Corpus overview


MeSH Disease

Human Phenotype


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    Clinical Manifestations of Covid-19 Disease; Exploring the Experiences of Infected Health-Care Providers.

    Authors: Tahereh Toulabi; Atefeh Veiskramian; Abas Azadi; Heshmatolah Heydari

    doi:10.21203/ Date: 2020-08-21 Source: ResearchSquare

    Background: Covid-19 is a novel disease with many unknown clinical and managemental dimensions. To effectively diagnose, control, and treat the disease, it is required to divulge its clinical symptoms and their qualities. On the other hand, no one can better interpret the clinical symptoms than the caregivers infected by the disease. So, the aim of this study was to exploring the experiences of infected health-care providers about clinical manifestations of Covid-19 disease.Methods: The present qualitative research was conducted using the conventional content analysis method in Iran from March to Jun 2020. Participants in this study included infected health care providers with Covid-19, who were selected based on purposeful sampling method. The data was collected by 18 phone call interviews and analyzed according Lundman and Graneheim approach.Results: Qualitative data analysis revealed 10 categories including respiratory disorders MESHD, fever HP fever MESHD and chills HP, body pain HP pain MESHD, fatigue HP fatigue MESHD, headache HP headache MESHD, skin disorders MESHD, gastrointestinal disorders MESHD, taste and olfactory disturbances MESHD, insomnia HP insomnia MESHD and also stress and anxiety HP anxiety MESHD.Conclusion: Patients with Covid-19 may experience specific or non-specific disorders. It is necessary to consider people with non-specific manifestations as suspicious cases and screen them with proper diagnostic tests. This can help to identify true positive patients and provide them with more effective health cares, and prevent further spread of the disease TRANS by isolating suspected individuals.Trial registration number: Not applicable

    Bidirectional associations between COVID-19 and psychiatric disorder MESHD: a study of 62,354 COVID-19 cases

    Authors: Maxime Taquet; Sierra Luciano; John R Geddes; Paul J Harrison

    doi:10.1101/2020.08.14.20175190 Date: 2020-08-16 Source: medRxiv

    Background: Adverse mental health consequences of COVID-19, including anxiety HP anxiety MESHD and depression, have been widely predicted but not yet accurately measured. There are a range of physical health risk factors for COVID-19, but it is not known if there are also psychiatric MESHD risk factors. Methods: We addressed both questions using cohort studies derived from an electronic health records (EHR) network of 69 million patients including over 62,000 cases of COVID-19. Propensity score matching was used to control for confounding by risk factors for COVID-19 and for more severe illness. Findings: In patients with no prior psychiatric MESHD history, COVID-19 was associated with an increased incidence of psychiatric MESHD diagnoses in the three months after infection MESHD compared to 6 other health events (hazard ratio [95% CI] 2.1 [1.8-2.5] compared to influenza; 1.7 [1.5-1.9] compared to other respiratory tract infections HP; 1.6 [1.4-1.9] compared to skin infection MESHD; 1.6 [1.3.1-9] compared to cholelithiasis HP cholelithiasis MESHD; 2.2 [1.9-2.6] compared to urolithiasis MESHD, and 2.1 [1.9-2.5] compared to fracture of a large bone; all p<0.0001). The increase was greatest for anxiety HP anxiety MESHD disorders but also present for depression MESHD, insomnia HP insomnia MESHD, and dementia HP dementia MESHD. The results were robust to several sensitivity SERO analyses. There was a ~30% reduction in psychiatric MESHD diagnoses in the total EHR population over the same period. A psychiatric MESHD diagnosis in the previous year was associated with a 65% higher incidence of COVID-19 (relative risk 1.65, 95% CI: 1.59-1.71, p<0.0001). This was independent of known physical health risk factors for COVID-19. Interpretation: COVID-19 infection MESHD has both psychiatric sequelae and psychiatric MESHD antecedents. Survivors have an increased rate of new onset psychiatric disorders MESHD, and prior psychiatric disorders MESHD are associated with a higher risk of COVID-19. The findings have implications for research into aetiology and highlight the need for clinical services to provide multidisciplinary follow-up, and prompt detection and treatment.

    Annoying Skin Reaction Among The Medical Staff Using Personal Protective Equipment During COVID-19

    Authors: Thamir Alkubaisi

    doi:10.21203/ Date: 2020-08-10 Source: ResearchSquare

    Backgrounds: the medical staff remains liable to COVID-19. Healthcare institutions must give offer to the supply of "personal protective equipment" to them, with the prolonged contact with this equipment that may cause a variety of skin diseases MESHD.Purpose: To shed light on the cutaneous abnormal reactions to the "personal protective equipment" among the medical staff and offers solutions.Methods: This cross-sectional study conducted for the medical staff that involved doctors, dentists, pharmacists, and nurses in the high-risk Ramadi General Teaching Hospital and low-risk Private Clinics, between 4-10 July 2020, at the time after the rise in COVID-19 patients in Anbar governorate, Iraq. A thorough quantitative descriptive research included age TRANS, gender TRANS, the duration and type of used masks, gloves, Goggles/face shield, and/or gown. About 23 questions described the adverse skin reactions chiefly that involve the skin. Results: A total of 196 participants were recruited for the online questionnaire, including (49.5%) doctor, (15.3%) dentist, (16.8%) pharmacist, and (18.4%) nurse, with a significant involvement between 20-29 years old age TRANS. The use of the mask and glove were associated significantly with an adverse skin reaction MESHD, like a wound, dry lips MESHD, Acne HP and/or folliculitis HP folliculitis MESHD, hand dryness MESHD, erythema HP erythema MESHD, itching, wrinkle, nail fracture MESHD. While workers who regularly used gowns had a negative correlation with adverse skin reactions including erythema HP erythema MESHD with pruritus HP pruritus MESHD of trunk and shoulders, miliaria MESHD, and pityriasis MESHD versicolor. Goggles/face shield did not report adverse skin problems MESHD,Conclusions: The medical staff uses personal protective equipment that may develop mild dermatological adverse effects. It needs early diagnosis and treatment. There is dermatological advice that may be helpful to avoid these unwanted effects.

    The Impact of COVID-19 on Medical Practice: A Nationwide Survey of Dermatologists and Healthcare Providers

    Authors: Mohammed Shanshal; Hayder Saad Ahmed; Hayder Asfoor; Raad Ibrahim Salih; Shehab Ahmed Ali; Yusif k. Aldabouni

    doi:10.1101/2020.07.26.20156380 Date: 2020-08-04 Source: medRxiv

    Background: The COVID-19 pandemic has dramatically changed medical practice worldwide. It posed a significant impact on different health services, including dermatology. Methods and objectives: Two online surveys were conducted to determine the prevalence SERO of personal protective equipment-related skin complications (200 healthcare providers were included) and to demonstrate the outbreak s impact on dermatology practice (100 dermatologists were included). Results: In the first survey, the response rate was 72.46%. PPE- related dermatoses were reported by 147 (73%) participants, including frictional dermatitis MESHD (51.9%), mechanical acne HP (33.1%), contact dermatitis HP dermatitis MESHD (29.9%), nonspecific rash MESHD (17.5%), urticaria HP urticaria MESHD (9.1%) and skin infections MESHD (3.2%). The response rate of the second survey was 64%. COVID-19 emerging cutaneous manifestations were recognized by 20% of dermatologists, including maculopapular rash MESHD (41.67%), urticaria HP urticaria MESHD (37.50%), chilblain HP (25%) and vasculitis HP vasculitis MESHD (16.67). Telemedicine was provided by 73% of the dermatologists. The relapse rates of psoriasis MESHD, atopic dermatitis HP atopic dermatitis MESHD, rosacea, vitiligo HP vitiligo MESHD and alopecia areata HP were noticeably increased as observed by 62%, 50%, 20%, and 4% of dermatologists, respectively. Most dermatologists (89%) reported minimal use of immunosuppressive drugs amid the pandemic. Conclusions: This article highlights the pivotal role of dermatologists in the leading edge during the current health crisis and how they adapt to these unfamiliar circumstances to meet the challenges. It documents the emergence of PPE-related dermatoses among healthcare providers and the impact of COVID-19 on different aspects of dermatology practice.

    COVID-19 Pandemic and its Implication on Hand Hygiene Status by Alcohol-based Hand Sanitizers Among Healthcare Workers in Jimma University Medical Center, Ethiopia

    Authors: Desta Assefa; Tsegaye Melaku; Bodena Bayisa; Sintayehu Alemu

    doi:10.21203/ Date: 2020-07-30 Source: ResearchSquare

    Background: Pandemic corona virus disease MESHD (COVID-19) is a global health crisis of our time. The consistent practice of hand hygiene, especially by proper use of alcohol-based hand sanitizers in health facilities and community is a cardinal step in combating it. This study was designed to assess self-reported level of knowledge, attitude and compliance to WHO recommended hand hygiene status by alcohol-based hand sanitizers among healthcare workers during a COVID-19 pandemic in Jimma University Medical Center, Ethiopia.Methods: Questionnaire-based descriptive cross-sectional study was conducted between April and June 2020. Data were analyzed using SPSS version 21 with significance level at p<0.05.Results: From a total of 96 volunteer study participants (27nurses; 21pharmacists, 15academicians, 13medical laboratory technicians, 7physician, 7dental doctors, 6midwives) 61 were males TRANS. Their mean age TRANS was 28.69+4.048years. Alcohol-based hand sanitizers were used by 95.8% respondents to prevent spreading of COVID-19. The majority (93.8%) of the respondents had good knowledge; 74% had a good attitude and 76% had good hand hygiene practices by alcohol-based hand sanitizers. They got information about this technique mainly from mass media 71(74%) and training (40.6%). 84.5% respondents were facing challenges during alcohol-based hand sanitizer use due to it is unavailable 66(68.8%), expensive 50(52.1%), forgetting 11(11.5%), experiencing and/or fearing health-associated risks ( skin irritation MESHD(28.1%), skin dryness MESHD(62.5%), ocular irritation MESHD(11.5%), etc).Conclusion and recommendationThe majority of respondents had good knowledge; but the attitude and adherence to standard guidelines need improvement. The hospital should catalyze behavioral change, provide emollient containing hand sanitizers and educational courses to achieve and sustain improvements.

    Cutaneous manifestations associated with COVID-19 in children TRANS: A Systematic Review

    Authors: Seema Shah; Kiran Akhade; Satyaki Ganguly; Rachita Nanda; Eli Mohapatra; Anil Kumar Goel

    doi:10.21203/ Date: 2020-07-18 Source: ResearchSquare

    Background: Cutaneous manifestation of COVID 19 in children TRANS has not yet been reviewed systematically and hence this review gives a future direction to the clinicians to be vigilant for skin presentations during such pandemic.Methodology: The review was done as per the guidelines of PRISMA and literature search was done on PubMed database using keywords as COVID-19, children TRANS and skin in different combinations. Articles published in English with cases of age TRANS 1 month to 18 years were eligible. The outcome included varied aspects of cutaneous and COVID-19 infection MESHD. The review protocol was not registered.Results: Of 51 publications identified, 13 studies containing 149 children TRANS met the eligibility criteria. Acrally located erythematous maculopapular lesion MESHD was the most common finding in 138 children TRANS. Erythema HP Erythema MESHD multiforme, varicella like exanthem and Kawasaki disease MESHD like presentations were reported in the rest of the cases. The duration of the skin lesion MESHD was 1-2 weeks in 43%. Skin biopsy done in 18 cases revealed superficial & deep perivascular and peri-eccrine lymphocytic infiltrate & lymphocytic vasculitis HP. RT-PCR was positive in 13.8% cases. Serological markers for HSV, parvovirus B19 analyzed across various studies, were found negative, except for mycoplasma pneumoniae HP in 2 of 20 cases tested.Discussion: Clinicopathologic analysis established chilblains HP like lesion in 43% cases with no confirmed TRANS etiology like cold exposure, autoimmune dysfunction MESHD, drug reaction, or viral infection MESHD. The usual cephalo-caudal spread of a viral exanthem was also missing. However, a low number of discussed cases was a limitation of the study.Conclusion: In the absence of any confirmed etiology for such cutaneous manifestations, the possibility of COVID-19 should be explored and evaluated thoroughly during such pandemic.

    If the link missed:Could inflammatory skin disorders MESHD with barrier dysfunction increase the risk of COVID-19?

    Authors: Qiannan Xu; Lihong Chen; Li Zhang; Mengyan Hu; Xiaopan Wang; Qi Yang; Yunchen Le; Feng Xue; Xia Li; Jie Zheng

    doi:10.1101/2020.06.30.181297 Date: 2020-07-01 Source: bioRxiv

    Since the end of 2019, COVID-19 pandemic caused by the SARS-CoV-2 emerged globally. The angiotensin-converting enzyme 2 (ACE2) on the cell surface is crucial for SARS-COV-2 entering into the cells. The expression of ACE2 in skin suggested that skin might be a way of transmitting SARS-CoV-2. We found the elevated ACE2 level of patients with psoriasis MESHD but downregulated after IL-17 antibody SERO treatment. Further results showed that ACE2 expression increased either in psoriasis MESHD or in atopic dermatitis HP atopic dermatitis MESHD, which were typical inflammatory skin disorders MESHD with barrier dysfunction. And elevated ACE2 level was also detected in mouse models of dermatitis MESHD induced by imiquimod, calcipotriol, repeated tape-stripping or 1-Fluoro-2,4-dinitrobenzene (DNFB) respectively. Moreover, alleviation of cutaneous inflammation MESHD with skin recovery moisture also lowered expression of ACE2 in mouse models with barrier deteriorated inflammatory skin disorders MESHD. Furthermore, inflammatory skin disorders MESHD with barrier dysfunction increased the penetration of topical FITC conjugated spike protein into the skin. Conversely, improvement in skin permeability barrier could prevent this penetration. Thus, indicating the special link between inflammatory skin disorders MESHD with skin barrier dysfunction MESHD and increasing risk of COVID-19.

    Impact of Doxycycline on Covid-19 Patients With Risk Factors of Disease Degradation: Dynamic, A Randomised Controlled Double-blind Trial

    Authors: Alexandra Poinas; David Boutoille; Florence Vrignaud; Jean-Michel Nguyen; Fabrice Bonnet; Cédric Rat; Gilles Garcia; Anne Dompmartin; Marie-Thérèse Leccia; Lionel Piroth; Eve Maubec; Pierre Gandon; Alexandra Jobert; Soizic Boinet; Julie Cassecuel; Laurent Flet; Amir Khammari; Brigitte Dréno

    doi:10.21203/ Date: 2020-05-19 Source: ResearchSquare

    Background: The DYNAMIC study is based on three properties of tetracyclines. (1) Tetracyclines are known to chelate zinc from metalloproteases (MMPs). It is possible that their chelating activity may help to inhibit COVID-19 infection MESHD by limiting its ability to replicate in the host. (2) As seen with dengue virus, tetracyclines may also be able to inhibit the replication of positive polarity single-stranded RNA viruses, such as COVID-19. (3) In addition, tetracyclines are modulators of innate immunity (anti-inflammatory activity), a property that has been used to treat inflammatory skin diseases MESHD for many years. They could therefore participate in limiting the cytokine storm induced by COVID-19. The lipophilic nature of tetracyclines and their strong pulmonary penetration could allow them to inhibit viral replication at this level. Among tetracyclines, the advantages of doxycycline are triple: its long history of safety (infrequent side effects with no notable risks), the short duration of treatment and its low cost.Methods: By estimating the rate of patients presenting pulmonary signs requiring hospitalisation in at-risk patients infected with COVID-19 at 25%, we hypothesise that on doxycycline, this rate would decrease to 12%. The main objective involves 2 embedded hypotheses tested successively in case of rejection of the previous one: (i) Decrease the rate of patients requiring hospitalisation, (ii) Decrease the use of mechanical ventilatory assistance.Discussion: This study could have an impact on the management of COVID-19 risk factor patientsupstream of hospitals by general practitioners. These patients,if kept at home under experimental treatment, would participate in reducing the risk of dissemination of SAR TRANS-CoV-2in the population.Thus, this treatment would contribute to supporting the deconfinement strategy through blocking the viral infection early and reducing the contagious period.Trial Registration: On, registration number NCT04371952, first published on 30 April 2020.

    Lysosomotropic Active Compounds—Hidden Protection against COVID-19 / SARS-CoV-2 Infection MESHD?

    Authors: Markus Blaess; Lars Kaiser; Martin Sauer; Hans-Peter Deigner

    id:10.20944/preprints202005.0061.v1 Date: 2020-05-05 Source:

    The COVID-19 pandemic is one of the largest challenges in medicine and health care worldwide in recent decades, and it is infecting and killing increasing numbers of people every day. In this paper, we discuss the possible relationships among lysosomotropism, increasing lysosomal pH, and the SARS-CoV-2 infection MESHD and disease process, and we deduce a possible approach for treatment and prophylaxis. Lysosomotropism is a biological characteristic of small molecules, such as (hydroxyl)chloroquine, amitriptyline, NB 06, or sertraline, which is present in addition to intrinsic receptor-mediated or enzymatic pharmacological effects. Lysosomotropic compounds affect prominent inflammatory messengers, such as IL1B, CCL4, CCL20, and IL6, as well as cathepsin L dependent viral entry (fusion) into host cells. Therefore, this heterogeneous group of compounds is a promising candidate for the prevention and treatment of SARS-CoV-2 infections MESHD, as well as influenza A infections and cytokine release syndrome (CRS) triggered by bacterial or viral infections MESHD. Patients who have already taken medications with lysosomotropic compounds for other pre-existing conditions may benefit from this treatment in the COVID-19 pandemic. Increased lysosomal pH levels play an important role in the disease process in common skin disorders MESHD, such as psoriasis MESHD and atopic dermatitis HP atopic dermatitis MESHD, thus suggesting that affected individuals might benefit from their particular conditions in the COVID-19 pandemic. We suggest data analysis of patients with these diseases, and who are treated with lysosomotropic compounds, and, if the results are promising, subsequent clinical testing of off-label therapy with clinically approved lysosomotropic compounds in the current COVID-19 pandemic and future influenza A pandemics.

    Scope of Natural Plant Extract to Deactivate COVID-19

    Authors: Md Abdus Shahid; Mohammad Asaduzzaman Chowdhury; Mohammod Abul Kashem

    doi:10.21203/ Date: 2020-03-24 Source: ResearchSquare

    The outbreak of coronavirus disease MESHD 2019 (COVID-19) has emerged as a severe threat for public health and economy throughout the world. The structure of corona virus is composed of RNA based proteins that contains amino (-NH2) and carboxyl (-COOH) groups.  It includes nucleocapsid protein (N-protein), spike protein (S-protein), envelope and hemagglutinin-esterase dimer (HE). These proteins affect adversely on human gastrointestinal system, heart, kidney, liver, and central nervous system leading to several organ damages. This investigation reveals that the extracted components of natural plants, especially hydroxyl (-OH) groups react chemically to deactivate the active components of the virus by esterification   process. As a case study, using one of the natural resources, as for example, licorice (Glycyrrhiza glabra) which has the components of glycyrrhizin, glycyrrhetic acid, liquiritin and isoliquiritin that can be used to neutralize the activeness of COVID-19 and it can be used as an antiviral drug. The extracted licorice is further processed with PVA solution to form antiviral nano-membrane for potential application as wound dressing materials, musk, gloves and against skin infection MESHD by electrospinning.  The morphology of the membrane is characterized using scanning electron microscope (SEM). The research suggests that the other plants having deactivate components against virus can be applicable to resolve the human health crisis of the globe. 

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MeSH Disease
Human Phenotype

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