Corpus overview


MeSH Disease

Pain (28)

Infections (12)

Fever (8)

Cough (8)

Disease (8)

Human Phenotype

Pain (25)

Fever (8)

Cough (8)

Fatigue (5)

Anosmia (4)


    displaying 1 - 10 records in total 28
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    Paracetamol use in COVID-19: friend TRANS or enemy?

    Authors: Piero Sestili; Carmela Fimognari

    id:202008.0186/v1 Date: 2020-08-07 Source:

    COVID-19 pandemic represents an unprecedented sanitary threat: antiviral and host-directed medications to treat the disease MESHD are still urgently needed.A great effort has been paid to find drugs and treatments for hospitalized, severely ill patients. However, medications used for the domiciliary management of initial symptoms, notwithstanding their importance, have not been and are not presently regarded with the same attention. In analogy with other respiratory viral infections MESHD, COVID-19 patients in the early phase require specific antivirals (still lacking) and non-etiotropic drugs to lower pain MESHD pain HP, fever MESHD fever HP and control inflammation MESHD. Non-steroidal antinflammatory drugs (NSAIDs) and paracetamol (PAC) are widely used as non-etiotropic agents in these conditions and hence are both theoretically repurposable for COVID-19. However, a warning from some research reports and National Authorities raised NSAIDs safety concerns because of the supposed induction of ACE2 protein levels (the receptor used by SARS-CoV2 to enter host airways cells), the risk of bacterial superinfections MESHD and masking of disease MESHD symptoms. As a consequence, the use of NSAIDs was, and is, strongly discouraged while the alternative adoption of paracetamol is still preferred.On the basis of novel data and hypothesis on the possible role of scarce glutathione (GSH) levels in the exacerbation of COVID-19 and of the GSH depleting activity of PAC, this commentary raises the question of whether PAC may produce an oxidative imbalance which could be detrimental in COVID-19 clinical outcomes.

    Associations between personal protective equipment and nursing staff stress during the COVID-19 pandemic

    Authors: Manuela Hoedl; Doris Eglseer; Silvia Bauer

    doi:10.1101/2020.08.06.20164129 Date: 2020-08-07 Source: medRxiv

    Background: The results of several projects on the effects of personal protective equipment (PPE) have been published since the outbreak of COVID-19. It is known that wearing PPE, and specifically face masks, has physcial consequences like headache MESHD headache HP and pain MESHD pain HP, which can increase stress among nursing staff. However, none of these studies placed a focus on PPE and nursing staff, although nurses are the only members of the health care profession who are at the patients bedsides 24/7, and PPE is the only way to protect them from a COVID-19 infection MESHD. Therefore, this study was carried out to investigate the association between the use of PPE and stress among nursing staff during the COVID-19 pandemic. Methods An online, cross-sectional survey was conducted, which we distributed using snowball sampling techniques. The questionnaire was developed on the basis of (inter-)national recommendations as well as the international literature. We used the perceived level of stress scale to measure the nursing staff members stress levels. Results We included data collected from 2600 nurses in this analysis. Nearly all nursing staff wore face masks. We showed that more than two-thirds of the nurses had moderate to high levels of stress. No statistically significant association between the use of PPE and stress was detected. However, we show a statistically significant association between the duration of mask usage and stress. Discussion and conclusions Nearly all participating nurses wore face masks or FFP masks to protect themselves from COVID-19 infection MESHD. This observation might indicate that Austrian nurses display a high level of compliance with national and international regulations and play a key role in such pandemics. Our results also show that increased mask-wearing time led to increased stress levels. These results suggest that (inter-)national regulations on how and when to use PPE should include a maximum duration of time for wearing each type of mask. Such regulations could help to prevent work-related stress, particularly in the case of future epidemics, and avoid burnout among nursing staff or even nurses leaving their jobs. The consequences of both of these negative outcomes should be considered in light of the predicted expected future shortage of health care workers.

    Infected hip prosthesis in patient with suspected Covid-19 infection MESHD

    Authors: Dr. Andrea Cosentino; Dr. Gianni Odorizzi; Dr. Wilhelm Berger

    doi:10.21203/ Date: 2020-08-03 Source: ResearchSquare

    Background: Infections MESHD following arthroplasty are one of the major risks during this type of surgery.Case presentation: Four and half years after right hip arthroplasty surgery, the patient came back to our attention with pain MESHD pain HP at the same hip. The instrumental examinations showed signs of cup detachment and therefore, after carefully analyzing the case, we decided to perform a sterile aspiration HP of the hip in the operating room under C-arm fluoroscopy. Microbiological examinations showed positivity for E.Coli. The patient underwent to surgery to remove the prosthesis and implant a spacer. A therapy with Cefotaxim 2g 1-1-1 for 6 weeks was then set, after which a total arthroplasty was implanted. During this period, the Covid-19 pandemic occurred and therefore the patient performed two nasal-throat swabs, both negative. However, one week after the final surgery, respiratory conditions worsened and we performed a chest X-ray and CT scan, with suggestive images of ground-glass opacification patterns (GGO). Due to the clinic and the characteristic images of the instrumental examinations, the patient was transferred to the observation ward, waiting for the response of two additional swabs, also negative. The patient was then transferred to the ward for patients with typical symptoms of Covid-19 but with negative swabs for two weeks and subsequently discharged at home.Conclusion: Despite the concomitant Covid-19 pandemic, the guidelines in case of periprosthetic hip infection MESHD infection further confirm TRANS further confirm the correct management of the patient. 

    Sexual Function, Mental Health, and Quality of Life Under Strain of COVID-19 Pandemic in Iranian Pregnant and Lactating Women: A Cross-sectional Study

    Authors: Negin Mirzaei; shahideh Jahanian Sadatmahalleh; Mahnaz Bahri Khomami; Ashraf Moini; Anoshirvan Kazemnejad

    doi:10.21203/ Date: 2020-08-03 Source: ResearchSquare

    Background The impact of COVID-19 pandemic on mental health of pregnant and lactating women is unclear. This study aimed to assess the impact of COVID-19 on psychological health, sexual function, and quality of life (QoL) in Iranian pregnant and lactating women and compare the results with non-pregnant /lactating (as the control group).Method: This cross-sectional study was carried out on pregnant and lactating women as case groups, with non-pregnant /lactating women as control. Patients were asked to complete three questionnaires: Hospital Anxiety HP and Depression Scale (HADS), Female TRANS Sexual Function Index (FSFI), and Short-Form Health Survey (SF-12). One-way ANOVA was used to reveal the statistical differences between the three groups.Result The mean age TRANS of patients was 20.81 ± 5.92 years old. Evaluation of the three groups with regard to HADS and SF-12 showed that all mean values were lower in pregnant women than in other groups. Also, the differences in scores in the three groups were statistically significant (P˂0.001). The comparison of FSFI scores showed that the mean of all domain and total scores were significantly lower in pregnant women compared with other groups. The differences between the three groups were statistically significant during desire, arousal, orgasm, pain MESHD pain HP, and total score (P˂0.001).Conclusion The COVID-19 epidemic increases the risk of depression, anxiety HP, FSD, and lowers QoL in pregnant and lactating women, with the general population. This suggests the urgent need for psychological intervention in the maternal population during the epidemic.

    The volume of general surgery emergency MESHD cases in a government hospital during the COVID -19 pandemic and two other periods: A comparative study

    Authors: Ibrahim abu shakra; Maxim Bez; Samer Ganam; Rula Francis; Amir Muati; Amitai Bickel; Fahed Merei; Ziv Talmi; Khatib Kamal; Eli Kakiashvili

    doi:10.21203/ Date: 2020-07-27 Source: ResearchSquare

    Objective We compared characteristics of patients admitted to a northern Israeli hospital with common surgical complaints during three periods: the lockdown due to the COVID-19 outbreak, the Second Lebanon War in 2006, and a regular period.Background During March and April 2020, reductions in non-COVID-19 hospital admissions were observed around the world. Elective surgeries, visits with general practitioners, and diagnoses of medical emergencies MESHD were consequently delayed.Methods Demographic, medical, laboratory, imaging, intraoperative, and pathological data were collected from electronic medical files of patients who received emergency MESHD treatment at the surgery department of a single hospital in northern Israel. We compared characteristics of patients who were admitted with various conditions during three periods.Results Patients’ mean age TRANS and most of the clinical parameters assessed were similar between the periods. However, pain MESHD pain HP was reportedly higher during the COVID-19 than the control period (8.7 vs. 6.4 on a 10-point visual analog scale, P < 0.0001). During the COVID-19 outbreak, the Second Lebanon War, and the regular period, the mean numbers of patients admitted daily were 1.4, 4.4, and 3.0, respectively. The respective mean times from the onset of symptoms TRANS until admission were 3, 1, and 1.5 days, P < 0.001. The respective proportions of surgical interventions for appendiceal disease MESHD were 95%, 96%, and 69%; P = 0.03.Conclusion Compared to a routine period, patients during the COVID-19 outbreak waited longer before turning to hospitalization, and reported more pain MESHD pain HP at arrival. Patients during both emergency MESHD periods were more often treated surgically than non-operatively.

    In silico study of SARS-CoV-2 Nucleocapsid Protein-Protein Interactions and Potential Candidates for their Stabilization

    Authors: Martin Lavecchia; Julian Fernandez

    id:10.20944/preprints202007.0558.v1 Date: 2020-07-23 Source:

    The outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19, has caused a global health crisis. Unfortunately, only a few treatments have proved to be effective, and their worldwide distribution remains as a challenge. Due to the urgency of the situation, drug repurposing remains as the fastest way to identify possible therapeutic options. Recent studies have shown that the stabilization of non-native Protein-Protein Interactions (PPIs) of the nucleocapsid protein of MERS coronavirus is a valid strategy to inhibit viral replication, but no study up to date has been done in SARS-CoV-2. In this work, a novel protocol for the discovery of PPIs stabilizers is presented and applied to SARS-CoV-2 N protein with a drug repurposing approach. This enabled us to identify that catechin, a structural motif present in widely distributed natural products, might be a privileged scaffold for this type of stabilization. Since many of the compounds presented in this work are generally considered nutraceuticals and have also been exhaustively studied, even though some of them contain PAINS MESHD PAINS HP substructures, could be good candidates for the SARS-CoV-2 nucleocapsid inhibition and be considered for further in vitro testing against COVID-19.

    Comparison of Acute Appendicitis MESHD Before and Within COVID 19 Era: A Retrospective Study from Rural Nepal

    Authors: Suman Baral; Rajkumar Chhetri; Neeraj Thapa

    doi:10.21203/ Date: 2020-07-22 Source: ResearchSquare

    Background Currently, the world has been engulfed with the pandemicity of the novel severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) and various mitigating measures like lock down and social distancing are being taken which have created significant impact in the emergency MESHD surgical health delivery including acute appendicitis MESHD (AA). The main aim of this study was to compare the demographic and clinical parameters between two cohorts before the onset of lockdown and within the pandemic.Methods A retrospective cohort analysis was performed between two groups of patients presenting with AA in one of the tertiary care centers of rural Nepal. The cohorts were named group A and group B who presented three months prior to and after initiation of lockdown on March 24 2020 respectively. These two groups of patients were compared in demographics, clinicopathological characteristics and surgical aspects of acute appendicitis MESHD. Results There were 42 patients in group A and 50 patients in group B. Mean age TRANS of the patients was 31.32±171.18 years with male TRANS preponderance in group B (N= 29). Mean duration of pain MESHD pain HP increased significantly in group B [55.4±25.9(B) vs 43.52±30.3(A) hours, P= 0.04] along with mean duration of surgery. [51.06±9.4(B) vs 45.27±11.8(A) minutes, P= 0.015] There was significant decrease in post-operative hospital stay among group B patients. [3.05±1.19(B) vs 4.05±0.8(A) days, P= 0.0001] Complicated cases increased in group B (38% vs 33.3 % including appendicular perforation in 10 cases with perforation rate of 20 %. Six of these 10 cohorts had fecalith present intraoperatively. (P= 0.0001) Similarly, mean duration of presentation to hospital significantly increased in group B patients with perforation. [64.8±22.7(B) vs 52.05±14.7(A) hours]    Conclusion During the adversity of COVID 19, increased number of cases of AA can be dealt with surgery as the chances of late presentation and complexity of the lesion exists.

    High prevalence SERO of SARS-CoV-2 Infection MESHD Among Symptomatic Healthcare Workers in a large university tertiary hospital in São Paulo, Brazil

    Authors: Carolina Palamin Buonafine; Beatriz Nobre Monteiro Paiatto; Fabyano Leal; Samantha Matos; Camila Ohomoto Moraes; Giovanna Guazzelli Guerra; Marcus Vinicius Vidal Martuchelli; Danielle Leal Oliveira; Edison Luiz Durigon; Camila Pereira Soares; Erika Donizette Candido; Bruna Larotonda Telezynski; Marco Aurelio Safadi; Flavia Jacqueline Almeida

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection MESHD, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection MESHD are of paramount importance to inform screening strategies and infection MESHD control practices in this scenario. The aims of this study were to investigate the prevalence SERO and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence SERO of SARS-CoV-2 infection MESHD among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age TRANS was 34.2 ( 9.9) years and 205 (69.5%) were female TRANS. We did not find significant differences in the prevalence SERO of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection MESHD. After multivariate analysis, using logistic regression, anosmia HP (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain HP pain MESHD (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection MESHD. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male TRANS) and 2 (1.6%) died.Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection MESHD among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia HP and ocular pain HP pain MESHD were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

    Mental health, attitudes, and behavior of healthcare workers amid Covid-19 pandemic

    Authors: Ercan Kurt; İbrahim Ethem Ovalı; Hakan Tibilli; Umut Gulacti; Hakan Kaya; Mehtap Koparal; Ugur Lok; Semih Canpolat; Esra Kurt Canpolat; Fatih Doğan; Abdulmecit Afsin; Safiye Kafadar; Şeyho Cem Yucetas; Hüseyin Kafadar

    doi:10.21203/ Date: 2020-07-03 Source: ResearchSquare

    Objective: To evaluate the mental Health and Psychosocial status, thoughts about the measures taken by the government, attitudes, and behaviors of HCWs facing the Covid-19 pandemic.Methods: A 56-question multiple-choice survey was performed by a one-to-one interview with the HCWs in 3 registered hospitals fighting the Covid-19 pandemic from 20 May to 10 June 2020. Mental health variables were assessed via the Patient Health Questionnaire-4 (PHQ-4) and the Turkish Beck Depression Scale to specify psychological manifestations. A scoring system was applied using a four-point Likert scale, from no points (“strongly disagree”) to three points (“strongly agree”) to determine the levels of anxiety HP and depression.Results: A total of 300 HCWs (45 physicians, 255 non-physician health care workers) enrolled in the survey. Only 0.8% of HCWs took psychological support from a therapist or psychiatrist. The most common concern about Covid-19 pandemic was that “the elderly TRANS and other risky population was being infected” (37.9%). 89.2% HCWs who felt the concern was that they had changed their thoughts with the information they got from television (P= 0.005, χ2= 20.271). Compared with non-physician HCWs, the physicians about the spreading of the Covid- 19 felt more the concern (%80 vs %47.1, p= 0.006 χ2=12.591) and physicians higher rate agreed that the number of tests being performed was sufficient enough. (53.3% vs. 41.2%, p=0.030, OR:0.29-0.35, χ2: 7.047),  For all HCWs, the "feeling of being infected with Covid-19” item had the highest mean total score (2.60 ± 0.97). The mean score of “feeling nervous/anxious/on edge” item was 2.53±0.52 for physicians, and 2.26±0.86 for non-physician HCWs. Non-physicians HCWs had a higher mean score for “Feeling of increased body pain MESHD pain HP and agony” item than physicians (0.27±0.80 vs 0.76±1.23; mean dif= -0.50, 95% confidence interval=-1.002 to 0.006, p<0.05).Conclusions:The results of this survey study showed that the highest anxiety HP score for all healthcare professionals was the “feeling of being infected with covid-19”. Both physicians and non-physicians HCWs were feeling nervous/anxious/on edge largely according to anxiety HP scores.

    Symptomatology of Coronavirus Disease MESHD 2019 (COVID-19) - Lessons from A Meta-Analysis Across 13 Countries

    Authors: Champika Saman Kumara Gamakaranage; Dineshani Hettiarachchi; Dileepa Ediriweera; Saroj Jayasinghe

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians.Objective: The objective of the study was to identify symptoms and their frequencies of coronavirus disease MESHD 2019 with a meta-analysis of studies from several countries. Data sources: A systematic review using PubMed and Google Scholar data sources and reference tracing TRANS were used to identify 7176 relevant articles. Eligibility criteria: Suitable articles were selected manually with selection criteria and 14 original articles included for meta-analysis. Data abstraction analysis: PRISMA guideline was used for abstracting data. Then a table was generated by feeding it with numbers and proportions of each symptom described in original studies. A meta-analysis was carried out using random effect models on each symptom separately across the studies and their prevalence SERO rates and 95% confident intervals calculated.Results: We identified 14 relevant scientific papers, either cross-sectional or cohort studies and analyzed. There were 2,660 cases of COVID-19. he majority were from China (n=2,439, 91.7%) and remainder from the Netherlands, Italy, Korea and India and one article from Europe. There was a total of 32 symptoms (i.e. present in >50% of patients): fever (79.56%, 95% CI: 72.17-86.09%), malaise (63.3%, 95% CI: 53.1 – 73.0%), cough MESHD cough HP (56.7. %, 95% CI: 48.6 - 64.6 %) and cold (55.6%, 95% CI: 45.2 – 65.7%). Symptoms of intermediate incidence (5-49%) were; anosmia HP, sneezing MESHD sneezing HP, ocular pain HP pain MESHD, fatigue MESHD fatigue HP, sputum production, arthralgia MESHD arthralgia HP, tachypnea MESHD tachypnea HP, palpitation HP, headache MESHD headache HP, chest tightness HP, shortness of breath, chills MESHD chills HP, myalgia MESHD myalgia HP, sore throat, anorexia MESHD anorexia HP, weakness, diarrhea MESHD diarrhea HP, rhinorrhea HP, dizziness MESHD, nausea MESHD nausea HP, altered level of consciousness, vomiting MESHD vomiting HP and abdominal pain MESHD abdominal pain HP. Rare symptoms (<5% of patients) were: tonsil swelling, haemoptysis, conjunctival injection, lymphadenopathy MESHD lymphadenopathy HP and rash were uncommon symptoms of coronavirus disease MESHD (<5%).Conclusion and implications of key findings: We found (25/32) symptoms to be present in =>5% of cases which could be considered as “typical” symptoms of COVID-19. The list of symptoms we identified are different from those documents released by the WHO, CDC, NHS, Chinese CDC, Institute Pasteur and Mayo Clinic. The compiled list would be useful for future researchers to document a comprehensive picture of the illness.

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MeSH Disease
Human Phenotype

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