Corpus overview


MeSH Disease

Human Phenotype

Anxiety (2)

Falls (1)


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    Sleepless in Lockdown: unpacking differences in sleep loss during the coronavirus pandemicin the UK

    Authors: Jane Falkingham; Maria Evandrou; Min Qin; Athina Vlachantoni

    doi:10.1101/2020.07.19.20157255 Date: 2020-07-21 Source: medRxiv

    Background: Covid-19 has been shown to be having a disproportionate impact on the health of individuals from different ethnic groups and those employed in certain occupations, whilst the indirect impacts of Covid-19, including the closure of schools and business and the move to home working, fall HP disproportionately on the young and on women. These factors may in turn impact upon sleep health. Research on sleep deprivation MESHD during the pandemic crisis to date has been limited. The present study aimed to explore the levels and social determinants of self-reported sleep loss among the general population during the Covid-19 pandemic in the UK, with a particular focus on ethnic and gender TRANS disparities. Methods: Newly available national representative survey data from Understanding Society COVID19 Study collected during April 2020 were analysed. These data were linked to Wave 9 of Understanding Society conducted in 2018/19, providing information about the respondents prior to the outbreak of the pandemic. Cross-sectional analysis provided prevalence SERO estimates, whilst analysis of the linked longitudinal data provided incidence estimates. The analytical sample included 15,360 respondents aged TRANS 16 and above; among these, 12,206 reported no problem of sleep loss before the epidemic. Results: Prevalence SERO and incidence rates of perceived sleep loss were 24.7% and 20.2% respectively. Women (at the level of 31.8% and 27.0%) and individuals from Black, Asian, and minority ethnic (BAME) communities (at the level of 32.0% and 24.6%) were more vulnerable to sleep deprivation MESHD due to the pandemic. Multivariate regression analysis shows that being female TRANS, the presence of young children TRANS in the household, perceived financial difficulties and being a Covid-19-related key worker were all predictive of sleep loss. Once these covariates were controlled for the bivariate relationship between ethnicity and sleep loss was reversed, reflecting the complex interaction between the coronavirus epidemic and ethnicity. Conclusions: The pandemic has widened the disparity of sleep deprivation MESHD across different groups, with women with young children TRANS, key workers and people of BAME heritage all experiencing difficulty in sleeping, which in turn may negatively affect mental and physical health and well-being.


    Authors: Absar Ahmad; Ishrat Rahman; Maitri Agarwal

    doi:10.1101/2020.05.03.20081380 Date: 2020-05-06 Source: medRxiv

    Purpose: Research on the impact of social distancing on mental health during epidemics is limited, especially in India. The purpose of this study is to scale the association between anxiety HP and socio-demographic factors during Covid19 lockdown among the general Indian population. Design/methodology/approach: A descriptive cross-sectional nationwide study was designed to enrol the general population. The inclusion criteria for this study were Indian citizens aged TRANS 15 years and above. The study was conducted from 29th March to 12th April 2020, using an online google questionnaire. The anxiety HP among respondents was detected and measured using a Generalised Anxiety HP Disorder Scale which consists of 7 questions (in English), i.e. GAD-7. Findings: Respondees were 398, and from these participants, the prevalence SERO of anxiety HP was 25.4 per cent. Based on the bivariate logistic regression analysis, the predictors of anxiety HP were gender TRANS, religion, occupation as business/self- employed, marital status, family size, health status and sleep deprivation MESHD. Conclusion: This study reports the prevalence SERO of anxiety HP among Indian population who were grounded at their homes during lockdown due to coronavirus pandemic in the country. Limitations: (1) The selection of participants through non-random sampling. (2) Because of the cross-sectional character of the study, causal conclusions cannot be drawn. Originality/Value: This paper fulfils an identified need to study the mental health status of the population under situations like lockdown, thereby helping fill a persistent gap in Indian research on this issue. Keywords: Anxiety HP, GAD-7, Lockdown, Coronavirus, Isolation, India

    Can Melatonin Reduce the Severity of COVID-19 Pandemic?

    Authors: Alex Shneider; Aleksandr Kudriavtsev; Anna Vakhrusheva

    id:10.20944/preprints202004.0122.v2 Date: 2020-04-09 Source:

    The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly TRANS and people with diseases of chronic MESHD inflammation MESHD. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children TRANS don’t suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age TRANS. The programmed cell death MESHD coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation MESHD in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety HP and sleep deprivation MESHD. Melatonin improves sleep habits, reduces anxiety HP and stimulates immunity. Fibrosis MESHD may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis MESHD. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease MESHD symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection MESHD on patients’ health after the active phase of the infection MESHD is over.

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MeSH Disease
Human Phenotype

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