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SARS-CoV-2 proteins

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    Features and outcomes of secondary sepsis MESHD and urinary tract infections in COVID-19 MESHD patients treated with stem cell nebulization

    Authors: Gina Marcela Torres Zambrano; Rene Antonio Rivero; Carlos Villegas Valverde; Yendry Ventura Carmenate

    doi:10.1101/2020.12.05.20244483 Date: 2020-12-07 Source: medRxiv

    Background COVID-19 MESHD is the defining global crisis of our time. Secondary complication such as urinary tract infections and sepsis MESHD, worsen the already established problem, creating a new challenge. ObjectiveTo characterize the features and outcomes in COVID-19 MESHD patients with sepsis MESHD and urinary tract infection MESHD. MethodsAn observational and analytical study was conducted within the framework of the SENTAD COVID clinical trial at the Abu Dhabi Stem Cells Center, were the patients received a nebulization therapy with the use of autologous stem cells (group A). Those patients were compared with a not stem cells treated control arm (group B), and both received the UAE COVID 19 standard management. An analysis of the culture samples, antimicrobial agents and the efficacy of the therapy on patients outcomes was done. ResultsA significant difference between the groups was found in the UTI incidence (p=*0.0206). Patients in group A showed a lower tendency to sepsis MESHD in comparison with group B (7% vs 21%), HR=0.35, (95% Confidence Interval: 0.13 - 0.91), p=0.0175. It was calculated a NNT=7.3. Candida albicans was the most frequently agent causing sepsis MESHD and UTI. The massive use of broad-spectrum antimicrobials was striking. ConclusionsWe found a protective factor of stem cells against secondary infection in COVID 19 cases, in terms of sepsis MESHD and UTI. The suggested immunomodulatory effect of stem cells offers a therapeutic strategy to manage the disease and avoid several complications. Antimicrobial agents can lead to increased opportunistic infections MESHD, so a rational approach to these treatments must be considered.

    A Case Report of Prolonged COVID-19 MESHD Positive RT-PCR for five months

    Authors: Zeinab Siami; Alireza Soleimani; Armin Khavandegar

    doi:10.21203/rs.3.rs-97733/v1 Date: 2020-10-24 Source: ResearchSquare

    Background: The COViD-19 MESHD gold standard assessment tool remained the RT-PCR of upper respiratory tract specimen extracted by the nasopharyngeal swab. A positive result would dwindle through a three-week course and, eventually, would be undetectable. The most prolonged period of detectable viral RNA was 37 days. Besides, COViD-19 MESHD RT-PCR remained positive for 74 days in a patient suffering from lymphoma MESHD Case presentation: In this study, we have presented a 56-year-old Persian male patient, a known case of lymphoma MESHD since 2015, who experiences many episodes of chemotherapy with a five-month positive RT-PCR COViD-19 MESHD laboratory test and finally was intubated and then died of opportunistic pulmonary infections MESHD. Conclusion: COViD-19 MESHD patients who have concurrent lymphoma MESHD failed to remove the virus thoroughly, despite providing appropriate treatment regimens.

    Health systems trust in the time of Covid-19 MESHD Covid-19 MESHD pandemic in Bangladesh: A qualitative exploration

    Authors: Taufique Joarder; Muhammad Nahian Bin Khaled; Shahaduz Zaman

    doi:10.1101/2020.08.05.20157768 Date: 2020-08-06 Source: medRxiv

    Background: Lack of trust hinders care seeking, and limits community support for contact tracing, care seeking, information and communication uptake, multisectoral or multi-stakeholder engagement, and community participation. We aimed at exploring how trust might be breached and what implications this may have in COVID-19 MESHD COVID-19 MESHD pandemic response by the Bangladesh health systems. Methods: We conducted this qualitative research during the pandemic, through seven online focus group discussions, with purposively selected mixed-gender groups of clinicians and non-clinicians (n=50). Data were analyzed through conventional content analysis method. Results: The common thread throughout the findings was the pervasive mistrust of the people in Bangladeshi health systems in its management of COVID-19 pandemic MESHD. In addition to the existing health systems weaknesses, few others became evident throughout the progression of the pandemic, namely, the lack of coordination challenges during the preparatory phase as well as the advanced stages of the pandemic. This; compounded by the health systems and political leadership failures MESHD, lead to opportunistic corruption MESHD and lack of regulations; leading to low quality, discriminatory, or no service at all. These have trust implications, manifested in health seeking from unqualified providers, non-adherence to health advice, tension between the service seekers and providers, disapproval of the governance mechanism, misuse of already scarce resources, disinterest in community participation, and eventually loss of life and economy. Conclusions: Health sector stewards should learn the lessons from other countries, ensure multisectoral engagement involving the community and political forces, and empower the public health experts to organize and consolidate a concerted health systems effort in gaining trust in the short run, and building a resilient and responsive health system in the long.

    Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses

    Authors: Sui-Yuan Chang; Kuo-Yen Huang; Tai-Ling Chao; Han-Chieh Kao; Yu-Hao Pang; Lin Lu; Chun-Lun Chiu; Hsin-Chang Huang; Ting-Jen Rachel Cheng; Jim-Min Fang; Pan-Chyr Yang

    doi:10.21203/rs.3.rs-52066/v1 Date: 2020-08-01 Source: ResearchSquare

    A metal nanoparticle composite TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 can inhibit six major clades of SARS-CoV-2 with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike PROTEIN proteins to ACE2 HGNC receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and Tamiflu-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections MESHD.

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