Corpus overview


Overview

MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


Transmission

There are no transmission terms in the subcorpus


Seroprevalence
    displaying 1 - 1 records in total 1
    records per page




    Exosomal microRNAs Drive Thrombosis MESHD in COVID-19

    Authors: Jessica Gambardella; Celestino Sardu; Marco Bruno Morelli; Vincenzo Messina; Vanessa Castellanos; Raffaele Marfella; Paolo Maggi; Giuseppe Paolisso; Xujun Wang; Gaetano Santulli

    doi:10.1101/2020.06.16.20133256 Date: 2020-06-18 Source: medRxiv

    Thrombotic and thromboembolic complications have been shown to play a critical role in the clinical outcome of COVID-19. Emerging evidence has shown that exosomal miRNAs are functionally involved in a number of physiologic and pathologic processes MESHD. However, neither exosomes nor miRNAs have been hitherto investigated in COVID-19. To test the hypothesis that exosomal miRNAs are a key determinant of thrombosis MESHD in COVID-19, we enrolled patients positive for COVID-19. Circulating exosomes were isolated from equal amounts of serum SERO and levels of exosomal miRNAs were quantified. We divided our population in two groups based on the serum SERO level of D-dimer on admission. Strikingly, we found that exosomal miR-424 was significantly upregulated whereas exosomal miR-103a, miR-145, and miR-885 were significantly downregulated in patients in the high D-dimer group compared to patients in the low D-Dimer group (p<0.0001).

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.