Corpus overview


MeSH Disease

Shock (55)

Disease (20)

Infections (14)

Death (12)

Syndrome (11)

Human Phenotype


    displaying 1 - 10 records in total 55
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    Single-cell RNA-seq reveals profound monocyte changes in Paediatric Inflammatory Multisystem Syndrome MESHD Temporally associated with SARS-CoV-2 infection MESHD (PIMS-TS)

    Authors: Eleni Syrimi; Eanna Fennell; Alex Richter; Pavle Vrljicak; Richard Stark; Sascha Ott; Paul G Murray; Eslam Al-abadi; Ashish Chikermane; Pamela Dawson; Scott Hackett; Deepthi Jyothish; Hari Krishnan Kanthimathinathan; Sean Monaghan; Prasad Nagakumar; Barnaby R Scholefield; Steven Welch; Pamela Kearns; Graham Taylor

    doi:10.1101/2020.08.06.20164848 Date: 2020-08-07 Source: medRxiv

    Paediatric inflammatory multisystem inflammatory syndrome MESHD temporally associated with SARS-CoV-2 infection MESHD (PIMS-TS) is a new disease MESHD with overlapping features of Kawasaki disease MESHD (KD) and toxic shock MESHD shock HP syndrome MESHD. Unbiased single cell RNA sequencing analysis of peripheral blood SERO mononuclear cells from PIMS-TS and KD patients shows monocytes are the main source of pro-inflammatory cytokines and large changes in the frequency of classical, intermediate and non-classical monocytes occur in both diseases MESHD.

    Firm-level immunity to COVID-19 induced uncertainty

    Authors: Sahil Narang; Savita Rawat; Rudra Prakash Pradhan

    doi:10.21203/ Date: 2020-08-04 Source: ResearchSquare

    The paper investigates the stock market response to COVID-19 induced financial uncertainty and the role of pre- shock MESHD shock HP firm-specific characteristics in shaping such stock market behaviour using a sample of S&P BSE 500 companies. Initially, the stock market experiences a significant downfall due to COVID-19 induced uncertainty; although, the market appears to rebound after a major setback. Downfall and recovery are quite surprising as downfall happened when cases were extremely small in number and there was no nation-wide lockdown announcement yet. Recovery happened when strict lockdowns were enforced and cases were rising significantly. Stock market reaction were heterogeneous among industries and various firm characteristics. On closer analysis, we find that some firms are more resilient to COVID-19 shock MESHD shock HP than others. Our analysis reveals that the most affected were small-sized, high beta, loser, and low-profitability firms as indicated by univariate analysis. The multivariate analysis finds momentum, profitability, beta, market capitalization, age TRANS, and book-to-market ratio to be the major determinants of cross-sectional CARs during downfall & recovery period. The study provides evidence of the negative reaction to COVID-19 induced uncertainty and subsequent recovery. We concludes that pre-COVID firm-specific factors play an essential role in explaining the variation in the stock market reaction to COVID-19 induced uncertainty. 

    Intravenous immunoglobulin treatment for patients with severe COVID-19: a retrospective multi-center study

    Authors: Jiao Liu; Yizhu Chen; Ranran Li; Xuan Dong; Yizhong Li; Qianghong Xu; Huibin Feng; Sisi Huang; Jun Guo; Lidi Zhang; Xiaofei Ye; Wei Zhu; Hangxiang Du; Yong’an Liu; Tao Wang; Limin Chen; Zhenliang Wen; Jean-Louis Teboul; Dechang Chen

    doi:10.21203/ Date: 2020-08-01 Source: ResearchSquare

    Background: Intravenous immunoglobulin (IVIG) is commonly used to treat severe COVID-19, although the clinical outcomes remain unclear. This study evaluated the effectiveness of IVIG treatment for severe COVID-19.Methods: This retrospective multi-center study evaluated 28-day mortality and time for SARS-CoV-2 RNA clearance in severe COVID-19 patients with or without IVIG treatment. Propensity score matching was used to control confounding factors. Logistic regression and competing risk analyses were performed.Results: The study included 850 patients (421 patients received IVIG). No significant differences in 28-day mortality or time for SARS-CoV-2 RNA clearance were observed (p=0.357 and p=0.123, respectively). High-dose of IVIG treatment (>10 g/day) (n=27) was associated with decreased 28-day mortality (OR: 0.33, 95% CI: 0.14–0.77; p=0.011). The IVIG group had prolonged median hospitalization, less shock MESHD shock HP, and higher incidences of acute respiratory distress HP syndrome MESHD, myocardial injury. Furthermore, IVIG-treated patients were more likely to require non-invasive mechanical ventilation and less likely to require invasive mechanical ventilation.Conclusions: IVIG treatment for severe COVID-19 patients was not associated with significant improvements in 28-day mortality or time for SARS-CoV-2 RNA clearance. However, some improvements in 28-day survival were observed for high-dose IVIG treatment (>10 g/day).

    Clinical features and disease MESHD severity in an Iranian population of COVID-19 patients

    Authors: Shima Nabavi; Zahra Javidarabshahi; Abolghasem Allahyari; Mohammad Ramezani; Mohsen Seddigh-Shamsi; Sahar Ravanshad; Mina AkbariRad; Farnoosh Ebrahimzadeh; Shohre Khatami; Maryam Emadzadeh; Neda Saeedian; Ahmadreza Zarifian; Maryam Miri; Fariba Rezaeetalab; Sepide Hejazi; Reza Basiri; Mahnaz Mozdourian

    doi:10.21203/ Date: 2020-07-31 Source: ResearchSquare

    Objectives: Coronavirus disease MESHD 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease MESHD may be associated with several factors. Here, we review clinical features of COVID-19 patients with different severities.Methods: This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease MESHD severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P<0.05 was considered statistically significant.Results: Overall, 200 patients with mean age TRANS of 69.75±6.39 years, of whom 82 (41%) were female TRANS were studied. Disease MESHD was severe/critical in the majority of patients (167, 83.5%). Disease MESHD severity was significantly associated with age TRANS, malignant comorbidities, dyspnea MESHD dyspnea HP, nausea MESHD nausea/vomiting HP/ vomiting MESHD, confusion MESHD confusion HP, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum SERO C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P<0.05). Moreover, complications including shock MESHD shock HP, coagulopathy, acidosis MESHD acidosis HP, sepsis MESHD sepsis HP, acute respiratory distress HP syndrome MESHD (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities. O2 saturation, nausea MESHD nausea/vomiting HP/ vomiting MESHD, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR=0.342, 45.93, and 25.48, respectively; P<0.05).Conclusions: Our results indicate O2 saturation, nausea MESHD nausea/vomiting HP/ vomiting MESHD, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum SERO CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors as possible predictors of severe disease MESHD in COVID-19 patients.

    Modelling long Range Dependence and Non-linearity in the Covid-19 Mortality Rates

    Authors: Ismail O. Fasanya; Oluwasegun B. Adekoya; Oluwatomisin Oyewole; Jones O. Mensah

    doi:10.21203/ Date: 2020-07-30 Source: ResearchSquare

    This paper relates to allaying the global fear on the persistence of the mortality rates due to the outbreak of the current COVID-19. This study thus uses the fractional integration techniques to examine the degree of persistence in the COVID-19 mortality rates for the global data and six high-risk countries, namely China, France, Italy, Spain, the United Kingdom and the United States. We find evidence in favour of mean reversion for the global mortality rates in all cases, except Italy and Spain where anti-persistence is observed. The reversion is expected to be faster for the United States followed by France. This means that the effects of the shocks MESHD shocks HP caused by the pandemic on mortality rates will recover automatically by themselves in the countries where mean reversion is noticed. Therefore, we suggest that, in addition to the global strive for medical breakthrough over the virus, other current policies, including social distancing, frequent hand sanitization, appropriate regional lockdowns, etc. introduced by most of these countries are important in drastically reducing the number of contacts with the virus. This will consequently have decreasing effects on mortality rates, and then ensure fast rate of reversion. 

    The COVID-19 Process and the Exchange Rate Relation: An Application on Turkey

    Authors: Eda Dineri; İbrahim Çütçü

    doi:10.21203/ Date: 2020-07-25 Source: ResearchSquare

    The recent shocks MESHD shocks HP in supply and demand in the world are not due to unexpected economic reasons; in fact, they are related to Covid-19 that causes rapidly spreading global health problems and life threats around the world. While the global powers are dealing with the social problems created by Covid-19 pandemic, they should not neglect the economic changes created by this pandemic. The most important of these economic changes in developing countries with high fragility is exchange rates, because exchange rates can directly affect many macroeconomic variables, from inflation to foreign trade, from the balance of payments to interests. In countries with high fragility due to the effect of pandemic, economic uncertainty causes fluctuations in the exchange rate. Is the reason for the change in the exchange rate, the number of cases or economic risks that may occur due to possible health problems?In this study, the impact of the number of new cases and the number of new deaths MESHD for the process of Covid-19 pandemic on the exchange rate in Turkey is examined. The daily data consider the number of new cases, the number of new deaths MESHD and exchange rate for the period of 16.03.2020–06.05.2020. The first step of the analysis, the stationary of the series is tested by Lee and Strazicich (2003) unıt root test which allowed structural break. Hatemi-J (2008) Cointegration Test that allow two structural breaks and Hacker-Hatemi-J Bootstrap causality test are used in the analysis. In the results of the Hatemi- J (2008) cointegration test, there is a medium and long-term relationship, with under structural breaks between the number of new cases and the number of new deaths MESHD and the exchange rate. According to the results of the analysis, it can be concluded that the number of new cases and the number of new deaths MESHD have a significant effect on the exchange rate, causing uncertainty in the economy.JEL Classification: I19, F31, C22

    (Unintended) Consequences of export restrictions on medical goods during the Covid-19 pandemic

    Authors: Marco Grassia; Giuseppe Mangioni; Stefano Schiavo; Silvio Traverso

    id:2007.11941v1 Date: 2020-07-23 Source: arXiv

    In the first half of 2020, several countries have responded to the challenges posed by the Covid-19 pandemic by restricting their export of medical supplies. Such measures are meant to increase the domestic availability of critical goods, and are commonly used in times of crisis. Yet, not much is known about their impact, especially on countries imposing them. Here we show that export bans are, by and large, counterproductive. Using a model of shock MESHD shock HP diffusion through the network of international trade, we simulate the impact of restrictions under different scenarios. We observe that while they would be beneficial to a country implementing them in isolation, their generalized use makes most countries worse off relative to a no-ban scenario. As a corollary, we estimate that prices increase in many countries imposing the restrictions. We also find that the cost of restraining from export bans is small, even when others continue to implement them. Finally, we document a change in countries' position within the international trade network, suggesting that export bans have geopolitical implications.

    Tracking the global reduction of marine traffic during the COVID-19 pandemic

    Authors: David March; Kristian Metcalfe; Joaquín Tintoré; Brendan Godley

    doi:10.21203/ Date: 2020-07-21 Source: ResearchSquare

    The COVID-19 pandemic has resulted in unparalleled global impacts on human mobility. In the ocean, ship-based activities are thought to have decreased due to severe restrictions and changes in goods consumption, but little is known of the patterns of change, which sectors are most affected, in which regions, and for how long. Here, we map global change of marine traffic during the COVID-19 pandemic and assess its temporal variability at a fine-scale in one of the most affected regions, the Mediterranean Sea. Nearly 44.3% of the global ocean and 77.5% of national jurisdictions showed a decrease in traffic density during April 2020, when strictest confinement measures took place, showing a clear disruption in comparison with previous trends and future projections. Decreases mainly occurred in coastal areas and were more marked and longer lasting in sectors other than cargo and tanker shipping. Our results provide guidance for large-scale monitoring of the progress and potential effects of COVID-19, or other global shocks MESHD shocks HP, on the blue economy and ocean health.

    The Rhythms of the Night: increase in online night activity and emotional resilience during the Covid-19 lockdown

    Authors: Maria Castaldo; Tommaso Venturini; Paolo Frasca; Floriana Gargiulo

    id:2007.09353v2 Date: 2020-07-18 Source: arXiv

    Context: The lockdown orders established in multiple countries in response to the Covid-19 pandemics are perhaps the widest and deepest shock MESHD shock HP experienced by human behaviors in recent years. Studying the impact of the lockdown, trough the lens of social media, offers an unprecedented opportunity for analyzing the susceptibility and the resilience of circadian rhythms to large-scale exogenous shocks MESHD shocks HP. In this context, we address two interconnected research questions: Can variations of online activity cycles provide information on the impact of lockdown on human activities? How do online circadian rhythms react to such a disruption? Data: We base our research on the analysis and comparison of two independent databases about the French cyberspace: a fine-grained temporal record of YouTube videos and a large collection of Tweets on {Covid-19}. Findings: In both datasets we observe a reshaping of the circadian rhythms with a substantial increase of night activity during the lockdown. The analysis of the videos and tweets published during lockdown shows a general decrease in emotional contents and a shift from themes like work and money to themes like death MESHD and safety. However, the daily patterns of emotions remain mostly unchanged, thereby suggesting that emotional cycles are resilient to exogenous shocks MESHD shocks HP.

    How does stock market reflect the change in economic demand? A study on the industry-specific volatility spillover networks of China's stock market during the outbreak of COVID-19

    Authors: Fu Qiao; Yan Yan

    id:2007.07487v1 Date: 2020-07-15 Source: arXiv

    Using the carefully selected industry classification standard, we divide 102 industry securities indices in China's stock market into four demand-oriented sector groups and identify demand-oriented industry-specific volatility spillover networks. The "deman-oriented" is a new idea of reconstructing the structure of the networks considering the relationship between industry sectors and the economic demand their outputs meeting. Networks with the new structure help us improve the understanding of the economic demand change, especially when the macroeconomic is dramatically influenced by exogenous shocks MESHD shocks HP like the outbreak of COVID-19. At the beginning of the outbreak of COVID-19, in China's stock market, spillover effects from industry indices of sectors meeting the investment demand to those meeting the consumption demands rose significantly. However, these spillover effects fell HP after the outbreak containment in China appeared to be effective. Besides, some services sectors including utility, transportation and information services have played increasingly important roles in the networks of industry-specific volatility spillovers as of the COVID-19 out broke. By implication, firstly, being led by Chinese government, the COVID-19 is successfully contained and the work resumption is organized with a high efficiency in China. The risk of the investment demand therefore was controlled and eliminated relatively fast. Secondly, the intensive using of non-pharmaceutical interventions (NPIs) led to supply restriction in services in China. It will still be a potential threat for the Chinese economic recovery in the next stage.

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MeSH Disease
Human Phenotype

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