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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Acute Transverse Myelitis MESHD Myelitis HP After SARS-CoV-2 Infection MESHD: A Rare Complicated Case of Rapid Onset Paraplegia HP in a Male TRANS Veteran 

    Authors: Ebrahim Hazrati; Ramin Hamidi Farahani; Amir Nezami Asl; Hamze Shahali

    doi:10.21203/rs.3.rs-68798/v1 Date: 2020-08-30 Source: ResearchSquare

    Background: SARS-CoV-2 (COVID-19) is a new human pathogen, and currently, the world has been plagued by its pandemic and there are no specific treatment options, mostly affects the respiratory system, ranging from mild flu-like symptoms to severe acute r espiratory syndrome MESHD(SARS), but extra respiratory multi-systemic involvement has also been reported.Case presentation: A 63-yr-old Caucasian male TRANS veteran (retired army colonel), known case of controlled T ype 2 diabetes, MESHD c hronic renal failure MESHDand i schemic MESHDh eart disease, MESHD about 4 days after the onset of f lu-like syndrome MESHD(with no t rauma MESHDhistory) experienced loss of control over both lower limbs, absent sensation from the chest below with constipation HP onstipation MESHDand urinary retention HP. Due to world SARS-CoV-2 (COVID-19) outbreak, his nasopharyngeal specimen was tested for COVID-19 reverse transcription polymerase chain reaction (RT-PCR) and positive result obtained. Chest x-ray and HRCT suggested severe pulmonary involvement. Immediately, he was admitted at emergency ward, treated based national COVID-19 protocol and a series of diagnostic procedures were started up to find out the cause of his non-heterogeneous peripheral (spinal) neuromuscular manifestations. Brain CT scan and MRI were normal, but spinal MRI with gadolinium contrast agent showing extensive increased T2 signal involves central grey matter and dorsal columns, extension between C7 and T12 with linear sagittally oriented enhancement posteriorly within the cord in the mid and lower thoracic cord. The CSF specimen obtained from LP shown p leocytosis, MESHD positive RT-PCR for SARS-CoV-2 and elevated IgG index. Clinical presentations, MRI, CSF and laboratory findings, after ruled out the other numerous possible causes with specific methods, suggested the A cute Transverse Myelitis MESHD Myelitis HP (A TM) MESHD as a probably complication of COVID-19 i nfection. MESHD Intravenous methylprednisolone and then human immunoglobulin was added to treatment regimen. At the end, complete resolution of d ysaesthesia, urinary retention MESHD urinary retention HP and constipation HP onstipation MESHDwere achieved. After continuous and long respiratory and motor rehabilitation programs, he was discharged home asymptomatic TRANS. Conclusions: We believe that SARS-CoV-2 has a potential to produces different extra respiratory multi-systemic involvement as immune-mediated process and complexes, and this should be kept in mind whenever encounter a patient with acute onset of neurological manifestations, especially after m icrobial infections MESHDor vaccinations.

    Acute transverse myelitis MESHD myelitis HP in a HIV MESHD-positive patient with COVID-19

    Authors: Vitalie Lisnic; Victor Nemtan; Evghenia Hacina; Galina Topciu; Elena Manole; Majda M. Thurnher; Rüdiger von Kummer

    doi:10.21203/rs.3.rs-50901/v1 Date: 2020-07-29 Source: ResearchSquare

    Immunocompromised status keeps on being a challenge for a neurologist, especially in the context of the coronavirus disease MESHD – 19 (COVID-19) pandemic. We report a clinical case of a human-immunodeficiency virus MESHD immunodeficiency HP virus ( HIV MESHD) - positive patient who developed an acute transverse myelitis MESHD myelitis HP. Magnetic Resonance Imaging (MRI) examination showed longitudinally extensive spinal cord abnormality MESHD spinal cord abnormality HP, and laboratory tests confirmed SARS-CoV-2 infection MESHD. The patient responded to methylprednisolone pulse therapy and therapeutic plasma SERO exchange. No cases of HIV-positive MESHD patients with myelitis HP myelitis MESHD and COVID-19 has been reported yet.

    Neurological Manifestations and Complications of COVID-19: A Literature Review

    Authors: Imran Ahmad; Farooq Azam Rathore

    id:10.20944/preprints202004.0453.v1 Date: 2020-04-25 Source: Preprints.org

    The Coronavirus disease MESHD due to SARS-CoV-2 emerged in Wuhan city, China in December 2019 and rapidly spread more than 200 countries as a global health pandemic. There are more 3 million confirmed cases TRANS and around 207,000 fatalities. The primary manifestation is respiratory and cardiac but neurological manifestations are being reported in the literature as case reports and case series. The most common reported symptoms to include headache HP headache MESHD and dizziness MESHD followed by encephalopathy HP encephalopathy MESHD and delirium HP delirium MESHD. Among the complications noted are Cerebrovascular accident MESHD, Guillian barre syndrome, acute transverse myelitis MESHD myelitis HP, and acute encephalitis MESHD encephalitis HP. The most common peripheral manifestation was hyposmia HP. It is further noted that sometimes the neurological manifestations can precede the typical features like fever HP fever MESHD and cough HP cough MESHD and later on typical manifestations develop in these patients. Hence a high index of suspicion is required for timely diagnosis and isolation of cases to prevent the spread in neurology wards. We present a narrative review of the neurological manifestations and complications of COVID-19. Our aim is to update the neurologists and physicians working with suspected cases of COVID-19 about the possible neurological presentations and the probable neurological complications resulting from this novel virus infection MESHD.

    Acute myelitis HP myelitis MESHD after SARS-CoV-2 infection MESHD: a case report.

    Authors: Kang Zhao; Jucun Huang; Dan Dai; Yuwei Feng; Liming Liu; Shuke Nie

    doi:10.1101/2020.03.16.20035105 Date: 2020-03-18 Source: medRxiv

    We report a case of acute myelitis MESHD myelitis HP in a patient infected with severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2). A 66-year-old man with coronavirus disease MESHD 2019 was admitted with acute flaccid paralysis MESHD paralysis HP of the bilateral lower limbs and urinary and bowel incontinence HP bowel incontinence MESHD. All serum SERO microbiological test results were negative, except for SARS-CoV-2 nucleic acid testing. Clinical findings indicated post-infectious acute myelitis HP myelitis MESHD. He received treatment containing ganciclovir, lopinavir/ritonavir, moxifloxacin, dexamethasone, human immunoglobulin, and mecobalamin. With a diagnosis of post-infectious acute myelitis HP myelitis MESHD and comprehensive treatment, paralysis HP paralysis MESHD of the bilateral lower extremities ameliorated. After two negative novel coronavirus RNA nasopharyngeal swab tests, he was discharged and transferred to a designated hospital for isolation and rehabilitation therapy.

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