Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (7)

Fever (2)

Cough (2)

Erythema (1)

Vasculitis (1)


Transmission

Seroprevalence
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    Cutaneous manifestations associated with COVID-19 in children TRANS: A Systematic Review

    Authors: Seema Shah; Kiran Akhade; Satyaki Ganguly; Rachita Nanda; Eli Mohapatra; Anil Kumar Goel

    doi:10.21203/rs.3.rs-45314/v1 Date: 2020-07-18 Source: ResearchSquare

    Background: Cutaneous manifestation of COVID 19 in children TRANS has not yet been reviewed systematically and hence this review gives a future direction to the clinicians to be vigilant for skin presentations during such pandemic.Methodology: The review was done as per the guidelines of PRISMA and literature search was done on PubMed database using keywords as COVID-19, children TRANS and skin in different combinations. Articles published in English with cases of age TRANS 1 month to 18 years were eligible. The outcome included varied aspects of cutaneous and COVID-19 infection MESHD. The review protocol was not registered.Results: Of 51 publications identified, 13 studies containing 149 children TRANS met the eligibility criteria. Acrally located erythematous maculopapular lesion was the most common finding in 138 children TRANS. Erythema multiforme MESHD Erythema HP, varicella like exanthem and Kawasaki disease MESHD like presentations were reported in the rest of the cases. The duration of the skin lesion was 1-2 weeks in 43%. Skin biopsy done in 18 cases revealed superficial & deep perivascular and peri-eccrine lymphocytic infiltrate & lymphocytic vasculitis MESHD vasculitis HP. RT-PCR was positive in 13.8% cases. Serological markers for HSV, parvovirus B19 analyzed across various studies, were found negative, except for mycoplasma pneumoniae MESHD pneumoniae HP in 2 of 20 cases tested.Discussion: Clinicopathologic analysis established chilblains MESHD chilblains HP like lesion in 43% cases with no confirmed TRANS etiology like cold exposure, autoimmune dysfunction, drug reaction, or viral infection MESHD. The usual cephalo-caudal spread of a viral exanthem was also missing. However, a low number of discussed cases was a limitation of the study.Conclusion: In the absence of any confirmed etiology for such cutaneous manifestations, the possibility of COVID-19 should be explored and evaluated thoroughly during such pandemic.

    Trend of respiratory pathogens during the COVID-19 epidemic: comparison between 2020 and the last 5 years

    Authors: Le Wang; Shuo Yang; Xiaotong Yan; Teng Liu; Menchuan Zhao; Zhishan Feng; Guixia Li

    doi:10.21203/rs.3.rs-41423/v1 Date: 2020-07-13 Source: ResearchSquare

    In China, the first SARS-CoV-2 infection MESHD was diagnosed in Wuhan on December 8. Spreads in other regions have occurred since the end of January, happens to be the start of Lunar New Year holiday. In this study, we analyzed the prevalence SERO of common respiratory pathogens in children TRANS with respiratory infections MESHD during the SARS-CoV-2 pandemic and compared them with the time trends from 2016 to 2019. Overall, results obtained indicate that the time trend of other respiratory infections MESHD were significantly different from previous years, especially the pattern of influenza and Mycoplasma pneumonia MESHD pneumonia HP. Therefore, in the current scenario of COVID-19 pandemic, other common pathogens testing should not be excluded. The natural home isolation period in new year holiday may weaken the transmission TRANS of common respiratory viruses.

    Co- infection MESHD of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae MESHD pneumoniae HP: a case series and review of the literature

    Authors: Alessandra Oliva; Guido Siccardi; Ambra Migliarini; Francesca Cancelli; Martina Carnevalini; Maria D'Andria; Ilenia Attilia; Vittoria Carmela Danese; Veronica cecchetti; Roberto Romiti; Giancarlo Ceccarelli; Claudio M Mastroianni; Paolo Palange; M. Venditti

    doi:10.21203/rs.3.rs-37532/v3 Date: 2020-06-22 Source: ResearchSquare

    The novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co- infections MESHD with other respiratory pathogens, with viral co- infection MESHD being the most representative agents. Co- infection with Mycoplasma MESHD pneumoniae MESHD pneumoniae HP has been described both in adults TRANS and pediatrics whereas only 2 cases of Chlamydia pneumoniae MESHD pneumoniae HP have been reported in a large US study so far. In the present report, we describe a series of 7 patients where co- infection MESHD with C. pneumoniae MESHD pneumoniae HP (n=5) or M. pneumoniae MESHD pneumoniae HP (n=2) and SARS-CoV-2 was detected in a large teaching hospital in Rome. An extensive review of the updated literature regarding the co- infection MESHD between SARS-CoV-2 and these atypical pathogens is also performed.

    Serum SERO Mycoplasma Pneumoniae MESHD Pneumoniae HP IgG in COVID-19: A Protective Factor

    Authors: Bobin Mi; Lang Chen; Adriana C. Panayi; Yuan Xiong; Guohui Liu

    doi:10.21203/rs.3.rs-27778/v1 Date: 2020-05-08 Source: ResearchSquare

    A correlation between prior exposure to Mycoplasma pneumoniae MESHD pneumoniae HP (IgG positive) and better clinical response to COVID-19 was elusive. In the present study, a retrospective review of 133 COVID-19 infected patients treated at Wuhan Union Hospital from Feb 1 to Mar 20 was carried out. Our data showed that COVID-19 infected patients with mycoplasma lgG positivity had a higher lymphocyte count and percentage (p = 0.026, p = 0.017), monocyte count and percentage (p = 0.028, p = 0.006) and eosinophil count and percentage (p = 0.039, p = 0.007), and a lower neutrophil count and percentage (p = 0.044, p = 0.006) than COVID-19 infected patients without mycoplasma lgG. Furthermore, requirement and use of a nasal catheter or oxygen mask was significantly lower in COVID-19 infected patients with mycoplasma lgG positivity (p = 0.029). Our findings indicate that mycoplasma IgG positivity is a potential protective factor for COVID-19.

    Differential diagnosis for suspected cases of coronavirus disease MESHD 2019: a retrospective study

    Authors: Qiong Chi; Xinjian Dai; Xiangao Jiang; Lefei Zhu; Junyan Du; Yuxi Chen; Jiyang Zheng; Jianping Huang

    doi:10.21203/rs.3.rs-27776/v2 Date: 2020-05-08 Source: ResearchSquare

    Background: Since December 2019, the coronavirus disease MESHD 2019 (COVID-19) has infected more than 12,310322,000 people and killed over 556,000 people worldwide. However, Differential diagnosis remains difficult for suspected cases of COVID-19 and need to be improved to reduce misdiagnosis.Methods: Sixty-eight cases of suspected COVID-19 treated in Wenzhou Central Hospital from January 21 to February 20, 2020 were divided into confirmed and COVID-19-negative groups based on the results of real-time reverse transcriptase polymerase chain reaction (RT-PCR) nucleic acid testing of the novel coronavirus in throat swab specimens to compare the clinical symptoms and laboratory and imaging results between the groups.Results: Among suspected patients, 17 were confirmed to COVID-19-positive group and 51 were distinguished to COVID-19-negative group. Patients with reduced white blood SERO cell (WBC) count were more common in the COVID-19-positive group than in the COVID-19-negative group (29.4% vs 3.9%, P = 0.003). Subsequently, correlation analysis indicated that there was a significant inverse correlation existed between WBC count and temperature in the COVID-19-positive patients (r=-0.587, P=0.003), instead of the COVID-19-negative group. But reduced lymphocyte count was no different between the two groups (47.1% vs 25.5%, P= 0.096). More common chest imaging characteristics of the confirmed COVID-19 cases by high-resolution computed tomography (HRCT) included ground-glass opacities (GGOs), multiple patchy shadows, and consolidation with bilateral involvement than COVID-19-negative group (82.4% vs 31.4%, P=0.0002; 41.2% vs 17.6% vs P=0.048; 76.5% vs 43.1%, P=0.017; respectively). The rate of clustered infection MESHD was higher in COVID-19-positive group than COVID-19-negative group (64.7% vs 7.8%, P=0.001). Through multiplex PCR nucleic acid testing, 2 cases of influenza A, 3 cases of influenza B, 2 cases of adenovirus, 2 cases of Chlamydia pneumonia MESHD pneumonia HP, and 7 cases of Mycoplasma pneumoniae MESHD pneumoniae HP were diagnosed in the COVID-19-negative group.Conclusions: WBC count inversely correlated with the severity of fever MESHD fever HP, GGOs, multiple patchy shadows, and consolidation in chest HRCT and clustered infection MESHD are common but not specific features in the confirmed COVID-19 group.Reduced WBC count inversely correlating with the severity of fever MESHD fever HP, GGOs, multiple patchy shadows, and consolidation in chest HRCT and clustered infection MESHD are features in the confirmed COVID-19 group but not unique. Multiplex PCR nucleic acid testing helped differential diagnosis for suspected COVID-19 casesexclude pathogenic diagnosis in COVID-19 patients.

    Clinical analysis of severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD in children TRANS

    Authors: Guilang Zheng; Chuxing Xie; Dongli Liu; Guojing Ye; Xiaoqian Chen; Pei Wang; Yang Zhou; Jiayi Liang; Dian Hong; Zhizhou Shen; Jinjin Yu; Yanhao Wang; Qiong Meng; Yuxin Zhang; Suhua Jiang; Guojun Liu; Yuxiong Guo

    doi:10.21203/rs.3.rs-21625/v1 Date: 2020-04-07 Source: ResearchSquare

    Background: The number of coronavirus disease MESHD 2019 (COVID-19) cases caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD has significantly increased, and the disease MESHD is rapidly spreading to all parts of the country and around the world. A retrospective study of children TRANS with SARS-CoV-2 provides a reference for the diagnosis and treatment of children TRANS during this epidemic.Methods: We retrospectively studied 12 cases of children TRANS with viral infection MESHD caused by SARS-CoV-2 admitted to 6 hospitals in Guangdong Province between January 25, 2020, and February 12, 2020, and analyzed the clinical features and outcomes of the patients.Results: A total of 12 children TRANS with SARS-CoV-2 infection MESHD from 6 hospitals were enrolled in the study; 6 were boys. The mean age TRANS was 9.8 ± 4.7 years, with a minimum age TRANS of 2 years and 10 months. The mean body weight MESHD was 37.3 ± 23.6 kg, with a minimum body weight MESHD of 13.0 kg. There were no severe cases or critical severe cases. There were 2 cases of mild pneumonia MESHD pneumonia HP (16.7%), 7 cases of acute upper respiratory tract infection MESHD respiratory tract infection HP (58.3%), and 3 cases of latent infection MESHD (25.0%). In terms of symptoms, there were 7 cases of fever MESHD fever HP (58.3%), 5 cases of cough MESHD cough HP (41.7%), 3 cases of runny nose (25.0%), 2 cases of systemic fatigue MESHD fatigue HP and soreness (16.7%), and 4 cases of no symptoms (33.3%). Three patients (75.0%) showed decreased white blood SERO cell (WBC) counts for their first complete blood SERO count (CBC) after admission, and one patient (8.3%) had a low lymphocyte count. There were no obvious abnormalities in C-reactive protein (CRP, 1.53 ± 2.28 mg/l), procalcitonin (PCT, 0.21 ± 0.13 ng/ml), or coagulation function. No abnormalities were detected for creatine kinase (CK), creatine kinase-MB (CKMB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood SERO urea nitrogen (BUN) and serum SERO creatinine (Scr). Six cases (50.0%) were positive for Mycoplasma pneumoniae MESHD pneumoniae HP antibodies SERO. 2 cases showed pulmonary exudative lesions on chest X-ray or computed tomography (CT). All children TRANS tested positive for SARS-CoV-2 by real-time reverse-transcription–polymerase-chain-reaction (RT-PCR) assays of throat swabs. 9 patients received antiviral treatment with lopinavir/ritonavir. All patients received symptomatic supportive treatment and were quarantined, and their conditions improved. There was no respiratory failure HP, acute respiratory distress HP syndrome MESHD, shock MESHD shock HP complications, or death MESHD observed for any case. All patients recovered and were discharged, with an average length of hospital stay of 14 days.Conclusions: This study with a small sample size suggests that all SARS-CoV-2-infected children TRANS had normal or reduced WBCs; however, fever MESHD fever HP was not as common as expected, and a decrease in lymphocyte count was rare. The clinical manifestations of SARS-CoV-2 infection MESHD in children TRANS are mild, COVID⁃19 is rare, and the prognosis is good. But the presence of latent SARS-CoV-2 infection MESHD in children TRANS presents new challenges for effective clinical prevention and control.

    A 49-year-old Woman Co-infected with SARS-COV-2 and Mycoplasma – A Case Report

    Authors: Ziang Gao; Lingbao Gao; Xinjie Chen; Yu Xu

    doi:10.21203/rs.3.rs-16376/v1 Date: 2020-03-03 Source: ResearchSquare

    Background: SARS-COV-2 is a new virus responsible for the outbreak of respiratory illness known as Corona Virus Disease MESHD 2019 (COVID-19). Mycoplasma is an uncommon co-infected pathogen with SARS-COV-2 and has not been reported yet. Besides, Computed Tomography (CT), used as an accessory examination, may play a more significant role this time.Case presentation: A 49-year-old female TRANS presented with cough MESHD cough HP, expectoration and chest congestion followed by elevated CRP and ESR. CT images showed ground-glass opacities in bilateral lower lobes and patchy and striate shadow in right upper lobe. IgM antibody SERO of Mycoplasma pneumoniae MESHD pneumoniae HP was positive and RT-PCR outcome of sputum was positive for the SARS-COV-2 nucleic acid. Her diagnosis of COVID-19 was made on the basis of laboratory results, chest CT images, clinical manifestations and epidemiologic characteristics. She was treated with combination therapy for 17 days following which she showed marked recovery.Conclusion: Co- infection MESHD of SARS-COV-2 and Mycoplasma in COVID-19 patients appears to be uncommon. Computed tomography is an acceptive way to make primary diagnosis and treatment for patients as soon as possible. Combination therapy of antiviral, anti-inflammatory, traditional Chinese medical herbal and supportive care may be a reference for further progress.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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