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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    High in-hospital mortality due to COVID-19 in a community hospital in Spain: a prospective observational study

    Authors: Joan Carles Trullàs; Eva Ruiz; Clara Weisweiler; Gemma Badosa; Alba Serra; Hugo Briceño; Sílvia Soler; Josep Bisbe

    doi:10.21203/rs.3.rs-39421/v1 Date: 2020-07-01 Source: ResearchSquare

    Background To describe the clinical characteristics and outcome of patients with COVID-19 in a community hospital in SpainMethods Prospective, single-centre case series of the first 100 consecutive hospitalized patients with COVID-19 at a community hospital in Spain, from March 16 to April 20, 2020. Demographics, comorbidities, clinical presentation, radiologic and laboratory findings, treatment and clinical outcome were collected.Results Of the 100 patients included in the study, the median age TRANS (IQR; range) was 75 years (20; 28–96) and 52% were men. The most common comorbidities were hypertension MESHD hypertension HP (63%), diabetes (22%) and cardiovascular diseases MESHD (28%). The most common symptoms were fever MESHD fever HP (80%), cough MESHD cough HP (69%), fatigue MESHD fatigue HP (59%) and dyspnea MESHD dyspnea HP (52%) and 64% had respiratory insufficiency MESHD respiratory insufficiency HP. Bilateral interstitial infiltrates (65/100, 65%) and bilateral vertical “B-kerley” lines (38/46, 82.6%) were the most common imaging manifestations in chest radiographs and lung ultrasound, respectively. All patients received supplementary oxygen, 69 (69%) received medical treatment (the most common regimen being hydroxychloroquine plus azithromycin in 66 patients) and 12% were treated with glucocorticoids. During hospitalization, 26 patients (26%) died, 10 (10%) were transferred to ICU and 64 (64%) were discharged at home. Mortality or ICU admission was more frequent in advanced age TRANS and with comorbidities.Conclusions This case series provides clinical characteristics and outcome of consecutively hospitalized patients with COVID-19 admitted to a community hospital in Spain. The majority were old patients, with comorbidities and in-hospital mortality was high (26%).

    COVID-19 Pandemic in Bergamo outbreak: a call to war. Implementation of a “COVID-Hospital” model in ASST Bergamo-Est Trust as a disaster-response strategy.

    Authors: Edoardo Iaculli; Michele Marini; Isabella Pezzoli; Luisella Spinelli; Lorenzo Vescovi; Silvia Frassini; Francesca Rubertà; Nadiane Paderno; Rosalba Della Nave; Elisa Da Re; Hamade Abdel Meneme; Delia Beatrice Bonzi; Alberto Mario Guglielmo Leone Tedeschi; Alessandro Iaculli; Giuseppe Nastasi; Pierpaolo Mariani; Antonio Piazzini Albani

    doi:10.21203/rs.3.rs-36513/v1 Date: 2020-06-19 Source: ResearchSquare

    Background: COVID-19 is a strikingly emerging disease MESHD caused by a new coronavirus (SARS-CoV-2) that has rapidly spread across all continents and affecting virtually every country. From a clinical, epidemiological, political and financial perspective, COVID-19 pandemic is now recognized as one of the worst disasters in modern era. In the North of Italy, Bergamo has been the European equal to Chinese City of Wuhan in terms of epidemiological impact of COVID-19. The first case of SARS-Cov-2 infection MESHD in Bergamo has been reported in Alzano District General Hospital (DGH), part of ASST Bergamo-Est Multi Hospitals Network. ASST Bergamo-Est comprises four Hospitals serving more than 50% of Bergamo Province and with a patient catchment of 387000 inhabitants. Methods: We retrospectively analyze the challenges and actual impact of the SARS-CoV-2 pandemic on the hospital capacity and performance SERO. Accordingly, we report the specific operational procedures and clinical governance implementation related to the transformation of our Institutions into “COVID-hospitals”. Results: From 1st of March to 20th of April, 4919 consecutive patients were assessed in ASST Bergamo-Est Hospitals as “COVID-Hospital” referral centre, of these 1412 patients were admitted with diagnosis of moderate to severe COVID-19 respiratory insufficiency MESHD respiratory insufficiency HP. Most of patients were high-risk individuals with a median age TRANS of 69 years. In-hospital mortality rate was 33.1%. Specific performance SERO improvements under the “COVID-19 Hospital model” capacity-expansion strategy were analysed. Conclusions: This paper informs on the experience of ASST Bergamo-Est Trust and the disaster-response strategy during the COVID-19 pandemic. The ASST Bergamo-Est data reported corroborates the recent call for action to Governments for promoting MCI improved management with focus on COVID-19 pandemic and its possible recurrence MESHD

    Lung Mechanics in Type L CoVID-19 Pneumonia MESHD Pneumonia HP: A Pseudo-Normal ARDS.

    Authors: Lorenzo Viola; Emanuele Russo; Marco Benni; Emiliano Gamberini; Alessandro Circelli; Luca Bissoni; Domenico Pietro Santonastaso; Giovanni Scognamiglio; Giuliano Bolondi; Luca Mezzatesta; Vanni Agnoletti

    doi:10.21203/rs.3.rs-37028/v1 Date: 2020-06-19 Source: ResearchSquare

    Since its outbreak, in January, 2020, it has been clear that CoVID-19 pneumonia MESHD pneumonia HP is atypical. Despite a full concordance to Berlin criteria for Acute Respiratory Distress HP Syndrome MESHD (ARDS), respiratory system mechanics is preserved [1]. Mechanical ventilation and muscular paralysis MESHD paralysis HP are recommended in worsening respiratory insufficiency MESHD respiratory insufficiency HP [2]; in a substantial number of cases, prone positioning significantly improves oxygenation.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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