Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

    displaying 1 - 3 records in total 3
    records per page

    Olfactory dysfunction quantified by olfactometry in patients with SARS-Cov-2 infection MESHD

    Authors: Maria Teresa Cervilla; Irene Gutierrez; Maria Romero; Javier Garcia-Gomez

    doi:10.21203/ Date: 2020-06-15 Source: ResearchSquare

    Objective: To quantify olfactory dysfunction by olfactometry in patients with laboratory confirmed SARS-Cov-2 infection MESHD.Methods: Patients from a particular Spanish health area with SARS-Cov-2 infection MESHD were recruited to study the loss of smell. Olfactometry was performed using the Sniffin Sticks test. The following clinical symtoms were studied: ENT symptoms related to infection MESHD, duration of sensorineural loss, subjective and objective score of loss of smell, and its temporal relationship with other systemic symptoms.Results: A total of 51 patients with SARS-Cov-2 infection MESHD completed the study. A total of 86.3% reported subjective loss of smell capacity. Objective loss of olfactory ability was quantified by olfactometry in 22% of patients. Statistical significance was demonstrated between the group of patients with anosmia HP/ hyposmia HP and the Sniffin Sticks test (p-value: 0.013). The most frequent ENT symptoms in patients with quantified olfactory loss consisted of nasal obstruction MESHD nasal obstruction HP, absence of rhinorrhea HP, sore throat, and ear pain HP pain MESHD. The subjective olfactory recovery rate prior to performing olfactometry was 64.3% of the sample. A total of 77% of patients in whom olfactory loss was quantified by olfactometry reported a subjective duration of more than 15 days.Conclusion: Olfactory dysfunction is an objective clinical finding in patients with SARS- Cov-2 infection MESHD. Its persistence has been demonstrated beyond the first month after infection MESHD. Their quantitative study should be continued to determine the recovery rate and its possible long-term sequelae, as well as treatments to improve the quality of life of these patients.

    Objective Olfactory Evaluation of Self-reported Olfactory Dysfunction in a Case Series of 86 COVID-19 Patients

    Authors: Pierre Cabaraux; Jerome R. Lechien; sven saussez; Carlos M Chiesa-Estomba; Mohamad Khalife; Stephane Hans; Delphine Martiny; Fabrice Journe; Christian Calvo Henriquez; Leigh Sowerby

    doi:10.1101/2020.05.03.20088526 Date: 2020-05-08 Source: medRxiv

    Objective: To investigate olfactory dysfunction in patients with mild COVID-19 through patient-reported outcome questionnaires and objective psychophysical testing. Methods: Adult TRANS patients with COVID-19 and self-reported sudden-onset olfactory dysfunction were recruited through a public call for participation from the University of Mons. Demographic data, pathologic conditions, general and otolaryngological symptoms were collected, and general nasal complaints were evaluated with the sino-nasal outcome-22 (SNOT-22). Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey (NHNES) and the short version of the Questionnaire of Olfactory Disorders-Negative Statements. Objective olfactory status was evaluated using an objective psychophysical test (Identification Sniffin Stick test). Results : 86 patients completed the study. The mean age TRANS was 42 + or - 12 years. The most common symptoms were fatigue MESHD fatigue HP (75%), headache MESHD headache HP (63%), nasal obstruction MESHD nasal obstruction HP (58%), dysgeusia MESHD (51%), postnasal drip (49%), cough MESHD cough HP (49%) and myalgia MESHD myalgia HP (46%). On NHNES, total loss of taste and smell were reported by 51% and 74% of patients, respectively. 65% of patients reported a total loss of smell, while the remainder reported a partial loss. Objective olfactory testing found 41 anosmic (48%), 12 hyposmics (14%), and 33 normosmics (38%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction MESHD nasal obstruction HP or postnasal drip, these complaints were absent in 69% of anosmic patients. Conclusion : A significant proportion of patients reporting olfactory dysfunction related to COVID-19 infection MESHD do not have olfactory dysfunction on objective testing. Furthermore, a majority of those with measured olfactory dysfunction did not have corresponding nasal obstruction MESHD nasal obstruction HP.

    More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

    Authors: Valentina Parma; Kathrin Ohla; Maria G. Veldhuizen; Masha Y. Niv; Christine E. Kelly; Alyssa J. Bakke; Keiland W. Cooper; Cédric Bouysset; Nicola Pirastu; Michele Dibattista; Rishemjit Kaur; Marco Tullio Liuzza; Marta Y. Pepino; Veronika Schöpf; Veronica Pereda-Loth; Shannon B Olsson; Richard C Gerkin; Paloma Rohlfs Domínguez; Javier Albayay; Michael C. Farruggia; Surabhi Bhutani; Alexander W Fjaeldstad; Ritesh Kumar; Anna Menini; Moustafa Bensafi; Mari Sandell; Iordanis Konstantinidis; Antonella Di Pizio; Federica Genovese; Lina Öztürk; Thierry Thomas-Danguin; Johannes Frasnelli; Sanne Boesveldt; Özlem Saatci; Luis R. Saraiva; Cailu Lin; Jérôme Golebiowski; Liang-Dar Hwang; Mehmet Hakan Ozdener; Maria Dolors Guàrdia; Christophe Laudamiel; Marina Ritchie; Jan Havlícek; Denis Pierron; Eugeni Roura; Marta Navarro; Alissa A. Nolden; Juyun Lim; KL Whitcroft; Lauren R. Colquitt; Camille Ferdenzi; Evelyn V. Brindha; Aytug Altundag; Alberto Macchi; Alexia Nunez-Parra; Zara M. Patel; Sébastien Fiorucci; Carl M. Philpott; Barry C. Smith; Johan N Lundström; Carla Mucignat; Jane K. Parker; Mirjam van den Brink; Michael Schmuker; Florian Ph.S Fischmeister; Thomas Heinbockel; Vonnie D.C. Shields; Farhoud Faraji; Enrique Enrique Santamaría; William E.A. Fredborg; Gabriella Morini; Jonas K. Olofsson; Maryam Jalessi; Noam Karni; Anna D'Errico; Rafieh Alizadeh; Robert Pellegrino; Pablo Meyer; Caroline Huart; Ben Chen; Graciela M. Soler; Mohammed K. Alwashahi; Olagunju Abdulrahman; Antje Welge-Lüssen; Pamela Dalton; Jessica Freiherr; Carol H. Yan; Jasper H. B. de Groot; Vera V. Voznessenskaya; Hadar Klein; Jingguo Chen; Masako Okamoto; Elizabeth A. Sell; Preet Bano Singh; Julie Walsh-Messinger; Nicholas S. Archer; Sachiko Koyama; Vincent Deary; S. Craig Roberts; Hüseyin Yanik; Samet Albayrak; Lenka Martinec Novákov; Ilja Croijmans; Patricia Portillo Mazal; Shima T. Moein; Eitan Margulis; Coralie Mignot; Sajidxa Mariño; Dejan Georgiev; Pavan K. Kaushik; Bettina Malnic; Hong Wang; Shima Seyed-Allaei; Nur Yoluk; Sara Razzaghi; Jeb M. Justice; Diego Restrepo; Julien W Hsieh; Danielle R. Reed; Thomas Hummel; Steven D Munger; John E Hayes

    doi:10.1101/2020.05.04.20090902 Date: 2020-05-08 Source: medRxiv

    Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia HP. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted to data from single countries. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages TRANS 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease MESHD. Difference scores (maximum possible change+/-100) revealed a mean reduction of smell (-79.7+/- 28.7, mean+/- SD), taste (-69.0+/- 32.6), and chemesthetic (-37.3+/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction MESHD nasal obstruction HP did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction MESHD nasal obstruction HP suggest that SARS-CoV-2 infection MESHD may disrupt sensory-neural mechanisms.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.