Corpus overview


Overview

MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    COVID-19 during pregnancy should we really worry from vertical transmission TRANS or rather from fetal hypoxia MESHD and placental insufficiency MESHD? A systematic review and meta -analysis

    Authors: Antoine AbdelMassih; Raghda Fouda; Rana Essam; Alhussein Negm; Dalia Khalil; Dalia Habib; George Afdal; Habiba-Allah Ismail; Hadeer Aly; Ibrahim Genedy; Layla El Qadi; Leena Makki; Maha Shulqamy; Maram Hanafy; Marian AbdelMassih; Marina Ibrahim; Mohamed Ebaid; Monica Ibrahim; Nadine El-Husseiny; Nirvana Ashraf; Noura Shebl; Rahma Menshawey; Rama Darwish; Rana ElShahawi; Rana Ramadan; Sadra Albala; Salwa Imran; Sama Ahmed; Samer Khaldi; Sara Abohashish; Stavro Paulo; Yasmin Omar; Mourad Alfy Tadros

    doi:10.21203/rs.3.rs-71847/v1 Date: 2020-09-03 Source: ResearchSquare

    Background:COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19 positive mothers.  The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive in COVID-19 positive mothers. Secondary outcomes included examining laboratory and placental abnormalities MESHD among fetus-mother pairs.Methods:Systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria.Results: Final screening revealed 66 studies, from which the primary data of 1787 mother-infant pairs was obtained. Only 2.8% of mother infant pairs were tested positive, and this finding is identical to percentages reported in former coronaviridae outbreaks. Whereas, 20% manifested with intrauterine hypoxia MESHD alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. Conclusions: These findings suggest that while vertical transmission TRANS is unlikely, there appears to be an underlying risk of placental insufficiency MESHD due to the prothrombotic tendency observed in COVID-19 infection MESHD. Guidelines for proper prophylactic anticoagulation in COVID positive mothers need to be established. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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