Corpus overview


MeSH Disease

Human Phenotype


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    A Cross-Sectional Study of Olfactory and Taste Disorders MESHD in COVID-19 Patients in China

    Authors: Jianhui Li; Yi Sun; Meirong Li; Hu Yuan; Changliang Yang; Chengcheng Huang; Fengjie Zhou; Ruiyao Chen; Leibo Zhang; Ning Yu; Qiong Liu; Jingjing He; Xuejun Zhou; Xiaobing Fu; Shiming Yang

    doi:10.21203/ Date: 2020-07-20 Source: ResearchSquare

    Objective To determine the prevalance and features of olfactory and taste disorders MESHD in coronavirus disease MESHD of 2019(CoVID-19)patients in China. Methods A cross-sectional study was performed from 3 April to 15 April 2020 in Wuhan. A total of 187 patients with confirmed severe acute respiratory syndrome MESHD coronavirus type 2 (SARS-CoV-2) infection MESHD completed face-to-face interviews or telephone follow-up. Patients information including epidemiological, clinical, imaging, and serological records and treatment and outcomes data. Patients were further evaluated using questionnaires and visual analogue scale. Statistical analysis was performed with SPSS software (version 22.0).  Results The enrolled 187 patients, 23 (12.3%) reported olfactory disorders, 42 (22.46%) reported taste disorders MESHD. Females TRANS are more prone to olfactory and taste disorders MESHD. Among patients that can clearly describe the fluctuation of olfactory and taste disfunctions, 4 (20.0%) and 7(18.92%) cases occurred before other symptoms appeared, the average number of days in advance was 3.5 and 3.57, respectively. The majority of patients can return to normal or basic normal, but in 4(17.39%) and 9(21.43%) cases olfactory and taste can not fully recoveried during the research period. Conclusions  Prevalence of olfactory and taste disorders MESHD substantially lower in China cohorts compared to abroad COVID-19 cohorts. The prevalence SERO of olfactory and taste disorders MESHD in COVID-19 patients was higher in females TRANS than in males TRANS. In some patients, olfactory and taste disorders MESHD precede other symptoms and can be used as a symbol for early screening and warning. The restoration of olfactory and taste function was independent of age TRANS; females recover more easily than males TRANS; olfactory or taste disorders MESHD was not easily recovered for patients with clinically classified as severe; when olfactory or taste disorders MESHD itself was serious, it was not easy to recover; olfactory or taste disorders MESHD occured early in the disease MESHD were more likely to be recovered, otherwise they were hard to be recovered. 

    Clinical Characteristics of Non- Pneumonia MESHD Pneumonia HP COVID-19 Adults TRANS in Shanghai, China

    Authors: Haiying Ji; Lijuan Hu; Tao Li; Linjing Gong; Xu Wu; Qinjun Shen; Zhilong Jiang; Lei Zhu

    doi:10.21203/ Date: 2020-06-19 Source: ResearchSquare

    Background: Since December 2019, coronavirus disease MESHD 2019 (COVID-19) rapidly spread throughout the whole world , data have been needed on the clinical characteristics of the affected patients.Objectives: A total of 579 adult TRANS COVID-19 cases were enrolled in Shanghai from Jan 20 to Apr 15, 2020, in which 95 cases (16.41%) showed non- pneumonia MESHD pneumonia HP on CT when confirmed. The characteristics of non- pneumonia MESHD pneumonia HP cases have not been clearly described previously, and this might provide guidance to prevent and treatment of COVID-19.Method: We retrospectively collected the patient clinical dataset including demography, epidemiology, clinical manifestation, laboratory test results, diagnostic classification, treatment and clinical outcomes.Results: The average age TRANS of 95 COVID-19 cases was 31.45 ± 12.89 years old and 95.79% of them were less than 60 years old. They had mild clinical symptoms and/or laboratory abnormalities. 20 of the 95 cases occurred mild pneumonia MESHD pneumonia HP during hospitalization, accompanied with lower lymphocyte counts, in which 60% cases were complicated with underlying condition and 15% cases were over 60 years old. All cases were cured. 16 of the 95 cases were local residents with clear epidemiological history and long incubation time, and mainly discovered as fever MESHD fever HP and respiratory symptoms. Other 79 cases were overseas imported, some had initial symptoms of diarrhea MESHD diarrhea HP, smell or taste disorders MESHD and so on. They were mainly found at port of entry.Conclusions: Non- pneumonia MESHD pneumonia HP COVID-19 predominantly occurred among young adults TRANS with mild clinical symptoms and possible long incubation time. The patients with underlying condition or at older age TRANS more likely developed mild pneumonia MESHD pneumonia HP after diagnosis. Thereby, it is very important to pay attention to these patients and make reasonable diagnostic classification towards better prevention and treatment of COVID-19.

    Sensitivity SERO and specifity of prediction models based on gustatory disorders in diagnosing COVID-19 patients: a case-control study.

    Authors: Kamil Adamczyk; Michal Herman; Janusz Fraczek; Robert Piec; Barbara Szykula-Piec; Artur Zaczynski; Rafal Wojtowicz; Krzysztof Bojanowski; Ewa Rusyan; Zbigniew Krol; Waldemar Wierzba; Edward Franek

    doi:10.1101/2020.05.31.20118380 Date: 2020-06-03 Source: medRxiv

    Abstract Objective: to quantitatively assess disturbances of sweet, sour and salty and bitter tastes in a group of young, asymptomatic TRANS or oligosymptomatic COVID-19 patients; establish a reliable, sensitive and specific test that can diagnose COVID-19 on the basis of taste disorders MESHD and publish the results according to STARD 2015 statement (Standards for Reporting Diagnostic Accuracy). Design: case-control study Setting: isolated rooms in the Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw (which had been transformed into an infectious hospital) and a dormitory in one of Warsaw universities. Participants: 52 SARS-CoV-2 positive (51 men, mean age TRANS 21.7 years) and 36 negative students (34 men, mean age TRANS 20.8 years). Main outcome measures: a gustatory function assessment (sweet, salty, sour and bitter taste), with flavour concentrations established previously in healthy subjects was conducted for all subjects. Each participant received one tasteless reference and nine flavour tablets with sucrose concentrations of 40, 80 and 106.4 mg/ml; NaCl at 13.5, 17 and 27 mg/ml; ascorbic acid at 6.25 and 12.5 mg/ml and grapefruit extract at 40 mg/ml. Results: the only taste that was impaired significantly more frequently in COVID-19 patients was the sweet taste at the lowest flavour concentration (40 mg/ml, p = 0.002). Different screening and diagnostic models were constructed using the examined variables. The highest accuracy screening test consisted of the positive result of a three-question questionnaire (self-reported loss of taste, self-reported loss of smell, or fever MESHD fever HP within the last month (positive if at least one present) and/or ageusia MESHD of sweet taste at a sucrose concentration of 40 mg/ml. The sensitivity SERO of the model was 94% with a specificity of 55%. The highest accuracy diagnostic test consisted of ageusia MESHD of sweet taste at a sucrose concentration of 106.4 mg/ml or/and ageusia MESHD of salty taste at an NaCl concentration of 13.5 or 17 mg/ml. The specificity of the test was found to be 100%, and the sensitivity SERO was 34%. Conclusion: as the most effective way of controlling the present pandemic involves testing the wider population for symptomatic, oligosymptomatic and asymptomatic TRANS carriers TRANS of SARS-CoV-2 and isolating or hospitalising infected subjects, in the present study, an inexpensive, simple, fast and sensitive (94%) screening test that can be used for such a purpose is proposed. In addition, a specific (100%) diagnostic test that could be used to refer patients to quarantine in the case of limited availability of genetic or serological tests SERO is proposed.

    Ageusia MESHD and Anosmia HP, a Common Aign of COVID-19? A Case Series from Four Countries

    Authors: Jair Vargas-Gandica; Daniel Winter; Rainer Schnippe; Andrea G. Rodriguez-Morales; Johana Mondragon; Juan Pablo Escalera-Antezana; María del Pilar Trelles-Thorne; D. Katterine Bonilla-Aldana; Alfonso J. Rodriguez-Morales; Alberto Paniz-Mondolfi

    id:10.20944/preprints202005.0327.v1 Date: 2020-05-20 Source:

    Over the course of the pandemic due to the severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2), multiple new clinical manifestations, as the consequence of the tropism of the virus, have been recognized. That includes now the neurological manifestations and conditions, such as headache MESHD headache HP, encephalitis MESHD encephalitis HP, as well as olfactory and taste disorders MESHD. We present a series of ten cases of RT-PCR confirmed SARS-CoV-2 infected patients diagnosed with viral-associated olfactory and taste loss from four different countries.

    Self-reported loss of smell and taste in SARS-CoV-2 patients: primary care data to guide future early detection strategies 

    Authors: Benoit Tudrej; Paul Sebo; Julie Lourdaux; Clara Cuzin; Martin Floquet; Dagmar M Haller; Hubert Maisonneuve

    doi:10.21203/ Date: 2020-05-13 Source: ResearchSquare

    The early identification of new cases of SARS-CoV-2 infection MESHD in primary care is of outmost importance in the current pandemia. We conducted a preliminary study involving 816 primary care patients undergoing RT-PCR testing for a suspicion of COVID-19. We examined the association between smell or taste disorders MESHD and a positive SARS-CoV-2 test, and computed the performance SERO of these symptoms in predicting a positive test. Smell or taste disorders MESHD were significantly associated with positive RT-PCR with an adjusted OR=6.3 (95%CI 5.2-7.5). Once confinement measures are lifted, our data could further inform triage and early identification of new clusters of cases through primary TRANS care.

    COVID-19 may present with an itchy erythematous papular rash: a case report

    Authors: Alice Serafini; Peter K. Kurotschka; Mariabeatrice Bertolani; Silvia Riccomi

    doi:10.21203/ Date: 2020-05-06 Source: ResearchSquare

    Background: the most commonly reported clinical manifestations of Coronavirus Disease MESHD (COVID- 19) are: fever MESHD fever HP, fatigue MESHD fatigue HP, dry cough MESHD cough HP, anorexia MESHD anorexia HP, myalgias MESHD myalgias HP, dyspnoea and sputum production. Other, rarer, manifestations include headache MESHD headache HP, sore throat, rhinorrhoea, nausea MESHD nausea HP, diarrhoea and olfactory or taste disorders MESHD. Two recent small-scale studies suggest the possibility of a skin rash HP being a clinical presentation of the disease MESHD. The purpose of our case report is to bring attention to an atypical presentation of the disease (skin MESHD skin rash HP) and reflect on the importance of the correct identification of COVID-19 suspicious symptoms as part of the crucial activity of case-finding in primary care.Case presentation: the patient is an Italian 32 years old female TRANS nurse who has had several close contacts TRANS to COVID-19 cases during her working shifts. On the 13 th March 2020 she developed an itchy erythematous papular rash sparing only her sparing only her face, scalp and abdomen. One week later she developed fever MESHD fever HP and diarrhoea. During the first week of remote assessment carried out by her General Practitioner (GP), she gradually developed a dry cough MESHD cough HP, intermittent fever MESHD fever HP and diarrhoea. At the time of article submission (31 days after the symptoms onset TRANS), she has not completely recovered and is still suffering of a dry cough MESHD cough HP, headache MESHD headache HP, fatigue MESHD fatigue HP and, occasionally, diarrhoea.Conclusions: this study suggest that skin manifestations MESHD could be an early presentation of COVID-19 and, during outbreaks, they should be taken into proper account by primary care providers as possibly caused by Sars-Cov-2. Early identification of COVID-19 patients is a crucial part of the strategy of case detection and case isolation, which has shown to be crucial in the reduction of incidence and COVID-19-related mortality. Further research is needed to establish frequency, symptoms, signs MESHD, pathogenesis and role in case detection of skin manifestations MESHD in COVID-19 patients.

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MeSH Disease
Human Phenotype

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