Corpus overview


MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus



There are no seroprevalence terms in the subcorpus

    displaying 1 - 2 records in total 2
    records per page

    SeXX and COVID-19: Tussle between the Two

    Authors: Ashlesh Patil; Jaya Prasad Tripathy; Vishwajit Deshmukh; Bharat Sontakke; Satyendra C. Tripathi

    id:10.20944/preprints202006.0159.v1 Date: 2020-06-14 Source:

    Novel coronavirus disease MESHD (COVID-19) has affected nearly 7 million individuals and claimed more than 0.4 million lives to date. There are several reports of gender TRANS differences related to infection MESHD and death MESHD due to COVID-19. This raises important questions such as “Whether there are differences based on gender TRANS in risk and severity of infection MESHD or mortality rate?” and “What are the biological explanation and mechanisms underlying these differences?” Emerging evidence has proposed sex-based immunological, genetic, and hormonal differences to explain this ambiguity. Besides biological differences, women have also faced social inequities and economic hardships due to this pandemic. Several recent studies have shown that independent of age TRANS males TRANS are at higher risk for severity and mortality in COVID-19 patients. Although susceptibility to SARS-CoV-2 was found to be similar across both genders TRANS in several disease MESHD cohorts, a disproportionate death MESHD ratio in men can be partly explained by the higher burden of pre-existing diseases and occupational MESHD exposures among men. From an immunological point of view, females TRANS can engage a more active immune response, which may protect them and counter infectious diseases MESHD as compared to men. This attribute of better immune responses towards pathogens is thought to be due to high estrogen levels in females TRANS. Here we review the current knowledge about sex differences in susceptibility, the severity of infection MESHD and mortality, host immune responses, and the role of sex hormones in COVID-19 disease MESHD.

    COVID-19 Global Pandemic Planning: Decontamination and Reuse Processes for N95 Respirators

    Authors: Douglas Jay Perkins; Steven Villescas; Terry H Wu; Timothy B Muller; Steven Bradfute; Ivy Foo-Hurwitz; Qiuying Cheng; Hannah Wilcox; Myissa Weiss; Chris Bartlett; Jens Langsjoen; Phil Seidenberg

    doi:10.1101/2020.04.09.20060129 Date: 2020-04-14 Source: medRxiv

    Coronavirus disease MESHD 2019 (COVID-19) is an illness caused by a novel coronavirus, severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2). The disease MESHD was first identified as a cluster of respiratory illness in Wuhan City, Hubei Province, China in December 2019, and has rapidly spread across the globe to greater than 200 countries. Healthcare providers are at an increased risk for contracting the disease due to occupational MESHD exposure and require appropriate personal protective equipment (PPE), including N95 respirators. The rapid worldwide spread of high numbers of COVID-19 cases has facilitated the need for a substantial supply of PPE that is largely unavailable in many settings, thereby creating critical shortages. Creative solutions for the decontamination and safe reuse of PPE to protect our frontline healthcare personnel are essential. Here, we describe the development of a process that began in late February 2020 for selecting and implementing the use of hydrogen peroxide vapor (HPV) as viable method to reprocess N95 respirators. Since pre-existing HPV decontamination chambers were not available, we optimized the sterilization process in an operating room after experiencing initial challenges in other environments. Details are provided about the prioritization and implementation of processes for collection and storage, pre-processing, HPV decontamination, and post-processing of filtering facepiece respirators (FFRs). Important lessons learned from this experience include, developing an adequate reserve of PPE for effective reprocessing and distribution, and identifying a suitable location with optimal environmental controls (i.e., operating room). Collectively, information presented here provides a framework for other institutions considering decontamination procedures for N95 respirators.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.