Corpus overview


MeSH Disease

Diphtheria (4)

Tetanus (4)

Death (3)

Infections (3)

Measles (3)

Human Phenotype

Meningitis (2)

Hepatitis (1)

Fever (1)


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    Possible Cross-Reactivity Between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease MESHD and Death MESHD

    Authors: Robert Root-Bernstein

    id:10.20944/preprints202007.0141.v2 Date: 2020-08-04 Source:

    Various studies indicate that vaccination, especially with pneumococcal vaccines, protects against symptomatic cases of SARS-CoV-2 infection MESHD and death MESHD. This paper explores the possibility that pneumococcal vaccines in particular, but perhaps other vaccines as well, contain antigens that might be cross-reactive with SARS-CoV-2 antigens. Comparison of the glycosylation structures of SARS-CoV-2 with the polysaccharide structures of pneumococcal vaccines yielded no obvious similarities. However, while pneumococcal vaccines are primarily composed of capsular polysaccharides, some are conjugated to CRM197, a modified diphtheria MESHD toxin, and all contain about three percent protein contaminants, including the pneumococcal surface proteins PsaA, PspA and probably PspC. All of these proteins have very high degrees of similarity, using very stringent criteria, with several SARS-CoV-2 proteins including the spike protein, membrane protein and replicase 1a. CRM197 is also present in Hib and meningitis MESHD meningitis HP vaccines. Equivalent similarities were found at statistically significantly lower rates, or were completely absent, among the proteins in diphtheria MESHD, tetanus MESHD, pertussis, measles MESHD, mumps MESHD, rubella MESHD, and poliovirus vaccines. Notably, PspA and PspC are highly antigenic and new pneumococcal vaccines based on them are currently in human clinical trials so that their effectiveness against SARS-CoV-2 disease MESHD is easily testable.

    Do childhood measles MESHD and DTaP vaccination decrease the mortality rate caused by SARS CoV-2 in OECD countries?: An Epidemiologic Study

    Authors: Ramazan Guven; Muhammed Ikbal Sasmaz; Gokhan Eyupoglu; Seda Yilmaz Semerci

    doi:10.21203/ Date: 2020-07-23 Source: ResearchSquare

    Background The mortality rates caused by SARS CoV-2 differ between countries and this difference might be explained by several reasons. Childhood vaccination rate is thought to be one of them. Therefore, present study aimed to examine the possible relationship between DTaP ( diphtheria MESHD, tetanus MESHD, acellular pertussis vaccine) and measles MESHD vaccination rates of Organization for Economic Co-operation and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.Methods A total of 32 OECD countries, of northern hemisphere, have been included in this study. Statistical analysis performed according to the CFR data of these countries based on SARS CoV-2. The CFR data calculated according to the total mortality count of a specific country for the 3-month period down from the date when first SARS CoV-2 case was observed. Results Based on the correlation levels of vaccination rates of OECD countries with a period of 3-month CFR, a strong negative correlation of significance between CFR and measles MESHD (r=-0.479, p=0.006) were pointed, while a negative but not significant correlation were seen between CFR and DTaP vaccination rates (r=-264.0, p=0.145). Conclusion Depending on the results of the study, lower CFR based on COVID-19, is suggested to be related to the successful vaccination rates of those OECD countries. Therefore, further effort is required to improve rates of childhood vaccination not only for specified diseases MESHD, but either possible protection against COVID-19 worldwide. Trial Registration: This study is registered to with trial number: NCT04468802.

    Worldwide inverse correlation between Bacille Calmette-Guérin immunization and COVID-19 morbidity and mortality

    Authors: Willis X. Li

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    The COVID-19 pandemic has spread to all countries in the world after more than six months since it was first reported in late 2019, and different countries have been impacted differently.  Correlation analysis between COVID-19 death MESHD numbers and different demographic and socioeconomic factors for all world countries (n=210) as of June 1, 2020, reveals that COVID-19 deaths MESHD per million population in a country significantly correlates with the country’s median age TRANS (r=0.48, p=4.8e-4) and per capita gross domestic product (GDP) (r=0.55, p=4.14e-5), and inversely correlates with the country’s Bacille Calmette-Guérin (BCG) vaccination rate (r=–0.63, p=9.9e-7). COVID-19 death MESHD is found not significantly associated, however, with a country’s policy stringency index, population density, extreme poverty rate, hospital beds availability per thousand people, and diphtheria MESHD- tetanus MESHD-pertussis (DTP3) immunization. Old age TRANS is likely a confounding factor for the correlation between COVID-19 and per capita GDP (r=0.66, p=2.3e-7). To control for possible confounding effects of age TRANS, countries with similar median age were grouped TRANS and analyzed. The inverse correlation between BCG vaccination rates and COVID-19 case (r=–0.338, p=0.0082) and death MESHD (r=–0.411, p=0.0011) remained significant among the top 61 countries with highest median age TRANS.  The current study suggests that BCG might be protective against SARS-CoV-2 infection MESHD.

    Benefit-risk analysis of health benefits of routine childhood immunisation against the excess risk of SARS-CoV-2 infections MESHD during the Covid-19 pandemic in Africa

    Authors: Kaja Abbas; Simon R Procter; Kevin van Zandvoort; Andrew Clark; Sebastian Funk; - LSHTM CMMID Covid-19 Working Group; Tewodaj Mengistu; Dan Hogan; Emily Dansereau; Mark Jit; Stefan Flasche

    doi:10.1101/2020.05.19.20106278 Date: 2020-05-26 Source: medRxiv

    Background: National immunisation programmes globally are at risk of suspension due to the severe health system constraints and physical distancing measures in place to mitigate the ongoing COVID-19 pandemic. Our aim is to compare the health benefits of sustaining routine childhood immunisation in Africa against the risk of acquiring SARS-CoV-2 infections MESHD through visiting routine vaccination service delivery points. Methods: We used two scenarios to approximate the child TRANS deaths MESHD that may be caused by immunisation coverage reductions during COVID-19 outbreaks. First, we used previously reported country-specific child TRANS mortality impact estimates of childhood immunisation for diphtheria MESHD, tetanus MESHD, pertussis, hepatitis B MESHD hepatitis HP, Haemophilus influenzae type b, pneumococcal, rotavirus, measles MESHD, meningitis MESHD meningitis HP A, rubella MESHD, and yellow fever MESHD fever HP (DTP3, HepB3, Hib3, PCV3, RotaC, MCV1, MCV2, MenA, RCV, YFV) to approximate the future deaths MESHD averted before completing five years of age TRANS by routine childhood vaccination during a 6-month COVID-19 risk period without catch-up campaigns. Second, we analysed an alternative scenario that approximates the health benefits of sustaining routine childhood immunisation to only the child TRANS deaths MESHD averted from measles MESHD outbreaks during the COVID-19 risk period. The excess number of infections MESHD due to additional SARS-CoV-2 exposure during immunisation visits assumes that contact reducing interventions flatten the outbreak curve during the COVID-19 risk period, that 60% of the population will have been infected by the end of that period, that children TRANS can be infected by either vaccinators or during transport and that upon child TRANS infection MESHD the whole household would be infected. Country specific household age TRANS structure estimates and age TRANS dependent infection MESHD fatality rates are then applied to calculate the number of deaths MESHD attributable to the vaccination clinic visits. We present benefit-risk ratios for routine childhood immunisation alongside 95% uncertainty range estimates from probabilistic sensitivity SERO analysis. Findings: For every one excess COVID-19 death MESHD attributable to SARS-CoV-2 infections MESHD acquired during routine vaccination clinic visits, there could be 84 (14-267) deaths MESHD in children TRANS prevented by sustaining routine childhood immunisation in Africa. The benefit-risk ratio for the vaccinated children TRANS, siblings, parents TRANS or adult TRANS care-givers, and older adults TRANS in the households of vaccinated children TRANS are 85,000 (4,900 - 546,000), 75,000 (4,400 - 483,000), 769 (148 - 2,700), and 96 (14 - 307) respectively. In the alternative scenario that approximates the health benefits to only the child TRANS deaths MESHD averted from measles MESHD outbreaks, the benefit-risk ratio to the households of vaccinated children TRANS is 3 (0 - 10) under these highly conservative assumptions and if the risk to only the vaccinated children TRANS is considered, the benefit-risk ratio is 3,000 (182 - 21,000). Interpretation: Our analysis suggests that the health benefits of deaths MESHD prevented by sustaining routine childhood immunisation in Africa far outweighs the excess risk of COVID-19 deaths MESHD associated with vaccination clinic visits, especially for the vaccinated children TRANS. However, there are other factors that must be considered for strategic decision making to sustain routine childhood immunisation in African countries during the COVID-19 pandemic. These include logistical constraints of vaccine supply chain problems caused by the COVID-19 pandemic, reallocation of immunisation providers to other prioritised health services, healthcare staff shortages caused by SARS-CoV-2 infections MESHD among the staff, decreased demand for vaccination arising from community reluctance to visit vaccination clinics for fear of contracting SARS-CoV-2 infections MESHD, and infection MESHD infection risk TRANS infection risk TRANS risk to healthcare staff providing immunisation services as well as to their households and onward SARS-CoV-2 transmission TRANS into the wider community.

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MeSH Disease
Human Phenotype

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