Corpus overview


MeSH Disease

Human Phenotype


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    Spontaneous Pneumothorax HP Pneumothorax MESHD as Unusual Presenting Symptom of Covid-19 Pneumonia MESHD Pneumonia HP: Surgical Management and Pathological Findings

    Authors: Roberto Bellini; MARIA CHIARA SALANDINI; Serena Cuttin; Stefania Mauro; Paolo Scarpazza; Christian Cotsoglou

    doi:10.21203/ Date: 2020-07-28 Source: ResearchSquare

    Spontaneous pneumothorax HP pneumothorax MESHD has been reported as a possibile complication of novel coronavirus associated pneumonia MESHD pneumonia HP (COVID-19). We report two cases of COVID-19 patients who developed spontaeous and recurrent pneumothorax MESHD pneumothorax HP as a presenting symptom, treated with surgical procedure. Intraoperative findings of COVID-19 pneumonia MESHD pneumonia HP were parenchymal atelectasis HP and vascular congestion. Lung tissue was very frail and prone to bleeding. Histological examination showed interstitial infiltration of lymphocytes and plasma SERO cells, as seen in non specific interstitial pneumonia MESHD pneumonia HP, together with myo-intimal thicknening of vessels with blood SERO extravasation and microthrombi. Lung surgery for pneumothorax MESHD pneumothorax HP in COVID-19 patients can be safely and effectively performed when necessary.

    Expectant Management of Pneumothorax MESHD Pneumothorax HP in Intubated COVID 19 Positive Patients: A Case Series

    Authors: Colby Elder; Sheina Bawa; Douglas Anderson; Stephen Atkinson; Joshua Etzel; Troy Moritz

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: There is an increasing amount of literature describing the pathogenesis of coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP and its associated complications. Historically, a small pneumothorax MESHD pneumothorax HP has been shown to be successfully treated without chest tube insertion, but this management has yet to be proven in COVID-19 pneumonia MESHD pneumonia HP patients. In addition, pneumothorax MESHD pneumothorax HP in an intubated patient with high positive end-expiratory pressure (PEEP) provides additional uncertainty with pursuing non-operative management. Case Presentation:  In this series we report four cases of patients with respiratory distress HP who tested positive for COVID-19 via nasopharyngeal swab and developed ventilator-induced pneumothoraces MESHD pneumothoraces HP which were successfully managed with observation alone.Conclusions:  Management of patients with COVID-19 pneumonia MESHD pneumonia HP on positive pressure ventilation who develop small stable pneumothoraces MESHD pneumothoraces HP can be safely observed without chest tube insertion.

    Lung Ultrasound Findings in Patients Hospitalized with Covid-19

    Authors: Andre D Kumar; Sukyung Chung; Youyou Duanmu; Sally Graglia; Farhan Lalani; Kavita Gandhi; Viveta Lobo; Trevor Jensen; Yingjie Weng; Jeffrey Nahn; John Kugler

    doi:10.1101/2020.06.25.20140392 Date: 2020-06-28 Source: medRxiv

    Introduction: Point-of-care ultrasound (POCUS) has the potential to transform healthcare delivery in the era of COVID-19 with its diagnostic and therapeutic expediency. It can be performed by clinicians already at the bedside, which permits an immediate and augmented assessment of a patient. Although lung ultrasound can be used to accurately diagnose a variety of disease MESHD states such as pneumothorax MESHD pneumothorax HP, pleural effusions MESHD pleural effusions HP, pneumonia MESHD pneumonia HP and interstitial lung disease2, there are limited reports on the sonographic manifestations of COVID-19. There is an urgent need to identify alternative diagnostic modalities that can be immediately employed at the bedside of COVID-19 patients. Methods: This study was conducted at two medical centers in the United States from 3/21/2020-6/01/2020. Any adult TRANS who was hospitalized with COVID-19 (based on symptomatology and a confirmatory RT-PCR for SARS-CoV-2) and received a pulmonary POCUS examination was included. Providers were instructed to use a 12-zone scanning protocol for pulmonary views and save 6 second clips of each lung zone. This study utilized several POCUS devices, including Butterfly IQ, Vave, Lumify, and Sonosite. The collected images were interpreted by the study researchers based on a consensus document developed by the study authors and previously accepted definitions of lung POCUS findings. Results: A total of 22 eligible patients who received 36 lung scans were included in our study. Eleven (50%) patients experienced clinical deterioration MESHD (defined as either ICU admission, invasive mechanical ventilation, or death MESHD within 28 days from the initial symptom onset TRANS). Among the 36 lung scans collected, only 3 (8%) were classified as normal. The remaining scans had the following abnormalities: presence of B-lines (n=32, 89%), consolidations (n=20, 56%), pleural thickening HP (n=17, 47%), and pleural effusion MESHD pleural effusion HP (n=4, 11%). Out of 20 scans with consolidations, 14 (70%) were subpleural and 5 (25%) were translobar. A-lines were present in 26 (72%) of patients, although they were only observed in the majority of the collected lung zones in 5 (14%) of patients. Ultrasound findings were stratified by time from symptom onset TRANS to the scan based on the following time periods: early (0-6 days), middle (7-13 days), and late (14-28 days). B-lines appeared early after symptom onset TRANS and persisted well into the late disease MESHD course. In contrast, pleural thickening HP increased in frequency over time (early: 25%, middle: 47%, late: 67%). Subpleural consolidations also appeared in higher frequency later in the disease MESHD course (early: 13%, middle 42%, late: 56%). Discussion: certain lung ultrasound findings may be common in Covid-19, while others may appear later in the disease MESHD course or only occur in patients who experience clinical deterioration MESHD. Future efforts should investigate the predictive utility of consolidations, pleural thickening HP and B-lines for clinical deterioration MESHD and compare them to traditional radiological studies such as X-rays or CTs.

    Fast Deep Learning Computer-Aided Diagnosis against the Novel COVID-19 pandemic from Digital Chest X-ray Images

    Authors: Mugahed A. Al-antari; Cam-Hao Hua; Sungyoung Lee

    doi:10.21203/ Date: 2020-06-18 Source: ResearchSquare

    Background and Objective: The novel coronavirus 2019 (COVID-19) is a harmful lung disease MESHD that rapidly attacks people worldwide. At the end of 2019, COVID-19 was discovered as mysterious lung disease MESHD in Wuhan, Hubei province of China. World health organization (WHO) declared the coronavirus outbreak a pandemic in the second week of March 2020. Simultaneous deep learning detection and classification of COVID-19 from the entire digital X-ray images is the key to efficiently assist patients and physicians for a fast and accurate diagnosis.Methods: In this paper, a deep learning computer-aided diagnosis (CAD) based on the YOLO predictor is proposed to simultaneously detect and diagnose COVID-19 among the other eight lung diseases MESHD: Atelectasis HP, Infiltration, Pneumothorax MESHD Pneumothorax HP, Mass, Effusion, Pneumonia MESHD Pneumonia HP, Cardiomegaly MESHD Cardiomegaly HP, and Nodule. The proposed CAD system is assessed via five-fold tests for multi-class prediction problem using two different databases of chest X-ray images: COVID-19 and ChestX-ray8. The proposed CAD system is trained using an annotated training set of 50,490 chest X-ray images.Results: The suspicious regions of COVID-19 from the entire X-ray images are simultaneously detected and classified end-to-end via the proposed CAD predictor achieving overall detection and classification accuracies of 96.31% and 97.40%, respectively. The most testing images of COVID-19 and other lunge diseases MESHD are correctly predicted achieving intersection over union (IoU) with their GTs greater than 90%. Applying deep learning regularizers of data balancing and augmentation improve the diagnostic performance SERO by 6.64% and 12.17% in terms of overall accuracy and F1-score, respectively. Meanwhile, the proposed CAD system presents its feasibility to diagnose the individual chest X-ray image within 0.009 second. Thus, the presented CAD system could predict 108 frames/second (FPS) at the real-time of prediction.Conclusion: The proposed deep learning CAD system shows its capability and reliability to achieve promising COVID-19 diagnostic performance SERO among all other lung diseases MESHD. The proposed deep learning model seems reliable to assist health care systems, patients, and physicians in their practical validations.

    A Case Report of Spontaneous Pneumothorax HP Pneumothorax MESHD in the 2019 Novel Coronavirus–Infected Pneumonia MESHD Pneumonia HP

    Authors: Yunhu Pan; Shuo Wei; Guang Chen; Yuancheng Hong

    doi:10.21203/ Date: 2020-06-08 Source: ResearchSquare

    Background: COVID-19,which pathogen virus officially named SARS-CoV-2, started in China Wuhan city and so far rapidly spread to a global outbreak. Since the lung is the main lesion organ for virus invasion, Chest CT is strongly recommended in COVID-19 on either initial diagnosis and follow-up.Multiple patchy shadows and ground glass opacity of bilateral lung are typical features of CT scan,and spontaneous pneumothorax HP pneumothorax MESHD appeared in the early onset of COVID-19 is rare. Case Presentation: We reported one case of spontaneous pneumothorax HP pneumothorax MESHD in the early onset of COVID-19, chest CT showed only a small amount of pneumothorax MESHD pneumothorax HP were seen in the right lobe.After receiving 4 days of treatment, re-examination chest CT shows right pneumothorax MESHD pneumothorax HP disappeared, but the patient was clinically worse, and progressive multiple diffuse consolidation. Although treatment with extracorporeal membrane oxygenator,the patient died 15 days after admission. Conclusion: Spontaneous pneumothorax HP pneumothorax MESHD in the early stages of COVID-19 is rare,which imaging features differ from other lung diseases MESHD complicated with pneumothorax MESHD pneumothorax HP,such as COPD.More than we usually know,the improvement of pneumothorax MESHD pneumothorax HP and the outcome of COVID-19 may be inconsistent.

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MeSH Disease
Human Phenotype

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