Corpus overview


Overview

MeSH Disease

Human Phenotype

Cough (1)


Transmission

Seroprevalence

antibody (1)

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    COVID-19 relapse with prolonged viral shedding up to 60 days or re-infection, in 3 frontline healthcare workers with recurrent symptoms and persistent SARS-CoV-2 PCR positivity in Ireland, a developing diagnostic challenge: A case report

    Authors: Jonathan McGrath; Tara McGinty; Maureen Lynch; Edel O'Regan; Dominic Natin; Peter O'Gorman; John S Lambert

    doi:10.21203/rs.3.rs-34532/v1 Date: 2020-06-09 Source: ResearchSquare

    Background:To date, the Corona Virus Disease-2019 (COVID-19) pandemic has resulted in more than 24,400 confirmed cases TRANS in Ireland, with more than 30% involving Healthcare Workers (HCW). As more staff become involved in the care of COVID-19 patients, many key clinical considerations remain uncertain, including the possibility of re- infection MESHD following initial illness, the clinical significance of prolonged viral shedding and the degree of protection conferred by development of anti- Severe Acute Respiratory Syndrome Coronavirus 2 MESHD ( SARS-CoV-2) antibodies SERO.We present 3 cases of COVID19-infected HCWs MESHD, each with distinct episodes of recurrent symptoms following initial resolution and with persistently positive SARS-CoV-2 PCR results, ranging up to 60 days post onset of illness. PCR results, cycle threshold (Ct) values and clinical assessment are provided to discuss the diagnostic difficulties in assessing relapsed COVID-19 infection MESHD, or re-infection with new virus following return to work. Case presentations: Patient 1,2 and 3 ( age TRANS range 25-36) tested positive for SARS-CoV-2 via rtPCR on oro/nasopharyngeal swab with initial Ct values of 21.72, 24.52 and 26.58 respectively, following presentation with respiratory symptoms. All completed 14 day periods of self-isolation with full resolution of symptoms. Each patient has a clinical role and was involved in the management of COVID-19 patients following return to work. Patient 1 was admitted to hospital 44 days after initial illness, with cough HP cough MESHD, dyspnoea and a concurrent diagnosis of neurosyphilis MESHD. SARS-CoV-2 PCR was positive with Ct value 31.36 and remained positive for at least 60 days following initial illness onset. A full clinical recovery followed. Patients 2 and 3 represented to the Emergency Department with recurrent respiratory symptoms 29 and 40 days following initial illness onset respectively. SARS-CoV-2 PCR was demonstrated in each with Ct values 31.16 and 30.72 respectively. Each subsequently made a full recovery following a second period of self-isolation. Anti-SARS-CoV-2 IgG was demonstrated in all 3 patients. Conclusions: These cases demonstrate the diagnostic difficulties in determining intermittent presentation of COVID-19 infection MESHD with prolonged viral shedding, or re-infection with new virus following return to work.  As the pandemic progresses, this represents a growing diagnostic challenge impacting patient assessment, staff deployment following illness and infection control. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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