Background: COVID-19 (Corona virus Disease MESHD-2019) is a new public health emergency MESHD and is a pandemic currently. Incidence and mortality of COVID-19 vary in different geographical areas. In this study we aimed to analyse the relationship between malaria MESHD transmission TRANS and BCG vaccination with COVID-19 incidence in the world map. Materials and methods: We collected malaria MESHD cases data (World Health Organisation (WHO), 2018), worldwide COVID-19 cases and mortality data (European Centre for Disease MESHD Prevention and Control) and data on BCG vaccination. COVID-19 incidence and mortality was compared. Findings: Data on 5316978938 persons from 166 countries were analysed. Malaria MESHD incidence rate was negatively correlated with COVID-19 incidence rate (correlation coefficient = -0.513, p<0.001). Malaria MESHD free countries had significantly higher number of COVID-19 cases compared to malaria MESHD endemic countries. In Europe and Americas, countries, which have higher BCG vaccination coverage, had significantly less mortality per thousand population compared to those with low BCG coverage (median 0.0002 (0-0.0005) vs 0.0029 (0.0002-0.0177), p=0.017). The case fatality ratio of COVID-19 was related nonlinearly to the malaria MESHD incidence. Conclusions: The results suggest the changing human immune system as we progress to eliminate parasitic diseases MESHD with time. Chloroquine exposure in malaria MESHD endemic zones might have a protective effect.