators have porous fabric that may harbor virus. We evaluated the virucidal activity of HP vapor using a BQ-50 system (Bioquell, Horsham, PA MESHD) after inoculating 3M 1870 N95 respirators (3M, St. Paul, MN) with 3 aerosolized bacteriophage that are a reasonable proxy for SARS-CoV-2. Inoculation resulted in contamination of the respirator with 9.87e4 plaque forming units (PFU) of phage phi-6, 4.17e7 PFU of phage T7 and 1.35e7 PFU of phage T1. Respirators were reprocessed with BQ-50 with a long aeration phase to reduce HP vapors. Virucidal activity was measured by a standard plaquing assay prior to and after sterilization. A single HP vapor cycle resulted in complete eradication of phage from masks (limit of detection 10 PFU, lower than the infectious dose of the majority of respiratory viral pathogens). After 5 cycles, the respirators appeared similar to new with no deformity MESHD. Use of a Bioquell machine can be scaled to permit simultaneous sterilization of a large number of used but otherwise intact respirators. HP vapor reprocessing may ease shortages and provide a higher filtration crisis alternative to non-NIOSH masks.

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MeSH Disease
Human Phenotype

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