We report a case of acute myelitis MESHD myelitis HP in a patient infected with severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2). A 66-year-old man with coronavirus disease MESHD 2019 was admitted with acute flaccid paralysis MESHD paralysis HP of the bilateral lower limbs and urinary and bowel incontinence HP. All serum SERO microbiological test results were negative, except for SARS-CoV-2 nucleic acid testing. Clinical findings indicated post-infectious acute myelitis MESHD myelitis HP. He received treatment containing ganciclovir, lopinavir/ritonavir, moxifloxacin, dexamethasone, human immunoglobulin, and mecobalamin. With a diagnosis of post-infectious acute myelitis MESHD myelitis HP and comprehensive treatment, paralysis MESHD paralysis HP of the bilateral lower extremities ameliorated. After two negative novel coronavirus RNA nasopharyngeal swab tests, he was discharged and transferred to a designated hospital for isolation and rehabilitation therapy.