Corpus overview


Overview

MeSH Disease

Signs and Symptoms (74)

Disease (39)

Infections (39)

Fever (34)

Cough (30)


Human Phenotype

Fever (34)

Cough (30)

Pneumonia (20)

Fatigue (14)

Lymphopenia (9)


Transmission

Seroprevalence
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    Knowledge and attitude of dentists, dental auxiliaries, and students regarding the COVID-19 pandemic in Saudi Arabia: A Cross-Sectional Survey

    Authors: Suliman Yousif Shahin; Amr Said Bugshan; Khalid Salman Almulhim; Mishali Saud AlSharief; Yousif Al Dulaijan; Faisal Dhaifallah Alqarni

    doi:10.21203/rs.3.rs-57059/v1 Date: 2020-08-10 Source: ResearchSquare

    Background: This study aimed to assess the knowledge and attitude of dental professionals in Saudi Arabia regarding severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) and coronavirus disease MESHD 2019 (COVID-19).Methods: A questionnaire was developed to assess various dental professionals from both governmental and private sectors through online and social media outlets. Results: A total of 1,033 responses were collected. Moreover, 63.4% of respondents (63.4%) were working in hospitals. Of all respondents, 44.9%, 33.4%, and 21.7% were in governmental clinics, academia, and private sector, respectively. Overall knowledge on incubation period TRANS and route of transmission TRANS of SARS-CoV-2 was satisfactory across all dental professions. All dental professionals except for dental assistants demonstrated adequate knowledge on the recommended hand-soap cleaning time (p < 0.001). Most dental professionals displayed unsatisfactory knowledge and disagreement on the survival of SARS-CoV-2 outside the host (p < 0.001). Furthermore, 75.1% of respondents were reluctant to treat a suspected COVID-19 patient, and 92% participants believed that the mode of transmission TRANS was droplet inhalation. Fever MESHD Fever HP, coughing MESHD coughing HP, and shortness of breath were identified as the most common symptoms of COVID-19. Most standard methods of prevention in the dental office were selected by at least 50% of participants. Conclusions: An appropriate level of knowledge on SARS-CoV-2 incubation period TRANS and signs and symptoms MESHD of COVID-19 was noted among all dental professionals in Saudi Arabia. Perceived survival outside the host was modest. A certain level of apprehension toward suspected SARS-CoV-2 patients existed among most professionals. Pandemic-awareness campaigns are essential among healthcare providers.

    Knowledge and attitude of dentists, dental auxiliaries and students regarding the COVID-19 pandemic in Saudi Arabia: A Cross-Sectional Survey

    Authors: Suliman Shahin; Amr Bugshan; Khalid Almulhim; Mishali AlSharief; Yousif Al-Dulaijan; Faisal al-Qarni

    doi:10.21203/rs.3.rs-53964/v1 Date: 2020-08-05 Source: ResearchSquare

    Background: This study aimed to assess the knowledge and attitude of dental professionals in Saudi Arabia regarding severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) and coronavirus disease MESHD 2019 (COVID-19).Methods: A questionnaire was developed to assess various dental professionals from both governmental and private sectors through online and social media outlets. Results: A total of 1,033 responses were collected. Moreover, 63.4% of respondents (63.4%) were working in hospitals. Of all respondents, 44.9%, 33.4%, and 21.7% were in governmental clinics, academia, and private sector, respectively. Overall knowledge on incubation period TRANS and route of transmission TRANS of SARS-CoV-2 was satisfactory across all dental professions. All dental professionals except for dental assistants demonstrated adequate knowledge on the recommended hand-soap cleaning time (p < 0.001). Most dental professionals displayed unsatisfactory knowledge and disagreement on the survival of SARS-CoV-2 outside the host (p < 0.001). Furthermore, 75.1% of respondents were reluctant to treat a suspected COVID-19 patient, and 92% participants believed that the mode of transmission TRANS was droplet inhalation. Fever MESHD Fever HP, coughing MESHD coughing HP, and shortness of breath were identified as the most common symptoms of COVID-19. Most standard methods of prevention in the dental office were selected by at least 50% of participants. Conclusions: An appropriate level of knowledge on SARS-CoV-2 incubation period TRANS and signs and symptoms MESHD of COVID-19 was noted among all dental professionals in Saudi Arabia. Perceived survival outside the host was modest. A certain level of apprehension toward suspected SARS-CoV-2 patients existed among most professionals. Pandemic-awareness campaigns are essential among healthcare providers.

    SARS-CoV-2 A Relation with Other Acute Respiratory Tract Infectious (ARTI) Diseases MESHD: A Short Communication

    Authors: HAKANI SYMPLI

    id:10.20944/preprints202008.0065.v1 Date: 2020-08-03 Source: Preprints.org

    The short study implicates few basic similarities of COVID-19 such as diseases MESHD origination, symptoms, diagnosis with other relatable viral diseases MESHD viz SARS-CoV, common Flu, pneumonia MESHD pneumonia HP etc. In the present situation, other viral diseases MESHD are frequently chaotic and misled with COVID-19 disease MESHD because of few clinical features similarities in signs and symptoms MESHD and also due to lack of specific diagnostic test. To avoid unnecessary suspects, quarantines of false positive results and to prevent the spread of COVID-19 diseases MESHD, the scientific technical research field are highly encourage to implement an efficient, rapid and sophisticated superior test for early stages of infection MESHD detection. It will be significantly convenient for physician, laboratory technicians and most importantly the common population facing a psychological disturbance.

    Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome MESHD Associated With COVID-19

    Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Mohammad Sadegh Rezai

    doi:10.21203/rs.3.rs-51157/v1 Date: 2020-07-30 Source: ResearchSquare

    Background: Although symptoms and signs MESHD of COVID-19 ( Coronavirus disease MESHD 2019) in children TRANS are milder than adults TRANS, there are reports of more severe cases which was defined as pediatric inflammatory multisystem syndrome MESHD (PIMS). The purpose of this report is to describe possible association between COVID-19 and PIMS in children TRANS.  Methods: From 28 March to 24 June 2020, 10 febrile children TRANS were admitted with COVID-19 infection MESHD showing characteristics of PIMS in a tertiary hospital in the north of Iran. Demographic and clinical characteristics, laboratory and imaging findings and therapeutic modalities were recorded and analysed. Results: The mean age TRANS of patients was 5.37±3.9 years (13 months to 12 years). Six of them were boy. Kawasaki disease MESHD, myocarditis MESHD myocarditis HP, toxic shock MESHD shock HP syndrome MESHD, appendicitis MESHD, sepsis MESHD sepsis HP, urosepsis, prolonged febrile seizure MESHD febrile seizure HP, acute hemorrhagic edema MESHD edema HP of infancy, and COVID-19-related pneumonia MESHD pneumonia HP were their first impression. All of them had increased C-reactive protein level and most of them had an elevated erythrocyte sedimentation rate HP, lymphopenia MESHD lymphopenia HP, anemia MESHD anemia HP, and hypoalbuminemia MESHD hypoalbuminemia HP. Some of them had thrombocytopenia MESHD thrombocytopenia HP. Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure and another case discharged with a giant coronary aneurysm MESHD.Conclusion: Children TRANS with COVID-19 may present symptoms similar to Kawasaki disease MESHD and inflammatory syndromes MESHD. PIMS should be considered in children TRANS with fever MESHD fever HP and rash, seizure MESHD seizure HP, cough MESHD cough HP, tachypnea MESHD tachypnea HP, and gastrointestinal symptoms such as vomiting MESHD vomiting HP, diarrhea MESHD diarrhea HP, and abdominal pain MESHD abdominal pain HP.

    The incidence, risk factors and prognosis of acute kidney injury MESHD acute kidney injury HP in severe and critically ill patients with COVID-19 in mainland China: a retrospective study

    Authors: Ling Sang; Sibei Chen; Xia Zheng; Weijie Guan; Zhihui Zhang; Wenhua Liang; Ming Zhong; Li Jiang; Chun Pan; Wei Zhang; Jiaan Xia; Nanshan Chen; Wenjuan Wu; Hongkai Wu; Yonghao Xu; Xuesong Liu; Xiaoqing Liu; Jianxing He; Shiyue Li; Dingyu Zhang; Nanshan Zhong; Yimin Li

    doi:10.21203/rs.3.rs-50431/v1 Date: 2020-07-29 Source: ResearchSquare

    Background: Since the clinical correlates, prognosis and determinants of AKI in patients with Covid-19 remain largely unclear, we perform a retrospective study to evaluate the incidence, risk factors and prognosis of AKI in severe and critically ill patients with Covid-19.Methods: We reviewed medical records of all adult TRANS patients (>18 years) with laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 and April 6th 2020 at Wuhan JinYinTan Hospital and The First Affiliated Hospital of Guangzhou Medical University. The clinical data, including patient demographics, clinical symptoms and signs MESHD, laboratory findings, treatment [including respiratory supports, use of medications and continuous renal replacement therapy (CRRT)] and clinical outcomes, were extracted from the electronic records, and we access the incidence of AKI and the use of CRRT, risk factors for AKI, the outcomes of renal diseases MESHD, and the impact of AKI on the clinical outcomes.Results: Among 210 subjects, 131 were males TRANS (62.4%). The median age TRANS was 64 years (IQR: 56-71). Of 92 (43.8%) patients who developed AKI during hospitalization, 13 (14.1%), 15 (16.3%) and 64 (69.6%) patients were classified as stage 1, 2 and 3, respectively. 54 cases (58.7%) received CRRT. Age TRANS, sepsis MESHD sepsis HP, Nephrotoxic drug, IMV and elevated baseline Scr were associated with AKI occurrence. The renal recover during hospitalization among 16 AKI patients (17.4%), who had a significantly shorter time from admission to AKI diagnosis, lower incidence of right heart failure MESHD and higher P/F ratio. Of 210 patients, 93 patients deceased within 28 days of ICU admission. AKI stage 3, critical disease MESHD, greater age TRANS and minimum P/F <150mmHg independently associated with it.Conclusions: Among patients with Covid-19, the incidence of AKI was high. age TRANS , sepsis MESHD sepsis HP, nephrotoxic drug, IMV and baseline Scr were strongly associated with the development of AKI. Time from admission to AKI diagnosis, right heart failure MESHD and P/F ratio were independently associated with the potential of renal recovery. Finally, AKI KIDGO stage 3 independently predicted the risk of death within 28 days of ICU admission.

    EPICOVID19: Psychometric assessment and validation of a short diagnostic scale for a rapid Covid-19 screening based on reported symptoms

    Authors: Luca Bastiani; Loredana Fortunato; Stefania Pieroni; Fabrizio Bianchi; Fulvio Adorni; Federica Prinelli; Andrea Giacomelli; Gabriele Pagani; Stefania Maggi; Caterina Trevisan; Marianna Noale; Nithiya Jesuthasan; Aleksandra Sojic; Carla Pettenati; Massimo Andreoni; Raffaele Antonelli Incalzi; Massimo Galli; Sabrina Molinaro

    doi:10.1101/2020.07.22.20159590 Date: 2020-07-25 Source: medRxiv

    Background Confirmed COVID-19 cases have been reported in 213 countries and regions and as of 12 July 2020, over 12 million cases, with 561617 deaths MESHD have been reported worldwide. The number of cases changes quickly and varies depending upon which source you use to track, so in the current epidemiological context, the early recognition is critical for the rapid identification of suspected cases (with SARS-CoV-2 infection MESHD-like symptoms and signs MESHD) to be immediately subjected to quarantine measures. Although surveys are widely used for identifying COVID-19 cases, outcomes and associated risks, no validated epidemiological tool exists for surveying SARS-CoV-2 infection MESHD in the population so far. Methods Our study is the phase II of the EPICOVID19 national survey, launched in April 2020 including a national convenience sample of 201121 adults TRANS, who voluntarily filled the EPICOVID19 questionnaire. The phase II questionnaire was mailed to all subjects who underwent tests for COVID-19 by nasopharyngeal swab (NPS) and who accepted to be involved in the second phase of the study, focused on the results reported for NPS and/or serological IgG/IgM tests. We evaluated the capability of the self-reported symptoms collected through the EPICOVID19 questionnaire to discriminate the COVID-19 among symptomatic subjects, in order to identify possible cases to undergo instrumental measurements and clinical examinations. We defined a method for the identification of a total score and validated it with reference to the serological and molecular clinical diagnosis, using four standard steps: identification of critical factors, confirmation of presence of latent variable, development of optimal scoring algorithm and validation of the scoring algorithm. Findings 2703 subjects [66% response rate] completed the Phase II questionnaire. Of 2703 individuals, 694 (25.7%) were NPS(+) and of these 84 (12.1% of the 694 NPS(+)) were asymptomatic TRANS. In the individuals who performed serological testing SERO, of the 472 who did IgG(+) and 421 who did IgM(+), 22.9% and 11.6% tested positive, respectively. Among IgG(+) 1 of 108 subjects was asymptomatic TRANS (0.9%) while 5/49 subjects among IgM(+) were asymptomatic TRANS (10.2%). Compared with NPS(-), among NPS(+) subjects there was a higher rate for Fever MESHD Fever HP (421 [60.7%] vs 391[19.5% ]; p<0.0001), Loss of Taste and/or Smell (365 [52.6%] vs 239 [11.9% ]; p<0.0001) and Cough MESHD Cough HP (352 [50.7%] vs 580 [28.9% ]; p<0.0001). Also for other symptoms the frequencies were significantly higher in NPS(+) subjects than in NPS(-) ones (p<0.001). Among groups with serological tests SERO, the symptoms with higher percentages in the subjects IgG(+) were Fever MESHD Fever HP (65 [60.2%] vs 43[11.8% ]; p<0.0001) and Pain MESHD Pain HP in muscles, bones, joints (73 [67.6%] vs 71 [19.5% ]; p<0.0001). For the COVID-19 self-reported symptoms items, exploratory (proportion variance explained [89.9%]) and confirmatory factor analysis results (SMSR 0.072; RMSEA 0.052) highlights the presence of one latent variable (factor) underlying the symptoms. We define the one-factor solution as EPICOVID19 diagnostic scale and optimal score for each items was identified: Respiratory problems (1.03), Chest pain MESHD Chest pain HP (1.07), Loss of Taste and/or Smell (0.97) and Tachycardia MESHD Tachycardia HP ( palpitations HP) (1.05) were the most important symptoms. The cut-off score was 2.56 ( Sensitivity SERO 76.56%; Specificity 68.24%) in NPS(+) and 2.59 (Se 80.37; Sp 80.17) in IgG(+) subjects.

    COVID-19, What Could Sepsis MESHD Sepsis HP, Severe Acute Pancreatitis HP Pancreatitis MESHD, Gender TRANS Differences and Aging Teach Us?

    Authors: Claudio Gallo; Sirio Fiorino; Giovanni Posabella; Donato Antonacci; Antonio Tropeano; Emanuele Pausini; Carlotta Pausini; Tommaso Guarniero; Marco Zancanaro

    id:202007.0414/v1 Date: 2020-07-19 Source: Preprints.org

    Severe COVID-19 disease MESHD is characterised by an exaggerated inflammatory response, called cytokine storm, accompanied by a condition of immune depression. Even sepsis MESHD sepsis HP is characterised by an exaggerated inflammatory response, called SIRS ( Systemic Inflammatory Response Syndrome MESHD), accompanied by a condition of immune depression called CARS (compensatory anti-inflammatory response syndrome MESHD). Clinical studies reveal that most sepsis MESHD sepsis HP patients who did not die during the hyper inflammatory response (SIRS) subsequently succumbed to the condition of immune depression (CARS). Severe acute pancreatitis HP pancreatitis MESHD begins with local inflammation MESHD that induces systemic inflammatory response syndrome MESHD (SIRS), accompanied and followed by a compensatory anti-inflammatory response (CARS). In COVID-19 disease MESHD, the male TRANS response to SARS CoV-2 virus is typically characterised by a robust inflammatory response. Instead, a cell-mediated immune response is dominant in women. This means that the male TRANS sex tends to have a more robust hyper inflammatory response than the female TRANS one. Furthermore, in women the condition of immune depression is less represented, therefore they are more protected. Sepsis MESHD Sepsis HP, severe acute pancreatitis HP pancreatitis MESHD and COVID-19 disease MESHD evolve between two fundamental aspects: hyper inflammation MESHD and immunodepression. The experience gained over years of studies of sepsis MESHD sepsis HP and severe acute pancreatitis HP pancreatitis MESHD suggests that therapies should be differentiated according to the evolutionary stage of the disease MESHD. The goal is to save the lives of most patients with COVID-19 disease MESHD. The identification of critical points, suitable for designing the windows of therapeutic opportunity, may allow the use of therapeutic interventions, in the COVID-19 disease MESHD, which are effective (there are no approved drugs yet), safe (without significant side effects), targeted (based on the evolutionary phase of the disease MESHD) personalized, (based on sex, co-morbidities, age TRANS, etc.) and timely (based on signs, symptoms MESHD, laboratory parameters and instrumental investigations).

    Serological Cytokine and chemokine profile in pregnant women with COVID19 in Mexico City

    Authors: Arturo Cerbulo-Vazquez Sr.; Berenice Zavala-Barrios; Jesus Carlos Briones-Garduno; Guadalupe Mercedes Lucia Guerrero-Avendano; Lourdes Arriaga-Pizano; Eduardo Ferat-Osorio; Graciela Libier Cabrera-Rivera; Patricia Miranda-Cruz; Maria Teresa Garcia de la Rosa; Jessica Lakshmi Prieto-Chavez; Vanessa Rivero-Arredondo; Ruth Madera-Sandoval; Alonso Cruz-Cruz; Enrique Salazar-Rios; David Serrano-Molina; Roberto De Lira-Barraza; Abel Humberto Villanueva-Compean; Alejandra Esquivel-Pineda; Ruben Ramirez-Montes de Oca; Guillermo Flores-Padilla; Constantino Lopez-Macias

    doi:10.1101/2020.07.14.20153585 Date: 2020-07-17 Source: medRxiv

    On January 30th, 2020, the WHO declared the outbreak of COVID19, a disease MESHD due to the new coronavirus called SARS-CoV-2. Certain comorbidities, symptoms and signs MESHD are characteristic of COVID19 in the general population and in pregnant women. However, pregnant women are considered as a high-risk group for COVID19. To know about the frequency of comorbidities, signs and symptoms MESHD, the presence of lymphopenia MESHD lymphopenia HP, antibodies SERO response to SARS-CoV2 and cytokine and chemokine serum SERO concentration, six pregnant women with COVID19 were studied at the moment of admission. The lower concentration of CCL17 was detected in the Pregnant COVID19 group, similar concentration of IL-6 was also detected in non-pregnant and pregnant COVID19 patients. Our result show that pregnant and non-pregnant women with COVID19 has similar cytokine profile.

    COVID-19 SignSym: A fast adaptation of general clinical NLP tools to identify and normalize COVID-19 signs and symptoms MESHD to OMOP common data model

    Authors: Jingqi Wang; Huy Anh Pham; Frank Manion; Masoud Rouhizadeh; Yaoyun Zhang

    id:2007.10286v1 Date: 2020-07-13 Source: arXiv

    The COVID-19 pandemic swept across the world rapidly infecting millions of people. An efficient tool that can accurately recognize important clinical concepts of COVID-19 from free text in electronic health records will be significantly valuable to accelerate various applications of COVID-19 research. To this end, the existing clinical NLP tool CLAMP was quickly adapted to COVID-19 information and generated an automated tool called COVID-19 SignSym, which can extract and signs/symptoms MESHD and their eight attributes such as temporal information and negations from clinical text. The extracted information is also mapped to standard clinical concepts in the common data model of OHDSI OMOP. Evaluation on clinical notes and medical dialogues demonstrated promising results. It is freely accessible to the community as a downloadable package of APIs (https://clamp.uth.edu/covid/nlp.php). We believe COVID-19 SignSym will provide fundamental supports to the secondary use of EHRs, thus accelerating the global research of COVID-19.

    COVID-19 Pandemic and Dental Hygienists in Italy: A Questionnaire Survey.

    Authors: Giuliana Bontà; Guglielmo Giuseppe Campus; Maria Grazia Cagetti

    doi:10.21203/rs.3.rs-42102/v1 Date: 2020-07-13 Source: ResearchSquare

    Backgroud: This survey assesses the signs/symptoms MESHD, the protective measures taken and the awareness and risk perception regarding COVID-19 among Italian dental hygienists. All Italian dental hygienists were invited to participate. The online ad hoc questionnaire was divided into four domains: personal data, protective measures (-before patient arrival; -in the waiting room; -in the operating room) and PPE, awareness and risk perception. Results: Two-thousand-seven-hundred-ninety-eight subjects participated. Only 0.25% of the sample was positive to the virus. Sense of fatigue MESHD fatigue HP (8.19%), headache MESHD headache HP (7.81%) and sore throat (7.32%) were the most common symptoms. A statistically significant trend across the areas with a different prevalence SERO of COVID-19 was observed related to the number of signs/symptoms MESHD (areas z=6.38 p<0.01). Overall, 90.55% of the sample used protective glasses or visor, 90.10% disposable gloves and 82.80% surgical mask. Regarding the confidence to avoid the infection MESHD, a statistically significant difference was found among dental hygienists belong to the three years-professional-experiences groups who worked in the high COVID-19 prevalence SERO area. The findings of this survey show that Italian dental hygienists have modified their working habits according to the professional risk related to the current pandemic and they seem correctly prepared to face the SARS-CoV-2 infection MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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