Coronavirus Disease MESHD 2019 (COVID-19), caused by a novel coronavirus named Severe Acute Respiratory Syndrome MESHD - Coronavirus-2 (SARS-CoV-2), emerged in early December 2019 in China and attained a pandemic situation worldwide by its rapid spread to nearly 167 countries with 287.239 confirmed cases TRANS and 11.921 human deaths MESHD with a case fatality rate (CFR) of around 4 per cent. Bats were considered as the reservoir host, and the search of a probable intermediate host is still going on. Animals have anticipated culprit of SARS-CoV-2 as of now. The disease MESHD is mainly manifested by pneumonia MESHD pneumonia HP and related respiratory signs and symptoms MESHD, but the involvement of the gastrointestinal system and nervous system is also suggested. The severe form of the disease MESHD associated with death MESHD is mainly reported in older and immune-compromised patients with pre-existing disease MESHD history. Death MESHD in severe cases is attributed to respiratory failure HP associated with hyperinflammation. Cytokine storm syndrome MESHD associated with rampant inflammation MESHD in response to SARS-CoV-2 infection MESHD is considered as the leading killer of COVID-19 patients. COVID-19 patients were reported with higher levels of many pro-inflammatory cytokines and chemokines like IFN-g, IL-1b, IP-10, and MCP-1. Furthermore, severe cases of COVID-19 revealed higher levels of TNF-α, G-CSF, and MIP-1A. Blood SERO profile of the COVID-19 patients exhibits lymphopenia MESHD lymphopenia HP, leucopenia, thrombocytopenia MESHD thrombocytopenia HP and RNAaemia along with increased levels of aspartate aminotransferase. SARS-CoV-2 infection MESHD in pregnant women does not lead to fetus mortalities unlike other zoonotic coronaviruses like SARS-CoV and MERS-CoV, with no evidence of intrauterine transmission TRANS to neonates. Rapid and confirmatory diagnostics have been developed, and high efforts are being made to develop effective vaccines and therapeutics. In the absence of any virus-specific therapeutic, internationally health care authorities are recommending adoption of effective prevention and control measures to counter and contain this pandemic virus. This paper is an overview of this virus and the disease MESHD with a particular focus on SARS-COV-2 / COVID-19 clinical pathology, pathogenesis and immunopathology along with a few recent research developments.