Corpus overview


MeSH Disease

Human Phenotype


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    Aneurysmal Subarachnoid Haemorrhage After COVID-19 Infection MESHD

    Authors: Sajjad Muhammad; Soheil Naderi; Mostafa Ahmadi; Askar Ghorbani; Daniel Hänggi

    doi:10.21203/ Date: 2020-07-24 Source: ResearchSquare

    BackgroundSARS-CoV-2 virus infection MESHD leads to a severe and dysbalanced inflammatory response with hypercytokinemia and immunodepression. Systemic inflammation MESHD due to viral infections MESHD can potentially cause vascular damage including disruption of blood SERO-brain barrier (BBB) and alterations in coagulation system that may also lead to cardiovascular and neurovascular events. Here, we report the first case of COVID-19 infection MESHD leading to aneurysmal subarachnoid haemorrhage (aSAH). Case DescriptionA 61-year-old woman presented with dyspnea MESHD dyspnea HP, cough MESHD cough HP and fever MESHD fever HP. She was over weight with Body MESHD mass-index of 34 and history of hypertension MESHD hypertension HP. No history of subarachnoid hemorrhage MESHD subarachnoid hemorrhage HP in the family. She was admitted in ICU due to low oxygen saturation (89%). A chest CT showed typical picture of COVID-19 pneumonia MESHD pneumonia HP. Oropharyngeal swab with a PCR-based testing was COVID-19 positive. She was prescribed with favipiravir and hydroxychloroquine in Addition to oxygen support. On second day she experienced sudden headache MESHD headache HP and losst conciousness. A computer tomography (CT) with CT-angiography revealed subarachnoid haemorrhage in basal cisterns from a ruptured MESHD anterior communicating artery aneurysm MESHD. The aneurysm MESHD was clipped microsurgically through a standard pterional approach and the patient was admitted again to intensive care unit for further intensive medical treatment. Post-operative the patient showed slight motor dysphasia HP. No other neurological deficits.ConclusionAneurysmal subarachnoid haemorrhage secondary to COVID-19 infection MESHD might be triggered by systemic inflammation MESHD. COVID-19 infection MESHD could be one of the risk factors leading to instability and rupture MESHD of intracranial aneurysm MESHD.

    TAE Combined with Microwave Ablation in the Treatment of Rare Giant Hepatic Hemangioma HP Hemangioma MESHD:Case Report and Literature Review

    Authors: Yi-fu Feng; Xin-yi Chen; Jing-gang Mo; Hai-ling Wu; Jian-yu Zhou; Chong Jin; Hao Jiang; Wang Kun-Peng

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    Background: hepatic hemangioma HP hemangioma MESHD is the most common benign tumor of the liver. However, patients with large hemangiomas MESHD hemangiomas HP that cause compression symptoms or that are at risk of rupture MESHD may need further intervention. It is necessary to explore additional minimally invasive and personalized treatment options.Case presentation: A 47-year-old female TRANS was diagnosed with right hepatic hemangioma HP hemangioma MESHD for more than 10 years. Abdominal contrast-enhanced CT and CEUS revealed that there was a large hemangioma MESHD hemangioma HP in the right liver, with a size of approximately 95x97x117 mm. Due to the patient's refusal of surgical treatment, hepatic artery embolization was performed in the first stage, then after 25 days of liver protection treatment, the liver function indexes decreased to normal levels. Then, B-ultrasound-guided microwave ablation of the giant hepatic hemangioma HP hemangioma MESHD was performed. Ten days after the surgery, hepatobiliary ultrasonography showed that the hemangioma MESHD hemangioma HP of the right liver was smaller than the previous size (the volume was reduced by approximately 30%). Then the patient was discharged from the hospital, and CT suggested that the hepatic hemangioma HP hemangioma MESHD is significantly smaller two months after discharge. Because of COVID-19, the patient's CT examination was delayed.Conclusions: TAE combined with microwave ablation is a safe and effective minimally invasive treatment for hepatic hemangioma HP hemangioma MESHD.

    The presentation of spontaneous splenic rupture MESHD splenic rupture HP in a COVID-19 patient: a case report

    Authors: Mohammadreza Mobayen; Saeed Yousefi; Mohammadsadegh Mousavi; Amin Shafighi Anbaran

    doi:10.21203/ Date: 2020-07-09 Source: ResearchSquare

    Introduction: Splenic rupture MESHD Splenic rupture HP is an emergency MESHD condition and the vast numbers of cases are secondary TRANS to trauma. Several underlying pathologies have also been associated with splenic rupture MESHD splenic rupture HP, such as hematological diseases MESHD, malignancies, and infectious and inflammatory diseases MESHD.Presentation of case: The patient was a 52-year-old man who referred to the Poursina Hospital in Rasht while complaining of abdominal pain MESHD abdominal pain HP from the day before hospitalization. The patient reported a history of lethargy MESHD lethargy HP, fever MESHD fever HP, and nausea MESHD nausea HP. In the examinations performed, there was a brief tenderness in the patient's epigastrium. The patient was monitored and about 12 hours after hospitalization, ill appearance, respiratory ( respiratory distress HP) symptoms, and high fever MESHD fever HP were reported for the patient. According to the examination, the patient was immediately transferred to the operating room and underwent laparotomy. During the operation, contrary to our expectations, a lot of blood SERO (about 1000 cc) was observed in the patient's abdomen. After blood SERO suctioning, the left upper quadrant (LUQ) was bleeding and the rupture MESHD of the spleen could also be observed. Therefore, a splenectomy was performed .In the examinations performed for the patient, the patient's rtPCR test confirmed COVID-19.Conclusion: The evaluation of the spontaneous splenic rupture MESHD splenic rupture HP (SSR) in our case shows that this type of risk should also be considered in patients with COVID-19 who referred to medical centers with abdominal pain MESHD abdominal pain HP, and if more cases are reported, the correctness of this process can be commented on.

    SARS-CoV-2 envelope protein causes acute respiratory distress HP syndrome MESHD (ARDS)-like pathological damage and constitutes an antiviral target

    Authors: Zhaobing Gao; Bingqing Xia; Xurui Shen; Yang He; Xiaoyan Pan; Yi Wang; Feipu Yang; Sui Fang; Yan Wu; Xiaoli Zuo; Zhuqing Xie; Xiangrui Jiang; Hao Chi; Qian Meng; Hu Zhou; Yubo Zhou; Xi Cheng; Tong Cheng; Xiaoming Xin; Hualiang Jiang; Gengfu Xiao; Qiang Zhao; Lei-Ke Zhang; Jingshan Shen; Jia Li

    doi:10.1101/2020.06.27.174953 Date: 2020-06-29 Source: bioRxiv

    Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death MESHD. However, the origin of the virus excessively damaging abilities remains unknown. Here we show that the SARS-CoV-2 envelope (2-E) protein alone is sufficient to cause acute respiratory distress HP syndrome MESHD (ARDS)-like damage in vitro and in vivo. Overexpression of 2-E protein induced rapid pyroptosis-like cell death MESHD in various susceptible cells and robust secretion of cytokines and chemokines in macrophages. Intravenous administration of purified 2-E protein into mice caused ARDS-like pathological damage in lung and spleen. Overexpressed 2-E protein formed cation channels in host cell membranes, eventually leading to membrane rupture MESHD. Newly identified channel inhibitors exhibited potent anti-SARS-CoV-2 activity and excellent protective effects against the 2-E-induced damage both in vitro and in vivo. Importantly, their channel inhibition, cell protection and antiviral activities were positively correlated with each other, supporting 2-E is a promising drug target against SARS-CoV-2.

    Exposure risk of patients with chronic infectious wounds during the COVID-19 outbreak and its countermeasures

    Authors: Haiying Zhou; Qianjun Jin; hui lu

    doi:10.21203/ Date: 2020-06-18 Source: ResearchSquare

    BACKGROUND A large number of cases of pneumonia MESHD pneumonia HP caused by novel β-coronavirus emerged in Hubei Province, China, at the end of 2019 and demonstrated great potential for transmission TRANS. At present, known independent risk factors include age TRANS, diabetes and other chronic diseases MESHD, which may be similar to the patients with chronic wound, thus we try to explore the clinical characteristics, prognostic factors and management recommendation of patients with chronic infective wounds during the COVID-19 epidemic period. METHODS In this single-center, retrospective observational study, we included all cases with chronic infective wounds that came to our hospital between the full outbreak of the COVID-19 in China (January 23, 2020) and the latest date prior to posting (20 April 2020). Demographic data, comorbidities, laboratory and imaging findings, consultation history and clinical outcomes (lesion cured, uncontrolled, amputated, etc. as of May 10, 2020) were collected for all individuals. Patients were subdivided into gangrene MESHD gangrene HP, traumatic infection MESHD and other types of soft tissue infection MESHD wound (including bedsores, gout MESHD gout HP ruptures MESHD, stab wounds MESHD and so on) according to the causes of wound and their disease MESHD-related information were compared group by group. RESULTS Among the total 81 patients with chronic infective wounds, 60% was male TRANS, with a mean age TRANS of 60.8 years (SD 18.6), including 38 (47%) patients with traumatic infection MESHD, 29 (36%) gangrene MESHD gangrene HP cases, and 14 (17%) other soft tissue infection MESHD wounds. Common comorbidities are hypertension MESHD hypertension HP (32%), diabetes (32%), cardiovascular disease MESHD (24%), and kidney injury (12%), and the patients with gangrenes MESHD gangrenes HP have the most comorbidities. As of May 10, 2020, there were 78 patients discharged and their average stay time is 15.8 days(SD 14.2), while people still at the hospital is 39.7days(SD 8.7)much longer than the discharged and also has more comorbidities. But there is no significant difference in the hospitalization time of three types of wounds. And fortunately, none of all the patients were infected by coronavirus. CONCLUSION The majority of patients with chronic wounds are severely ill with high risk of infection TRANS risk of infection TRANS infection MESHD and poor prognosis, therefore management of patients with chronic wounds should be improved.

    Clinical Features of Pregnant Women and Neonates with COVID-19 in Wuhan: a paired comparison study

    Authors: Qin Xie; Quan Gan; Jing Hu; Dong Zhou; Shuhan Cai; Lianjiu Su; Yunxiang Li; Yiming Li; Zhiyong Peng

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Our study aimed to find symptoms unique in pregnancy and to help the early diagnosis in pregnant women and to evaluate the impact of COVID-19 in postpartum women and their newborns.Methods Clinical data were reviewed and collected for 11 pregnant women with laboratory-confirmed COVID-19 who were consecutively admitted to Zhongnan Hospital of Wuhan University and Women and Children’s Hospital of Hubei Province, from Jan 26 to Feb 26, 2020.Results All the confirmed women didn’t have any exposure history and their early symptoms were mildly elevated temperate and fatigue MESHD fatigue HP. The chest CT scans of confirmed women can be atypical manifestations, such as bilateral pleural effusions MESHD pleural effusions HP and slightly increased densities. Eight of eleven confirmed women did not feel anything unusual until abnormalities were found on chest CT scans on admission screening test. All three groups had elevated white blood SERO cell count, neutrophil count and lactate dehydrogenase, and reduced total protein.The infection MESHD did not increase the risk for premature delivery, premature rupture of membrane HP rupture MESHD of membrane, or comorbidities in pregnancy.Conclusions Pregnant women were often asymptomatic TRANS and accidentally detected abnormalities on chest CT scan on admission which emphasize the importance of CT scan in prevalent areas of the COVID-19. Even after the laboratory confirmation, the manifestation of the CT scan could be atypical, which alerted the necessity of protection for healthcare workers. The COVID-19 did not increase the risk of complications in pregnant women and their neonates.Trial registration: This case series was approved by the institutional ethics board of Zhongnan Hospital of Wuhan University (No. 2020020) and Women and Children’s Hospital of Hubei Province(NO. LW035).

    Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors to Drive Pathogenesis of SARS-CoV-2

    Authors: Nancy Ashray; Anshul Bhide; Priyanka Chakarborty; Stacy Colaco; Anuradha Mishra; Karisma Chhabria; Mohit Kumar Jolly; Deepak Modi

    id:10.20944/preprints202005.0195.v1 Date: 2020-05-11 Source:

    Infection MESHD Infection by the Severe HP by the Severe Acute Respiratory Syndrome MESHD-Coronavirus-2 (SARS-CoV-2) results in the novel coronavirus disease MESHD COVID-19, which has posed a serious threat globally. Infection MESHD of SARS-CoV-2 during pregnancy is associated with complications like preterm labor and premature rupture of membranes HP rupture MESHD of membranes; a proportion of neonates born to the infected mothers are also positive for the virus. During pregnancy, the placental barrier protects the fetus from pathogens and ensures healthy development. However, whether or not SARS-CoV-2 can infect the placenta is unknown. Herein, utilizing single-cell RNA-seq data, we report that the SARS-CoV-2 binding receptor ACE2 and the S protein priming protease TMPRSS2 are co-expressed by a subset of syncytiotrophoblasts (STB) in the first trimester and extra villous trophoblasts (EVT) in the second trimester human placenta. The ACE2- and TMPRSS2-positive (ACE2+TMPRSS2+) placental subsets express mRNA for proteins involved in viral budding and replication. These cells also express mRNA for proteins that interact with SARS-CoV-2 structural and non-structural proteins in the host cells. We also discovered unique signatures of genes in ACE2+TMPRSS2+ STBs and EVTs. The ACE2+TMPRSS2+ STBs are highly differentiated cells and express genes involved mitochondrial metabolism and glucose transport. The second trimester ACE2+TMPRSS2+ EVTs are enriched for markers of endovascular trophoblasts. Further, both these subtypes abundantly expressed genes in Toll like receptor pathway, the second trimester EVTs (but not first trimester STBs) are also enriched for component of the JAK-STAT pathway that drive inflammation MESHD. To conclude, herein we uncovered the cellular targets for SARS-CoV-2 entry and show that these cells can potentially drive viremia MESHD viremia HP in the developing human placenta. Our results provide a basic framework towards understanding the paraphernalia involved in SARS-CoV-2 infections MESHD in pregnancy.

    Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission TRANS of SARS-CoV-2 in women with COVID-19: A systematic review

    Authors: Rahul Gajbhiye; Deepak Modi; Smita Mahale

    doi:10.1101/2020.04.11.20062356 Date: 2020-04-15 Source: medRxiv

    Abstract Objective: The aim of this systematic review was to examine published and preprint reports for maternal and fetal outcomes in pregnant women with COVID-19 and also assess the incidence of maternal-fetal transmission TRANS of SARS CO-V-2 infection MESHD. Design : Systematic review Data sources:We searched PUMBED. Medline, Embase, MedRxiv and bioRxiv databases upto 31st March 2020 utilizing combinations of word variants for " coronavirus " or " COVID-19 " or " severe acute respiratory syndrome MESHD " or " SARS-COV-2 " and " pregnancy " . We also included data from preprint articles. Study selection : Original case reports and case series on pregnant women with a confirmed diagnosis of SARS-CoV-2 infection MESHD. Data extraction : We included 23 studies [China (20), USA (01), Republic of Korea (01) and Honduras, Central America (01) reporting the information on 172 pregnant women and 162 neonates. The primary outcome measures were maternal health characteristics and adverse pregnancy outcomes, neonatal outcomes and SARS-CoV-2 infection MESHD in neonates was extracted. Treatments given to pregnant women with COVID-19 were also recorded. Results: Out of 172 women affected by COVID-19 in pregnancy, 160 women had delivered 162 newborns (2 set of twins, 12 ongoing pregnancies). In pregnant women with COVID-19, the most common symptoms were fever MESHD fever HP (54%), cough MESHD cough HP (35%), myalgia MESHD myalgia HP (17%), dyspnea MESHD dyspnea HP (12%) and diarrhea MESHD diarrhea HP (4%). Pneumonia MESHD Pneumonia HP was diagnosed by CT scan imaging in 100 % of COVID-19 pregnant women. Pregnancy complications MESHD included delivery by cesarean section (89%), preterm labor (21%), fetal distress MESHD fetal distress HP (9%) and premature rupture of membranes HP rupture MESHD of membranes (8%). The most common co-morbidities associated with pregnant women with COVID-19 were diabetes (11%), hypertensive disorders (9%), placental disorders (5%), co- infections MESHD (6%), scarred HP uterus (5%), hypothyroidism MESHD hypothyroidism HP (5%) and anemia MESHD anemia HP (4%). Amongst the neonates of COVID-19 mothers, preterm birth (23%), respiratory distress HP syndrome MESHD (14%), pneumonia MESHD pneumonia HP (14%) low birth weight MESHD (11%), small for gestational age HP age TRANS (3%) were reported. There was one still birth and one neonatal death MESHD reported. Vertical transmission TRANS rate of SARS-CoV-2 is estimated to be 11%. Conclusion In pregnant women with COVID-19, diabetes and hypertensive disorders are common co-morbidities and there is a risk of preterm delivery. Amongst the neonates born to mothers with COVID-19, respiratory distress HP syndrome MESHD and pneumonia MESHD pneumonia HP are common occurrence. There is an evidence of vertical transmission TRANS of SARS-CoV-2 infection MESHD in women with COVID-19.

    The Disruption of SARS-CoV-2 RBD/ACE-2 Complex by Ubrogepant Is Mediated by Interface Hydration

    Authors: Olaposi Omotuyi; Oyekanmi Nash; Bashiru Ajiboye; Damilohun Metibemu; Babatunji Oyinloye; Ayodeji Ojo; kunle Okaiyeto

    id:10.20944/preprints202003.0466.v1 Date: 2020-03-31 Source:

    Background: COVID-19, caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) is a global pandemic affecting approximately 490,000 people and accounting for more than 22,000 deaths MESHD and has no generally acceptable cure. Here, the recently resolved 3D structure of SARS-CoV-2 receptor binding domain (RBD) in complex with its receptor-the angiotensin converting enzyme-2 (ACE-2) have provided the basis for screening chemical database for novel entry inhibitors. Methods: Molecular docking protocols have been used to rapidly screen FDA database for high affinity interaction at the SARS-CoV-2-RBD/ACE-2 interface. One of the top candidates, ubrogepant has been selected and further studied using atomistic molecular dynamics simulation method. Results: Molecular docking result showed that ubrogepant (UBR) and darunavir have binding energies of -10.4 kcal/mol. MMPBSA free energy analyses of UBR bound to RBD, ACE-2 and RBD/ACE-2 revealed RBD/ACE-2 > ACE-2 > RBD preference. Network analysis showed that interaction captured in the crystal structure were disrupted in UBR-bound state, hydration of the interface and increased atomic fluctuation within the RBD oligomerization interface and ACE-2 zinc binding site. Conclusions: The ability of ubrogepant to rupture MESHD the interaction at the RBD/ACE-2 interface residues of SARS-CoV-2 RBD/ACE-2 complex may result in loss of protein function with direct implication on oligomerization formation in RBD and loss of function in ACE-2 thus, making binding, cellular receptor recognition impossible. General Significance: Ubrogepant represents a new therapeutic candidate in the fight against COVID-19, as it binds with relatively high affinity with free RBD, ACE-2 receptor and SARS-CoV-2 RBD/ACE-2 complex based on binding affinity calculations.

    Misfortune never comes singly - the first case of COVID-19 with rupture MESHD of thoracic aortic aneurysm MESHD thoracic aortic aneurysm HP

    Authors: Kun Zhao; Zhang Cao; Changju Zhu; Yi Zhang; Feifan Chen

    doi:10.21203/ Date: 2020-03-25 Source: ResearchSquare

    Background: SARS-CoV-2 is a newly discovered virus, leading COVID-19 a global threaten nowadays. Case Presentation: The first case of a patient with a thoracic aortic aneurysm MESHD thoracic aortic aneurysm HP (TAA) that became infected with severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) was reported here. The patient died suddenly from a ruptured MESHD aorta 19 h after hospital admission. Conclusion: COVID-19 patients with TAA should attract the highest vigilance as COVID-19 might expedite the process of TAA rupture MESHD through cytokine storm syndrome MESHD, leading to rapid death MESHD with little or no warning signs.

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MeSH Disease
Human Phenotype

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